MEIS1 and HOXD11

Number of citations of the paper that reports this interaction (PMID 9343407)
63

Data Source:
HPRD (in vitro)

		MEIS1	HOXD11
Gene Name		Meis homeobox 1	homeobox D11
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity	Sequence-specific DNA Binding
	Biological Process	Angiogenesis Lens Morphogenesis In Camera-type Eye Transcription From RNA Polymerase II Promoter Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Definitive Hemopoiesis	Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Transcription, DNA-templated Regulation Of Transcription, DNA-templated Single Fertilization Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Positive Regulation Of Cell Development Positive Regulation Of Chondrocyte Differentiation Embryonic Forelimb Morphogenesis Embryonic Digit Morphogenesis Developmental Growth Embryonic Skeletal Joint Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis
Pathways
Drugs
Diseases
GWAS		PR interval ( 20062060 23139255) Restless legs syndrome ( 17637780 21779176)
Protein-Protein Interactions		27 interactors: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B	2 interactors: HMGB1 MEIS1
Entrez ID		4211	3237
HPRD ID		03442	00869
Ensembl ID		ENSG00000143995
Uniprot IDs		F5GYS8 F8W8U3 O00470	P31277
PDB IDs
Enriched GO Terms of Interacting Partners?		Anterior/posterior Pattern Specification Pattern Specification Process Embryonic Morphogenesis Transcription, DNA-templated Skeletal System Development Embryonic Skeletal System Development RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Multicellular Organismal Development System Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Embryonic Skeletal System Morphogenesis RNA Metabolic Process Limb Development Embryo Development Gene Expression Organ Development Developmental Process Organ Morphogenesis Embryonic Limb Morphogenesis Cellular Macromolecule Biosynthetic Process Anatomical Structure Development Macromolecule Biosynthetic Process Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Proximal/distal Pattern Formation Positive Regulation Of Transcription, DNA-templated Skeletal System Morphogenesis Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Embryonic Organ Morphogenesis Regulation Of Metabolic Process Embryonic Organ Development Cellular Nitrogen Compound Metabolic Process Chordate Embryonic Development Nitrogen Compound Metabolic Process Embryo Development Ending In Birth Or Egg Hatching Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Embryonic Forelimb Morphogenesis	Negative Regulation Of Apoptotic Cell Clearance Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Base-excision Repair, DNA Ligation Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly DNA Ligation Involved In DNA Repair Regulation Of Apoptotic Cell Clearance Immune System Development Negative Regulation Of Phagocytosis DNA Ligation Dendritic Cell Chemotaxis Megakaryocyte Development Apoptotic DNA Fragmentation Regulation Of DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Megakaryocyte Differentiation Definitive Hemopoiesis Dendritic Cell Migration Myeloid Dendritic Cell Activation Positive Chemotaxis V(D)J Recombination Lens Morphogenesis In Camera-type Eye Apoptotic Nuclear Changes Inflammatory Response To Antigenic Stimulus DNA Topological Change Positive Regulation Of DNA Binding Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Endocytosis Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Generation Of Neurons Positive Regulation Of Cellular Biosynthetic Process Neurogenesis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Base-excision Repair Regulation Of Phagocytosis Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Execution Phase Of Apoptosis Negative Regulation Of Myeloid Cell Differentiation Regulation Of DNA Binding DNA Catabolic Process, Endonucleolytic Lens Development In Camera-type Eye Immune System Process Leukocyte Chemotaxis Nervous System Development Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Binding Positive Regulation Of Cysteine-type Endopeptidase Activity
Tagcloud ?		acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations	affymetrix baiap2l1 ccl8 clec12a dqa2 esr fls gpr64 hapln1 haq homeobox lim mab21l2 methotrexate oa osap osteoarthritis peroxisome pou3f3 prednisone rf rgmb rheumatoid sarcoglycan sedimentation siat7e tripartite
Tagcloud (Difference) ?		acetyltransferase aggressive characteristically emu fusing haploinsufficient hence hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations	affymetrix baiap2l1 ccl8 clec12a dqa2 esr fls gpr64 hapln1 haq lim mab21l2 methotrexate oa osap osteoarthritis peroxisome pou3f3 prednisone rf rgmb rheumatoid sarcoglycan sedimentation siat7e tripartite
Tagcloud (Intersection) ?		homeobox