TLX3 and TLE2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		TLX3	TLE2
Description		T cell leukemia homeobox 3	TLE family member 2, transcriptional corepressor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Extracellular Space Nucleus Nucleoplasm Transcription Regulator Complex Focal Adhesion Nuclear Body
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Neuron Migration Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Respiratory Gaseous Exchange By Respiratory System Neuron Differentiation Negative Regulation Of Neuron Differentiation Animal Organ Development Neuron Fate Specification GABAergic Neuron Differentiation	Regulation Of DNA-templated Transcription Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Body size at age 10 ( 32376654)
Interacting Genes		108 interacting genes: ACTMAP ACY1 AKAP9 ANKRD10 ANKRD33 AOC1 APBB1IP ARMC5 ASB12 ATP6V0D1 B9D2 BPIFA1 C2orf42 CEACAM6 CFAP68 CIMIP2B CRX CSNK2B CTNNA3 DENND4A EFEMP2 ERAS FAM168B FCSK FNTB FOSB FOXH1 GGTLC2 GOLGA6L9 GTF2A1L H2BC11 HNF1B HNRNPUL1 HOPX HSPB2 HSPB2-C11orf52 HYI IGFL2 ING4 INTS11 IRF9 ITIH6 KCNJ5-AS1 KRT34 KRTAP11-1 KRTAP13-3 KRTAP19-1 KRTAP19-7 KRTAP3-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LMO2 MAGED1 MEIS1 METTL27 MORN5 MSX2 NDUFAB1 NFIC NFIX NHLRC4 NICN1 OIP5 PLA2G10 PLAAT1 POU2AF1 POU6F2 PPP1CC PQBP1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB11 REL ROR2 RSKR SERPINE1 SLC15A2 SMU1 SNTA1 SP1 SPATA46 SPMIP9 SPRYD7 STH SYNGAP1 TBX22 TCIRG1 TEKT5 THTPA TLE2 TMEM42 TOX2 TP53BP1 TRIM42 UFSP1 WDR83 YPEL3 ZBTB32 ZNF34 ZNF41 ZNF44	16 interacting genes: BARHL1 EMX2 FOXA3 H3-3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX
Entrez ID		30012	7089
HPRD ID		06868	03025
Ensembl ID		ENSG00000164438	ENSG00000065717
Uniprot IDs		O43711	K7EMK7 Q04725
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Protein Binding Chromatin	Sequence-specific Double-stranded DNA Binding Chromatin DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Developmental Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cell Differentiation Animal Organ Development Cell Population Proliferation Nucleus Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Cellular Developmental Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding BMP Signaling Pathway Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Odontogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Positive Regulation Of Mesenchymal Cell Apoptotic Process Positive Regulation Of Biosynthetic Process Face Morphogenesis DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regionalization Midbrain Development Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Animal Organ Morphogenesis Embryonic Nail Plate Morphogenesis Positive Regulation Of BMP Signaling Pathway Tube Morphogenesis Negative Regulation Of Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?