MEIS1 and HOXD13

Number of citations of the paper that reports this interaction (PMID 15617687)
15

Data Source:
HPRD (two hybrid, in vivo)

		MEIS1	HOXD13
Gene Name		Meis homeobox 1	homeobox D13
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding
	Biological Process	Angiogenesis Lens Morphogenesis In Camera-type Eye Transcription From RNA Polymerase II Promoter Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Definitive Hemopoiesis	Skeletal System Development Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Anterior/posterior Pattern Specification Male Genitalia Development Regulation Of Cell Proliferation Embryonic Digit Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Hindgut Morphogenesis Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Morphogenesis Of An Epithelial Fold Branch Elongation Of An Epithelium Regulation Of Branching Involved In Prostate Gland Morphogenesis
Pathways
Drugs
Diseases
GWAS		PR interval ( 20062060 23139255) Restless legs syndrome ( 17637780 21779176)
Protein-Protein Interactions		27 interactors: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B	5 interactors: CREBBP MEIS1 SMAD1 SMAD2 SMAD5
Entrez ID		4211	3239
HPRD ID		03442	00872
Ensembl ID		ENSG00000143995	ENSG00000128714
Uniprot IDs		F5GYS8 F8W8U3 O00470	P35453
PDB IDs
Enriched GO Terms of Interacting Partners?		Anterior/posterior Pattern Specification Pattern Specification Process Embryonic Morphogenesis Transcription, DNA-templated Skeletal System Development Embryonic Skeletal System Development RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Multicellular Organismal Development System Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Embryonic Skeletal System Morphogenesis RNA Metabolic Process Limb Development Embryo Development Gene Expression Organ Development Developmental Process Organ Morphogenesis Embryonic Limb Morphogenesis Cellular Macromolecule Biosynthetic Process Anatomical Structure Development Macromolecule Biosynthetic Process Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Proximal/distal Pattern Formation Positive Regulation Of Transcription, DNA-templated Skeletal System Morphogenesis Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Embryonic Organ Morphogenesis Regulation Of Metabolic Process Embryonic Organ Development Cellular Nitrogen Compound Metabolic Process Chordate Embryonic Development Nitrogen Compound Metabolic Process Embryo Development Ending In Birth Or Egg Hatching Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Embryonic Forelimb Morphogenesis	Positive Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Fate Commitment Primary MiRNA Processing Embryonic Pattern Specification Positive Regulation Of Transcription, DNA-templated Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Mesonephros Development Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Skeletal System Development Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Kidney Epithelium Development Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Response To BMP Stimulus Production Of MiRNAs Involved In Gene Silencing By MiRNA Bone Development Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway RNA Biosynthetic Process Anatomical Structure Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Positive Regulation Of Cellular Metabolic Process Cell Fate Commitment Kidney Development Gene Silencing By MiRNA Cellular Response To DsRNA Renal System Development Embryo Development Posttranscriptional Gene Silencing Urogenital System Development Cellular Response To Organic Cyclic Compound RNA Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Gene Expression Gene Silencing By RNA Pattern Specification Process Positive Regulation Of Osteoblast Differentiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To DsRNA BMP Signaling Pathway
Tagcloud ?		acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations	accepted accumulating blasts bm complimentary cytopenias drives dysplastic faithfully glycosylphosphatidylinositol h2ax hit hspc hspcs instability likelihood nhd13 nonlethal nup98 pb pig progresses recapitulate reticulocytes serial surrogate transgene transgenically underscores
Tagcloud (Difference) ?		acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations	accepted accumulating blasts bm complimentary cytopenias drives dysplastic faithfully glycosylphosphatidylinositol h2ax hit hspc hspcs instability likelihood nhd13 nonlethal nup98 pb pig progresses recapitulate reticulocytes serial surrogate transgene transgenically underscores
Tagcloud (Intersection) ?