MEIS1 and HOXB4

Number of citations of the paper that reports this interaction (PMID 15617687)
15

Data Source:
HPRD (two hybrid)

		MEIS1	HOXB4
Gene Name		Meis homeobox 1	homeobox B4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding
	Biological Process	Angiogenesis Lens Morphogenesis In Camera-type Eye Transcription From RNA Polymerase II Promoter Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Definitive Hemopoiesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Morphogenesis Of An Epithelial Sheet Transcription, DNA-templated Cell Proliferation Anterior/posterior Pattern Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter Somatic Stem Cell Division Spleen Development Bone Marrow Development Embryonic Skeletal System Morphogenesis Definitive Hemopoiesis Hematopoietic Stem Cell Differentiation Positive Regulation Of Stem Cell Differentiation
Pathways
Drugs
Diseases
GWAS		PR interval ( 20062060 23139255) Restless legs syndrome ( 17637780 21779176)
Protein-Protein Interactions		27 interactors: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B	3 interactors: CREBBP EP300 MEIS1
Entrez ID		4211	3214
HPRD ID		03442	07032
Ensembl ID		ENSG00000143995
Uniprot IDs		F5GYS8 F8W8U3 O00470	P17483
PDB IDs
Enriched GO Terms of Interacting Partners?		Anterior/posterior Pattern Specification Pattern Specification Process Embryonic Morphogenesis Transcription, DNA-templated Skeletal System Development Embryonic Skeletal System Development RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Multicellular Organismal Development System Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Embryonic Skeletal System Morphogenesis RNA Metabolic Process Limb Development Embryo Development Gene Expression Organ Development Developmental Process Organ Morphogenesis Embryonic Limb Morphogenesis Cellular Macromolecule Biosynthetic Process Anatomical Structure Development Macromolecule Biosynthetic Process Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Proximal/distal Pattern Formation Positive Regulation Of Transcription, DNA-templated Skeletal System Morphogenesis Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Embryonic Organ Morphogenesis Regulation Of Metabolic Process Embryonic Organ Development Cellular Nitrogen Compound Metabolic Process Chordate Embryonic Development Nitrogen Compound Metabolic Process Embryo Development Ending In Birth Or Egg Hatching Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Embryonic Forelimb Morphogenesis	N-terminal Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia N-terminal Protein Amino Acid Modification Regulation Of Cellular Response To Heat Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Heat Positive Regulation Of Type I Interferon Production Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Type I Interferon Production Cellular Response To Oxygen Levels Response To Heat Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Acetylation Notch Signaling Pathway Histone H2B Acetylation Positive Regulation Of Transcription, DNA-templated Response To Temperature Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Peptidyl-lysine Modification Response To Hypoxia Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Regulation Of Tubulin Deacetylation Germ-line Stem Cell Maintenance Positive Regulation Of Cytokine Production Immune System Process Histone Modification Transcription, DNA-templated RNA Biosynthetic Process Anatomical Structure Morphogenesis Positive Regulation By Host Of Viral Transcription Positive Regulation Of Cellular Metabolic Process Regulation Of Cytokine Production Viral Process Chromatin Modification Megakaryocyte Development RNA Metabolic Process Regulation Of Androgen Receptor Signaling Pathway Chromatin Organization Negative Regulation Of Cell Differentiation
Tagcloud ?		acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations	advances begun biology commitment correlate determination developmental dlk experimental flk gata genetic hematopoietic identify impact implicated loci major mapping mpl numbers others recently regulators scl stem strategies strongly variety
Tagcloud (Difference) ?		acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations	advances begun biology commitment correlate determination developmental dlk experimental flk gata genetic hematopoietic identify impact implicated loci major mapping mpl numbers others recently regulators scl stem strategies strongly variety
Tagcloud (Intersection) ?