MECP2 and PRPF40A

Number of citations of the paper that reports this interaction (PubMedID 9171351)
40

Data Source:
HPRD (in vitro)

		MECP2	PRPF40A
Description		methyl-CpG binding protein 2	pre-mRNA processing factor 40A
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GO Annotations	Cellular Component	Chromatin Heterochromatin Extracellular Space Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Synapse Postsynapse	Nucleus Nucleoplasm U1 SnRNP Membrane Nuclear Matrix Nuclear Speck U2-type Prespliceosome
	Molecular Function	Nucleic Acid Binding DNA Binding Chromatin Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding SiRNA Binding Molecular Adaptor Activity Histone Reader Activity Molecular Condensate Scaffold Activity Promoter-specific Chromatin Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Behavioral Fear Response Response To Hypoxia Startle Response Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Respiratory Gaseous Exchange By Nervous System Process Inositol Metabolic Process Regulation Of Transcription By RNA Polymerase II Glutamine Metabolic Process Biogenic Amine Metabolic Process Notch Signaling Pathway Chemical Synaptic Transmission Synapse Assembly Brain Development Respiratory Gaseous Exchange By Respiratory System Learning Memory Long-term Memory Intracellular Protein Localization Glucocorticoid Metabolic Process Cell Population Proliferation Associative Learning Adult Locomotory Behavior Visual Learning Post-embryonic Development Gene Expression Regulation Of Gene Expression Negative Regulation Of Gene Expression Glial Cell Proliferation Dendrite Development Negative Regulation Of Angiogenesis Proprioception Sensory Perception Of Pain Cerebellum Development Ventricular System Development Neuron Differentiation Neuron Projection Development Heterochromatin Formation Cardiolipin Metabolic Process Multicellular Organismal Response To Stress Social Behavior Epigenetic Regulation Of Gene Expression Neuron Maturation Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Phosphatidylcholine Metabolic Process Regulation Of Synaptic Plasticity Cell Development Catecholamine Secretion Neuromuscular Process Controlling Posture Neuromuscular Process Negative Regulation Of Developmental Process Negative Regulation Of Smooth Muscle Cell Differentiation Response To Other Organism Excitatory Postsynaptic Potential Positive Regulation Of Glial Cell Proliferation Long-term Synaptic Potentiation Genomic Imprinting Positive Regulation Of Microtubule Nucleation Trans-synaptic Signaling By BDNF Regulation Of Multicellular Organismal Development	MRNA Splicing, Via Spliceosome MRNA Processing Cytoskeleton Organization Regulation Of Cell Shape RNA Splicing Cell Migration Regulation Of Cytokinesis MRNA Cis Splicing, Via Spliceosome Cell Division
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases		Non-syndromic X-linked mental retardation Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS) Rett syndrome
GWAS		Non-albumin protein levels ( 29403010) Red blood cell traits ( 23446634) Schizophrenia ( 24043878) Systemic lupus erythematosus ( 19838195 26502338 26663301)	Heel bone mineral density ( 30598549) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Metabolite levels ( 23823483) Pulse pressure ( 30224653) Refractive error ( 32231278)
Interacting Genes		17 interacting genes: DNMT1 DNMT3L GTF2B H3C15 HIPK2 HMGB1 NCOR1 PRPF40A PRPF40B SIN3A SKI SMARCA2 SMARCB1 SOX18 SPI1 TBL1X TBL1XR1	132 interacting genes: ABI1 AKAP8L APBB1IP ARFGEF2 ASXL2 ATAD3A BAG6 BEND7 BRD4 CAP2 CCNL1 CCT2 CCT4 CCT7 CDK12 CDK13 CHD3 CHERP CPSF6 CT45A1 CUL1 CYFIP1 CYFIP2 DAAM1 DDIT4L DHX15 DHX8 DHX9 DIAPH1 DZIP1 DZIP1L ENAH ERG EVL FASLG FMN1 FMNL1 FMNL2 FMNL3 FN1 FNBP4 FRA10AC1 GAPDH HIPK1 HNRNPF HNRNPK HNRNPU HNRNPUL1 HSPB1 HSPG2 HTT IL1RAP KMT2B LARP7 LTBP3 MAP1LC3A MECP2 MMP11 NCKAP1L NKAP NKAPD1 NONO PCBP2 PDCD7 PECAM1 PFKL PIAS1 PIAS3 PIAS4 PICK1 PPIG PRKAR1A PSG5 PTBP1 PTPRF RBM39 RBMX2 RCC2 RLF RNF10 RPL4 RPLP0 SDCBP SDCBP2 SDK1 SERPINB9 SF1 SF3A1 SF3A2 SF3A3 SF3B2 SF3B3 SFPQ SMAD4 SNIP1 SNRNP70 SON SPMIP2 SREK1 SREK1IP1 SRPK2 STIM2 TCEAL9 TMEM132D U2AF1 U2AF2 U2SURP UBE2I UBE2K UBQLN1 UBQLN2 UBQLN4 UBR4 USP7 VASP VCL WAS WASF2 WASL WBP11 WBP4 WIPF1 XRCC6 YBX1 YLPM1 YWHAG ZCCHC10 ZCCHC8 ZFHX3 ZHX1 ZNF341 ZNF451
Entrez ID		4204	55660
HPRD ID		02050	10995
Ensembl ID		ENSG00000169057	ENSG00000196504
Uniprot IDs		A0A140VKC4 D3YJ43 P51608 Q59FJ6	A0A7N4I394 A0A8Q3SIG7 A0A8V8TM61 F5H578 O75400
PDB IDs		1QK9 3C2I 5BT2 6C1Y 6OGJ 6OGK 6YWW 8AJR 8ALQ	1UZC 1YWI 1YWJ 1ZR7 2CQN 2DYF 2KZG 2L5F 2L9V 2LKS 8PXW 8PXX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Transcription Repressor Complex Epigenetic Regulation Of Gene Expression Chromatin Remodeling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Negative Regulation Of Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone Deacetylase Complex Nucleoplasm Regulation Of RNA Metabolic Process Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic DNA Binding Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Germ Cell Nucleus Regulation Of Nucleotide-excision Repair Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA Binding Positive Regulation Of Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Metabolic Process Cellular Developmental Process Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Leukocyte Differentiation	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Nuclear Speck Nucleic Acid Binding Spliceosomal Complex Nucleoplasm Nucleus Spliceosomal Complex Assembly RNA Metabolic Process U2 SnRNP Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly Actin Binding U2-type Precatalytic Spliceosome Profilin Binding SCAR Complex Cellular Component Assembly Actin Polymerization Or Depolymerization Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex MRNA 3'-splice Site Recognition Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein-RNA Complex Assembly Actin Filament-based Process Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Metabolic Process Protein Binding Alternative MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of Macromolecule Metabolic Process PML Body SUMO Ligase Activity Cytosol U2-type Spliceosomal Complex Positive Regulation Of Macromolecule Metabolic Process Actin Cytoskeleton Organization Focal Adhesion Regulation Of Metabolic Process U2-type Prespliceosome CRD-mediated MRNA Stability Complex
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