MECP2 and DNMT1

Number of citations of the paper that reports this interaction (PMID 12473678)
64

Data Source:
BioGRID (pull down)

		MECP2	DNMT1
Gene Name		methyl CpG binding protein 2	DNA (cytosine-5-)-methyltransferase 1
Image
Gene Ontology Annotations	Cellular Component	Heterochromatin Extracellular Space Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Replication Fork Pericentric Heterochromatin
	Molecular Function	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity MRNA Binding Protein Binding Transcription Factor Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Protein Domain Specific Binding SiRNA Binding Poly(A) RNA Binding Protein N-terminus Binding	DNA Binding Chromatin Binding RNA Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Methyl-CpG Binding DNA-methyltransferase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Behavioral Fear Response Response To Hypoxia Startle Response Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Respiratory Gaseous Exchange By Neurological System Process Inositol Metabolic Process Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Transcription, DNA-templated Glutamine Metabolic Process Synapse Assembly Respiratory Gaseous Exchange Long-term Memory Protein Localization Glucocorticoid Metabolic Process Positive Regulation Of Cell Proliferation Adult Locomotory Behavior Visual Learning Pathogenesis Post-embryonic Development Dendrite Development Histone Methylation Histone Acetylation Proprioception Sensory Perception Of Pain Cerebellum Development Ventricular System Development Negative Regulation Of Histone Methylation Cardiolipin Metabolic Process Negative Regulation Of Histone Acetylation Social Behavior Neuron Maturation Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Phosphatidylcholine Metabolic Process Catecholamine Secretion Positive Regulation Of Synapse Assembly Regulation Of Excitatory Postsynaptic Membrane Potential Long-term Synaptic Potentiation	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Transcription, DNA-templated Maintenance Of DNA Methylation Gene Expression Positive Regulation Of Gene Expression Gene Silencing Chromatin Modification DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine
Pathways			NoRC negatively regulates rRNA expression Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA DNA methylation
Drugs			Azacitidine Procainamide Flucytosine Decitabine
Diseases
GWAS		Red blood cell traits ( 23446634)
Protein-Protein Interactions		17 interactors: DNMT1 GTF2B HDAC1 HIPK2 HIST2H3A HMGB1 LBR NCOR1 PRPF40A PRPF40B RNF4 SIN3A SKI SMARCA2 SMARCB1 SOX18 SPI1	31 interactors: AKT1 BAZ2A CBX1 CSNK2B DAXX DMAP1 DNMT3A DNMT3B DYNLL1 EED EZH2 GSK3B HDAC1 HDAC2 HELLS HMGB1 MECP2 NRIP1 PCNA RB1 RGS6 RPS6KA6 RUNX1 RUNX1T1 SETD7 SUV39H1 TRIM27 TSG101 UHRF1 USP7 YWHAQ
Entrez ID		4204	1786
HPRD ID		02050	00532
Ensembl ID		ENSG00000169057	ENSG00000130816
Uniprot IDs		D3YJ43 P51608 Q59FJ6	I6L9H2 P26358
PDB IDs		1QK9 3C2I	3EPZ 3PTA 3SWR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Transcription, DNA-templated Chromatin Modification Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Chromosome Organization Positive Regulation Of Cellular Metabolic Process Chromatin Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Histone Modification Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Positive Regulation Of Metabolic Process Regulation Of Gene Expression, Epigenetic Regulation Of DNA Binding Cellular Macromolecule Biosynthetic Process Negative Regulation Of Chromosome Organization Macromolecule Biosynthetic Process Biosynthetic Process Regulation Of Cellular Component Organization Positive Regulation Of DNA Binding Transforming Growth Factor Beta Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Chromatin Remodeling Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Chromatin Modification Negative Regulation Of Gene Expression Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromosome Organization Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Chromatin Silencing Organelle Organization Histone Modification DNA Methylation Gene Expression Methylation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Modification Nitrogen Compound Metabolic Process Transcription, DNA-templated Gene Silencing Chromatin Remodeling RNA Biosynthetic Process Regulation Of Gene Expression By Genetic Imprinting Cellular Macromolecule Biosynthetic Process Regulation Of Cellular Process RNA Metabolic Process Macromolecule Biosynthetic Process Genetic Imprinting Developmental Process Cell Cycle Histone Methylation Regulation Of Organelle Organization Multicellular Organismal Development Cellular Response To Stimulus Cellular Response To Stress Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		ache ahr antimirs arguing cholinergic cns correlates creb detrusor ep300 influences jarid1a limits micrornas mimics mir mirna mirnas nuclei obstruction outlet outside plasticity pnkd referenced synapse transfection unrelated urethra	cpg cues de dense dnmt3a dnmt3b dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Difference) ?		ache ahr antimirs arguing cholinergic cns correlates creb detrusor ep300 influences jarid1a limits micrornas mimics mir mirna mirnas nuclei obstruction outlet outside plasticity pnkd referenced synapse transfection unrelated urethra	cpg cues de dense dnmt3a dnmt3b dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Intersection) ?