MECP2 and SOX18

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MECP2	SOX18
Description		methyl-CpG binding protein 2	SRY-box transcription factor 18
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Heterochromatin Extracellular Space Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Synapse Postsynapse	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Nucleic Acid Binding DNA Binding Chromatin Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding SiRNA Binding Molecular Adaptor Activity Histone Reader Activity Molecular Condensate Scaffold Activity Promoter-specific Chromatin Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Behavioral Fear Response Response To Hypoxia Startle Response Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Respiratory Gaseous Exchange By Nervous System Process Inositol Metabolic Process Regulation Of Transcription By RNA Polymerase II Glutamine Metabolic Process Biogenic Amine Metabolic Process Notch Signaling Pathway Chemical Synaptic Transmission Synapse Assembly Brain Development Respiratory Gaseous Exchange By Respiratory System Learning Memory Long-term Memory Intracellular Protein Localization Glucocorticoid Metabolic Process Cell Population Proliferation Associative Learning Adult Locomotory Behavior Visual Learning Post-embryonic Development Gene Expression Regulation Of Gene Expression Negative Regulation Of Gene Expression Glial Cell Proliferation Dendrite Development Negative Regulation Of Angiogenesis Proprioception Sensory Perception Of Pain Cerebellum Development Ventricular System Development Neuron Differentiation Neuron Projection Development Heterochromatin Formation Cardiolipin Metabolic Process Multicellular Organismal Response To Stress Social Behavior Epigenetic Regulation Of Gene Expression Neuron Maturation Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Phosphatidylcholine Metabolic Process Regulation Of Synaptic Plasticity Cell Development Catecholamine Secretion Neuromuscular Process Controlling Posture Neuromuscular Process Negative Regulation Of Developmental Process Negative Regulation Of Smooth Muscle Cell Differentiation Response To Other Organism Excitatory Postsynaptic Potential Positive Regulation Of Glial Cell Proliferation Long-term Synaptic Potentiation Genomic Imprinting Positive Regulation Of Microtubule Nucleation Trans-synaptic Signaling By BDNF Regulation Of Multicellular Organismal Development	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Blood Vessel Development Vasculogenesis In Utero Embryonic Development Hair Follicle Development Vasculature Development Lymph Vessel Development Lymphangiogenesis Heart Looping Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Heart Development Tissue Development Hair Cycle Process Embryonic Heart Tube Development Blood Vessel Endothelial Cell Migration Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Anatomical Structure Formation Involved In Morphogenesis Stem Cell Fate Specification Endocardium Formation Lymphatic Endothelial Cell Differentiation Endocardial Cell Differentiation Establishment Of Endothelial Barrier Regulation Of Stem Cell Proliferation
Pathways
Drugs
Diseases		Non-syndromic X-linked mental retardation Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS) Rett syndrome	Lymphedemas, including: Lymphedema, hereditary I; Lymphedema-distichiasis syndrome (LD); Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS)
GWAS		Non-albumin protein levels ( 29403010) Red blood cell traits ( 23446634) Schizophrenia ( 24043878) Systemic lupus erythematosus ( 19838195 26502338 26663301)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Refractive error ( 32231278)
Interacting Genes		17 interacting genes: DNMT1 DNMT3L GTF2B H3C15 HIPK2 HMGB1 NCOR1 PRPF40A PRPF40B SIN3A SKI SMARCA2 SMARCB1 SOX18 SPI1 TBL1X TBL1XR1	5 interacting genes: AURKA GKAP1 HMGB1 MECP2 MEF2C
Entrez ID		4204	54345
HPRD ID		02050	07208
Ensembl ID		ENSG00000169057	ENSG00000203883
Uniprot IDs		A0A140VKC4 D3YJ43 P51608 Q59FJ6	P35713
PDB IDs		1QK9 3C2I 5BT2 6C1Y 6OGJ 6OGK 6YWW 8AJR 8ALQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Transcription Repressor Complex Epigenetic Regulation Of Gene Expression Chromatin Remodeling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Negative Regulation Of Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone Deacetylase Complex Nucleoplasm Regulation Of RNA Metabolic Process Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic DNA Binding Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Germ Cell Nucleus Regulation Of Nucleotide-excision Repair Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA Binding Positive Regulation Of Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Metabolic Process Cellular Developmental Process Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Leukocyte Differentiation	Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Cell Development Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Cell Differentiation Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Locomotion Negative Regulation Of Cell Migration Negative Regulation Of Gene Expression Negative Regulation Of Cell Motility Excitatory Postsynaptic Potential Positive Regulation Of Developmental Process Positive Regulation Of Cell Development Animal Organ Development Calcium-dependent Protein Kinase Regulator Activity Regulation Of Cell Differentiation Regulation Of Restriction Endodeoxyribonuclease Activity Regulation Of Apoptotic Process Positive Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of Programmed Cell Death Regulation Of Cell Communication Regulation Of Signaling Regulation Of Postsynaptic Membrane Potential Sinoatrial Valve Morphogenesis Chromatin Remodeling Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Apoptotic Cell Clearance Muscle Cell Fate Determination Nephron Tubule Epithelial Cell Differentiation Cellular Response To Trichostatin A Regulation Of Mismatch Repair C-X-C Chemokine Binding Plasma Membrane Bounded Cell Projection Organization Alphav-beta3 Integrin-HMGB1 Complex Chromatin Organization T-helper 1 Cell Activation Epithelial Cell Proliferation Positive Regulation Of Mismatch Repair Positive Regulation Of Lymphocyte Proliferation Plasmacytoid Dendritic Cell Activation Heterochromatin Formation Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Cell Development
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