MECP2 and SOX18

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MECP2	SOX18
Gene Name		methyl CpG binding protein 2	SRY (sex determining region Y)-box 18
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Heterochromatin Extracellular Space Nucleus Nucleoplasm Cytosol	Nuclear Chromatin Nucleus Nuclear Transcription Factor Complex
	Molecular Function	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity MRNA Binding Protein Binding Transcription Factor Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Protein Domain Specific Binding SiRNA Binding Poly(A) RNA Binding Protein N-terminus Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Behavioral Fear Response Response To Hypoxia Startle Response Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Respiratory Gaseous Exchange By Neurological System Process Inositol Metabolic Process Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Transcription, DNA-templated Glutamine Metabolic Process Synapse Assembly Respiratory Gaseous Exchange Long-term Memory Protein Localization Glucocorticoid Metabolic Process Positive Regulation Of Cell Proliferation Adult Locomotory Behavior Visual Learning Pathogenesis Post-embryonic Development Dendrite Development Histone Methylation Histone Acetylation Proprioception Sensory Perception Of Pain Cerebellum Development Ventricular System Development Negative Regulation Of Histone Methylation Cardiolipin Metabolic Process Negative Regulation Of Histone Acetylation Social Behavior Neuron Maturation Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Phosphatidylcholine Metabolic Process Catecholamine Secretion Positive Regulation Of Synapse Assembly Regulation Of Excitatory Postsynaptic Membrane Potential Long-term Synaptic Potentiation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Vasculogenesis In Utero Embryonic Development Hair Follicle Development Vasculature Development Lymphangiogenesis Heart Looping Outflow Tract Morphogenesis Hair Cycle Process Embryonic Heart Tube Development MRNA Transcription From RNA Polymerase II Promoter Blood Vessel Endothelial Cell Migration Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Stem Cell Fate Specification Endocardium Formation Lymphatic Endothelial Cell Differentiation Endocardial Cell Differentiation Establishment Of Endothelial Barrier Regulation Of Stem Cell Proliferation
Pathways
Drugs
Diseases
GWAS		Red blood cell traits ( 23446634)
Protein-Protein Interactions		17 interactors: DNMT1 GTF2B HDAC1 HIPK2 HIST2H3A HMGB1 LBR NCOR1 PRPF40A PRPF40B RNF4 SIN3A SKI SMARCA2 SMARCB1 SOX18 SPI1	4 interactors: GKAP1 HMGB1 MECP2 MEF2C
Entrez ID		4204	54345
HPRD ID		02050	07208
Ensembl ID		ENSG00000169057	ENSG00000203883
Uniprot IDs		D3YJ43 P51608 Q59FJ6	P35713
PDB IDs		1QK9 3C2I
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Transcription, DNA-templated Chromatin Modification Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Chromosome Organization Positive Regulation Of Cellular Metabolic Process Chromatin Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Histone Modification Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Positive Regulation Of Metabolic Process Regulation Of Gene Expression, Epigenetic Regulation Of DNA Binding Cellular Macromolecule Biosynthetic Process Negative Regulation Of Chromosome Organization Macromolecule Biosynthetic Process Biosynthetic Process Regulation Of Cellular Component Organization Positive Regulation Of DNA Binding Transforming Growth Factor Beta Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Chromatin Remodeling Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta	Regulation Of Synapse Assembly Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Membrane Depolarization Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Binding Negative Regulation Of Apoptotic Cell Clearance Neuron Development Regulation Of Synaptic Plasticity Negative Regulation Of Neuron Apoptotic Process Primary Heart Field Specification Sinoatrial Valve Morphogenesis Regulation Of Synaptic Activity Cellular Response To Trichostatin A Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Neuron Differentiation Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Neuron Death Nephron Tubule Epithelial Cell Differentiation Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis Muscle Cell Fate Determination Regulation Of Neuron Apoptotic Process Catecholamine Secretion Negative Regulation Of DNA-templated Transcription, Initiation Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Binding Defense Response Negative Regulation Of Biosynthetic Process Learning Or Memory Regulation Of Membrane Potential Positive Regulation Of Macrophage Apoptotic Process Base-excision Repair, DNA Ligation Positive Regulation Of Behavioral Fear Response Proprioception Regulation Of Neuron Death Cognition Regulation Of Apoptotic Process Regulation Of Synaptic Transmission Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Generation Of Neurons Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		ache ahr antimirs arguing cholinergic cns correlates creb detrusor ep300 influences jarid1a limits micrornas mimics mir mirna mirnas nuclei obstruction outlet outside plasticity pnkd referenced synapse transfection unrelated urethra	bo2 br bt capture counts ductal exact follicle grade grades hair healing idc ihc intratumoral lymphatic malignancy mb mda microdissection microvessel mvc peritumoral positivity sk sox17 sox7 vessel vessels
Tagcloud (Difference) ?		ache ahr antimirs arguing cholinergic cns correlates creb detrusor ep300 influences jarid1a limits micrornas mimics mir mirna mirnas nuclei obstruction outlet outside plasticity pnkd referenced synapse transfection unrelated urethra	bo2 br bt capture counts ductal exact follicle grade grades hair healing idc ihc intratumoral lymphatic malignancy mb mda microdissection microvessel mvc peritumoral positivity sk sox17 sox7 vessel vessels
Tagcloud (Intersection) ?