MECP2 and HIST2H3A

Number of citations of the paper that reports this interaction (PMID 12427740)
165

Data Source:
BioGRID (pull down)

		MECP2	HIST2H3A
Gene Name		methyl CpG binding protein 2	histone cluster 2, H3a
Image
Gene Ontology Annotations	Cellular Component	Heterochromatin Extracellular Space Nucleus Nucleoplasm Cytosol	Nucleosome Extracellular Region Nucleus Nucleoplasm Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity MRNA Binding Protein Binding Transcription Factor Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Protein Domain Specific Binding SiRNA Binding Poly(A) RNA Binding Protein N-terminus Binding	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Behavioral Fear Response Response To Hypoxia Startle Response Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Respiratory Gaseous Exchange By Neurological System Process Inositol Metabolic Process Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Transcription, DNA-templated Glutamine Metabolic Process Synapse Assembly Respiratory Gaseous Exchange Long-term Memory Protein Localization Glucocorticoid Metabolic Process Positive Regulation Of Cell Proliferation Adult Locomotory Behavior Visual Learning Pathogenesis Post-embryonic Development Dendrite Development Histone Methylation Histone Acetylation Proprioception Sensory Perception Of Pain Cerebellum Development Ventricular System Development Negative Regulation Of Histone Methylation Cardiolipin Metabolic Process Negative Regulation Of Histone Acetylation Social Behavior Neuron Maturation Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Phosphatidylcholine Metabolic Process Catecholamine Secretion Positive Regulation Of Synapse Assembly Regulation Of Excitatory Postsynaptic Membrane Potential Long-term Synaptic Potentiation	Chromatin Silencing At RDNA Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways			RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS		Red blood cell traits ( 23446634)
Protein-Protein Interactions		17 interactors: DNMT1 GTF2B HDAC1 HIPK2 HIST2H3A HMGB1 LBR NCOR1 PRPF40A PRPF40B RNF4 SIN3A SKI SMARCA2 SMARCB1 SOX18 SPI1	16 interactors: CBX5 DNTTIP2 EHMT2 GTF3C4 HDAC9 ING1 KDM5A KDM5C LALBA MECP2 PADI4 PRDM1 PRMT6 SETDB1 SUV39H1 UHRF1
Entrez ID		4204	333932
HPRD ID		02050
Ensembl ID		ENSG00000169057
Uniprot IDs		D3YJ43 P51608 Q59FJ6	Q71DI3
PDB IDs		1QK9 3C2I	2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Transcription, DNA-templated Chromatin Modification Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Chromosome Organization Positive Regulation Of Cellular Metabolic Process Chromatin Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Histone Modification Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Positive Regulation Of Metabolic Process Regulation Of Gene Expression, Epigenetic Regulation Of DNA Binding Cellular Macromolecule Biosynthetic Process Negative Regulation Of Chromosome Organization Macromolecule Biosynthetic Process Biosynthetic Process Regulation Of Cellular Component Organization Positive Regulation Of DNA Binding Transforming Growth Factor Beta Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Chromatin Remodeling Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta	Chromatin Modification Chromatin Organization Histone Modification Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Methylation Regulation Of RNA Metabolic Process Histone H3-K9 Modification Negative Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Histone Methylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organelle Organization RNA Metabolic Process Peptidyl-amino Acid Modification Protein Methylation Gene Expression Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone H3-K9 Methylation Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Protein Modification Process Regulation Of Gene Expression, Epigenetic Histone H3-K9 Trimethylation Histone Lysine Methylation Peptidyl-lysine Dimethylation DNA Methylation On Cytosine Peptidyl-lysine Methylation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Metabolic Process Peptidyl-lysine Trimethylation Chromatin Silencing Regulation Of Cellular Process
Tagcloud ?		ache ahr antimirs arguing cholinergic cns correlates creb detrusor ep300 influences jarid1a limits micrornas mimics mir mirna mirnas nuclei obstruction outlet outside plasticity pnkd referenced synapse transfection unrelated urethra
Tagcloud (Difference) ?		ache ahr antimirs arguing cholinergic cns correlates creb detrusor ep300 influences jarid1a limits micrornas mimics mir mirna mirnas nuclei obstruction outlet outside plasticity pnkd referenced synapse transfection unrelated urethra
Tagcloud (Intersection) ?