MECP2 and TBL1XR1

Number of citations of the paper that reports this interaction (PubMedID 36890145)
50

Data Source:
BioGRID (affinity chromatography technology, pull down, x-ray crystallography, protein complementation assay)

		MECP2	TBL1XR1
Description		methyl-CpG binding protein 2	TBL1X/Y related 1
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GO Annotations	Cellular Component	Chromatin Heterochromatin Extracellular Space Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Synapse Postsynapse	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Repressor Complex Mitotic Spindle
	Molecular Function	Nucleic Acid Binding DNA Binding Chromatin Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding SiRNA Binding Molecular Adaptor Activity Histone Reader Activity Molecular Condensate Scaffold Activity Promoter-specific Chromatin Binding	Transcription Cis-regulatory Region Binding DNA Binding Transcription Corepressor Activity Protein Binding Beta-catenin Binding Histone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Behavioral Fear Response Response To Hypoxia Startle Response Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Respiratory Gaseous Exchange By Nervous System Process Inositol Metabolic Process Regulation Of Transcription By RNA Polymerase II Glutamine Metabolic Process Biogenic Amine Metabolic Process Notch Signaling Pathway Chemical Synaptic Transmission Synapse Assembly Brain Development Respiratory Gaseous Exchange By Respiratory System Learning Memory Long-term Memory Intracellular Protein Localization Glucocorticoid Metabolic Process Cell Population Proliferation Associative Learning Adult Locomotory Behavior Visual Learning Post-embryonic Development Gene Expression Regulation Of Gene Expression Negative Regulation Of Gene Expression Glial Cell Proliferation Dendrite Development Negative Regulation Of Angiogenesis Proprioception Sensory Perception Of Pain Cerebellum Development Ventricular System Development Neuron Differentiation Neuron Projection Development Heterochromatin Formation Cardiolipin Metabolic Process Multicellular Organismal Response To Stress Social Behavior Epigenetic Regulation Of Gene Expression Neuron Maturation Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Phosphatidylcholine Metabolic Process Regulation Of Synaptic Plasticity Cell Development Catecholamine Secretion Neuromuscular Process Controlling Posture Neuromuscular Process Negative Regulation Of Developmental Process Negative Regulation Of Smooth Muscle Cell Differentiation Response To Other Organism Excitatory Postsynaptic Potential Positive Regulation Of Glial Cell Proliferation Long-term Synaptic Potentiation Genomic Imprinting Positive Regulation Of Microtubule Nucleation Trans-synaptic Signaling By BDNF Regulation Of Multicellular Organismal Development	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Hatching Response To Dietary Excess Chromatin Organization Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Lipid Catabolic Process Multicellular Organism Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II White Fat Cell Differentiation Adipose Tissue Development Fat Pad Development Regulation Of Triglyceride Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events Cytoprotection by HMOX1 Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs
Diseases		Non-syndromic X-linked mental retardation Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS) Rett syndrome
GWAS		Non-albumin protein levels ( 29403010) Red blood cell traits ( 23446634) Schizophrenia ( 24043878) Systemic lupus erythematosus ( 19838195 26502338 26663301)	Asthma ( 34103634 32296059 31959851 31619474 30929738) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) ( 32595297) Central corneal thickness ( 31798171 32528159 29760442) Chin dimples ( 27182965) Chronotype ( 30696823) Corneal structure ( 23291589) Early chronic obstructive pulmonary disease in never smokers ( 33235445) Esophageal cancer ( 21642993) Inflammatory skin disease ( 25574825) Mastocytosis (KIT D816V positive) ( 33421400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Pulse pressure ( 30224653) Red cell distribution width ( 32888494)
Interacting Genes		17 interacting genes: DNMT1 DNMT3L GTF2B H3C15 HIPK2 HMGB1 NCOR1 PRPF40A PRPF40B SIN3A SKI SMARCA2 SMARCB1 SOX18 SPI1 TBL1X TBL1XR1	15 interacting genes: ARL2 CEBPA CORO2A DDB1 FOXK2 GPS2 H2BC21 H4C14 H4C6 HDAC3 MECP2 NCOR1 OGT TBL1X UBE2I
Entrez ID		4204	79718
HPRD ID		02050	15476
Ensembl ID		ENSG00000169057	ENSG00000177565
Uniprot IDs		A0A140VKC4 D3YJ43 P51608 Q59FJ6	C9JLJ1 Q9BZK7
PDB IDs		1QK9 3C2I 5BT2 6C1Y 6OGJ 6OGK 6YWW 8AJR 8ALQ	4LG9
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Transcription Repressor Complex Epigenetic Regulation Of Gene Expression Chromatin Remodeling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Negative Regulation Of Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone Deacetylase Complex Nucleoplasm Regulation Of RNA Metabolic Process Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic DNA Binding Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Germ Cell Nucleus Regulation Of Nucleotide-excision Repair Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA Binding Positive Regulation Of Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Metabolic Process Cellular Developmental Process Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Leukocyte Differentiation	Transcription Repressor Complex Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Developmental Process Negative Regulation Of RNA Metabolic Process Transcription Corepressor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of JNK Cascade Cellular Component Assembly Regulation Of Small Molecule Metabolic Process Histone Deacetylase Complex Nucleus Regulation Of Glycolytic Process Chromatin Remodeling Negative Regulation Of Cell Differentiation DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Biosynthetic Process Regulation Of ATP Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Purine Nucleotide Metabolic Process Structural Constituent Of Chromatin Chromatin DNA Binding Regulation Of Transcription By RNA Polymerase II Rhythmic Process Transcription Cis-regulatory Region Binding Spindle Assembly Negative Regulation Of Macromolecule Metabolic Process Membraneless Organelle Assembly Regulation Of Glucose Metabolic Process CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Nucleosome Assembly Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Metabolic Process Nucleosome Histone Deacetylase Binding Protein Heterodimerization Activity Nucleosome Organization Regulation Of Generation Of Precursor Metabolites And Energy Circadian Rhythm Mitotic Spindle Regulation Of Nucleobase-containing Compound Metabolic Process Maintenance Of Protein Location In Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription
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