MAG and COL4A1

Number of citations: 56 (PubMedID 2446864)
Data Source: BioGRID (pull down)

		MAG	COL4A1
Name		myelin associated glycoprotein	collagen type IV alpha 1 chain
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Paranode Region Of Axon Myelin Sheath Adaxonal Region Myelin Sheath Compact Myelin Schmidt-Lanterman Incisure Membrane Raft Mesaxon	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Signaling Receptor Binding Lipid Binding Protein Kinase Binding Carbohydrate Binding Sialic Acid Binding Protein Homodimerization Activity Ganglioside GT1b Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Platelet-derived Growth Factor Binding
	Biological Process	Cell Adhesion Nervous System Development Negative Regulation Of Neuron Projection Development Transmission Of Nerve Impulse Substantia Nigra Development Central Nervous System Myelination Negative Regulation Of Axon Extension Axon Regeneration Positive Regulation Of Myelination Central Nervous System Myelin Formation Myelination Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Astrocyte Differentiation Cellular Response To Mechanical Stimulus Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Brain Development Neuromuscular Junction Development Epithelial Cell Differentiation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Blood Vessel Morphogenesis Retinal Blood Vessel Morphogenesis Renal Tubule Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization
Pathways		Axonal growth inhibition (RHOA activation) Basigin interactions EGR2 and SOX10-mediated initiation of Schwann cell myelination	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells
Diseases		None	Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC) Brain small vessel disease with Axenfeld-Rieger anomaly Porencephaly
GWAS		No GWAS studies recorded	Age-related nuclear cataracts ( 24951543 ) Arterial stiffness ( 20031579 ) Behavioral disturbance or psychiatric symptoms and prion disease ( 25897833 ) Coronary artery disease ( 32469254 33020668 24262325 26343387 29212778 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Coronary heart disease ( 21378990 ) Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133 ) Estimated glomerular filtration rate after 1 year in renal transplantation (donor effect) ( 30920136 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Intraocular pressure ( 31959993 29785010 ) Lateral ventricle volume ( 31530798 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Lymphocyte count ( 32888494 ) Mean platelet volume ( 32888494 ) Metabolite levels ( 23823483 ) Monocyte count ( 32888494 27863252 ) Myocardial infarction ( 33532862 26343387 ) Night sleep phenotypes ( 27126917 ) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377 ) Obesity-related traits ( 23251661 ) Peripheral artery disease ( 31285632 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 32888494 ) Pulse pressure ( 30578418 ) Stroke ( 30383316 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 28552196 34021172 )
Novel Interactors		None recorded	1 novel interactors: CXCR4
Interacting Genes		18 interacting genes: APP COL1A1 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 COL9A1 COL9A2 COL9A3 FN1 FYN MAP1B MBP NGFR PLP1 PRNP RTN4R	30 interacting genes: ACHE APCS APP BGN BMP3 CD93 COL18A1 COL4A2 COL7A1 DCN DISC1 FBLN2 FN1 HABP2 MAG MATN2 MMP9 NID1 NID2 OSM PDGFA PDGFB SAA1 SAA2 SAA4 SERPINE2 SMAD1 TGFBI TGM2 THBS1
Entrez ID		4099	1282
HPRD ID		01160	00359
Ensembl ID		ENSG00000105695	ENSG00000187498
Uniprot IDs		P20916 Q53ES7	A5PKV2 P02462
PDB IDs		Not available	1LI1 5NAX 5NAY 6MPX
GO Terms Enriched among Interactors		Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen Trimer Platelet-derived Growth Factor Binding Endoplasmic Reticulum Lumen Extracellular Matrix Fibrillar Collagen Trimer Basement Membrane Collagen Type IX Trimer Extracellular Matrix Structural Constituent Anatomical Structure Morphogenesis Skin Development Extracellular Matrix Organization Extracellular Structure Organization Collagen Fibril Organization System Development Cellular Response To Amino Acid Stimulus Protease Binding Extracellular Region Response To Amino Acid Cellular Response To Amyloid-beta Regulation Of Dendritic Spine Maintenance Developmental Process Proteoglycan Binding Regulation Of Postsynapse Organization Perikaryon Response To Amyloid-beta Animal Organ Morphogenesis Response To Mechanical Stimulus Cartilage Development Basement Membrane Organization Type 5 Metabotropic Glutamate Receptor Binding Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Growth Factor Receptor Binding Response To Xenobiotic Stimulus Collagen Type XI Trimer Negative Regulation Of Dendritic Spine Maintenance Neuron Projection Organization Regulation Of Synapse Organization Growth Cone Integrin Binding Response To Growth Factor Blood Vessel Development Central Nervous System Development Sensory Perception Of Mechanical Stimulus Nervous System Process Heparin Binding Homeostatic Process Limb Joint Morphogenesis Cellular Developmental Process	Extracellular Region Extracellular Matrix Basement Membrane Collagen Binding Extracellular Matrix Structural Constituent Extracellular Space Extracellular Matrix Binding Acute-phase Response Extracellular Exosome Cell Adhesion Endoplasmic Reticulum Lumen Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis High-density Lipoprotein Particle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Glycosaminoglycan Binding Regulation Of Cell Adhesion Acute Inflammatory Response Platelet Alpha Granule Lumen Regulation Of Developmental Process Extracellular Matrix Organization Extracellular Structure Organization Developmental Process Endodermal Cell Differentiation Calcium Ion Binding Golgi Lumen Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Proteoglycan Binding Response To Wounding Regulation Of Cell-substrate Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Neurogenesis Regulation Of Multicellular Organismal Development Positive Regulation Of Cell-substrate Adhesion Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Inflammatory Response Negative Regulation Of Platelet Activation Regulation Of Wound Healing Platelet Alpha Granule Positive Regulation Of Cell Communication Positive Regulation Of Signaling Laminin Binding Negative Regulation Of Wound Healing Bone Development Positive Regulation Of Nervous System Development