MAG and COL9A3

Number of citations of the paper that reports this interaction (PubMedID 2446864)
56

Data Source:
HPRD (in vivo)

		MAG	COL9A3
Description		myelin associated glycoprotein	collagen type IX alpha 3 chain
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Paranode Region Of Axon Myelin Sheath Adaxonal Region Myelin Sheath Compact Myelin Schmidt-Lanterman Incisure Membrane Raft Mesaxon	Extracellular Region Collagen Trimer Collagen Type IX Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Signaling Receptor Binding Lipid Binding Protein Kinase Binding Carbohydrate Binding Sialic Acid Binding Protein Homodimerization Activity Ganglioside GT1b Binding	Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein Homodimerization Activity
	Biological Process	Cell Adhesion Nervous System Development Negative Regulation Of Neuron Projection Development Transmission Of Nerve Impulse Substantia Nigra Development Central Nervous System Myelination Negative Regulation Of Axon Extension Axon Regeneration Positive Regulation Of Myelination Central Nervous System Myelin Formation Myelination Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Astrocyte Differentiation Cellular Response To Mechanical Stimulus Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Pathways		Axonal growth inhibition (RHOA activation) Basigin interactions EGR2 and SOX10-mediated initiation of Schwann cell myelination	Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization
Drugs
Diseases			Multiple epiphyseal dysplasia (MED)
GWAS
Interacting Genes		18 interacting genes: APP COL1A1 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 COL9A1 COL9A2 COL9A3 FN1 FYN MAP1B MBP NGFR PLP1 PRNP RTN4R	4 interacting genes: COL2A1 EGFR ERBB2 MAG
Entrez ID		4099	1299
HPRD ID		01160	00374
Ensembl ID		ENSG00000105695	ENSG00000092758
Uniprot IDs		P20916 Q53ES7	Q14050
PDB IDs			5CTD 5CTI 5CVA 5CVB
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen Trimer Platelet-derived Growth Factor Binding Endoplasmic Reticulum Lumen Extracellular Matrix Fibrillar Collagen Trimer Basement Membrane Collagen Type IX Trimer Extracellular Matrix Structural Constituent Anatomical Structure Morphogenesis Skin Development Extracellular Matrix Organization Extracellular Structure Organization Collagen Fibril Organization System Development Cellular Response To Amino Acid Stimulus Protease Binding Extracellular Region Response To Amino Acid Cellular Response To Amyloid-beta Regulation Of Dendritic Spine Maintenance Developmental Process Proteoglycan Binding Regulation Of Postsynapse Organization Perikaryon Response To Amyloid-beta Animal Organ Morphogenesis Response To Mechanical Stimulus Cartilage Development Basement Membrane Organization Type 5 Metabotropic Glutamate Receptor Binding Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Growth Factor Receptor Binding Response To Xenobiotic Stimulus Collagen Type XI Trimer Negative Regulation Of Dendritic Spine Maintenance Neuron Projection Organization Regulation Of Synapse Organization Growth Cone Integrin Binding Response To Growth Factor Blood Vessel Development Central Nervous System Development Sensory Perception Of Mechanical Stimulus Nervous System Process Heparin Binding Homeostatic Process Limb Joint Morphogenesis Cellular Developmental Process	ERBB2-EGFR Signaling Pathway Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process ERBB2 Signaling Pathway Cellular Response To Growth Factor Stimulus Myelin Sheath Response To Growth Factor Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Cell Growth Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane ERBB Signaling Pathway Ruffle Membrane Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Growth Myelination Axon Ensheathment Negative Regulation Of Cell Differentiation Multivesicular Body, Internal Vesicle Lumen Ossification Protein Tyrosine Kinase Activity Embryonic Organ Development Nervous System Process Positive Regulation Of Cell Growth Shc-EGFR Complex ERBB3:ERBB2 Complex Mesaxon Collagen Type II Trimer Negative Regulation Of Developmental Process Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity RNA Polymerase I Core Binding Ganglioside GT1b Binding Receptor Complex System Development Positive Regulation Of Epithelial Cell Proliferation Response To Wounding Membrane Raft Epidermal Growth Factor Binding Compact Myelin Collagen Type XI Trimer Anterior Head Development Regulation Of Protein Kinase C Signaling Transmembrane Signaling Receptor Activity Positive Regulation Of Protein Phosphorylation Basolateral Plasma Membrane
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