MAG and COL9A2

Number of citations of the paper that reports this interaction (PubMedID 2446864)
56

Data Source:
HPRD (in vivo)

		MAG	COL9A2
Description		myelin associated glycoprotein	collagen type IX alpha 2 chain
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Paranode Region Of Axon Myelin Sheath Adaxonal Region Myelin Sheath Compact Myelin Schmidt-Lanterman Incisure Membrane Raft Mesaxon	Extracellular Region Collagen Trimer Collagen Type IX Trimer Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Signaling Receptor Binding Lipid Binding Protein Kinase Binding Carbohydrate Binding Sialic Acid Binding Protein Homodimerization Activity Ganglioside GT1b Binding	Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein Homodimerization Activity
	Biological Process	Cell Adhesion Nervous System Development Negative Regulation Of Neuron Projection Development Transmission Of Nerve Impulse Substantia Nigra Development Central Nervous System Myelination Negative Regulation Of Axon Extension Axon Regeneration Positive Regulation Of Myelination Central Nervous System Myelin Formation Myelination Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Astrocyte Differentiation Cellular Response To Mechanical Stimulus Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules	Skeletal System Development
Pathways		Axonal growth inhibition (RHOA activation) Basigin interactions EGR2 and SOX10-mediated initiation of Schwann cell myelination	Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization
Drugs
Diseases			Multiple epiphyseal dysplasia (MED)
GWAS			Appendicular lean mass ( 33097823) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		18 interacting genes: APP COL1A1 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 COL9A1 COL9A2 COL9A3 FN1 FYN MAP1B MBP NGFR PLP1 PRNP RTN4R	10 interacting genes: COL2A1 ERBB2 FEZ1 HAP1 MAG MEOX2 MTNR1A NOA1 UBQLN1 UBQLN2
Entrez ID		4099	1298
HPRD ID		01160	00373
Ensembl ID		ENSG00000105695	ENSG00000049089
Uniprot IDs		P20916 Q53ES7	Q14055
PDB IDs			5CTD 5CTI 5CVA 5CVB
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen Trimer Platelet-derived Growth Factor Binding Endoplasmic Reticulum Lumen Extracellular Matrix Fibrillar Collagen Trimer Basement Membrane Collagen Type IX Trimer Extracellular Matrix Structural Constituent Anatomical Structure Morphogenesis Skin Development Extracellular Matrix Organization Extracellular Structure Organization Collagen Fibril Organization System Development Cellular Response To Amino Acid Stimulus Protease Binding Extracellular Region Response To Amino Acid Cellular Response To Amyloid-beta Regulation Of Dendritic Spine Maintenance Developmental Process Proteoglycan Binding Regulation Of Postsynapse Organization Perikaryon Response To Amyloid-beta Animal Organ Morphogenesis Response To Mechanical Stimulus Cartilage Development Basement Membrane Organization Type 5 Metabotropic Glutamate Receptor Binding Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Growth Factor Receptor Binding Response To Xenobiotic Stimulus Collagen Type XI Trimer Negative Regulation Of Dendritic Spine Maintenance Neuron Projection Organization Regulation Of Synapse Organization Growth Cone Integrin Binding Response To Growth Factor Blood Vessel Development Central Nervous System Development Sensory Perception Of Mechanical Stimulus Nervous System Process Heparin Binding Homeostatic Process Limb Joint Morphogenesis Cellular Developmental Process	Regulation Of Organelle Transport Along Microtubule Autophagosome Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Cellular Response To Growth Factor Stimulus Regulation Of Microtubule-based Process Myelin Sheath Regulation Of Microtubule-based Movement Autophagy Positive Regulation Of Neurotrophin Production Regulation Of Organelle Assembly Mitochondrion Localization Regulation Of Autophagosome Assembly Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Regulation Of Vacuole Organization Regulation Of Macroautophagy Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Store-operated Calcium Channel Activity Response To Growth Factor Roof Of Mouth Development Signaling Receptor Binding ERBB3:ERBB2 Complex Cytoplasmic Vesicle Myelination Axon Ensheathment Mesaxon Regulation Of Transmembrane Transporter Activity Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Autophagy Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Negative Regulation Of G Protein-coupled Receptor Internalization Collagen Type II Trimer RNA Polymerase I Core Binding Ganglioside GT1b Binding Brain-derived Neurotrophic Factor Binding Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Autophagosome Organization Negative Regulation Of Toll-like Receptor 3 Signaling Pathway System Development Positive Regulation Of Proteasomal Protein Catabolic Process Collagen Type XI Trimer Anterior Head Development Negative Regulation Of Immature T Cell Proliferation In Thymus Neuron Projection Development ErbB-3 Class Receptor Binding Regulation Of Cellular Localization
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