NEDD4L and IFRD2

Number of citations of the paper that reports this interaction (PubMedID 19953087)
60

Data Source:
BioGRID (pull down)

		NEDD4L	IFRD2
Description		NEDD4 like E3 ubiquitin protein ligase	interferon related developmental regulator 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Multivesicular Body Golgi Apparatus Cytosol Plasma Membrane Apical Plasma Membrane Extracellular Exosome	Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Sodium Channel Inhibitor Activity Transmembrane Transporter Binding Ubiquitin Protein Ligase Activity	Protein Binding Translation Repressor Activity Ribosome Binding
	Biological Process	Regulation Of Membrane Depolarization Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Monoatomic Ion Transport Neuromuscular Junction Development Protein Ubiquitination Cell Differentiation Neuron Projection Development Receptor Internalization Regulation Of Protein Stability Receptor Catabolic Process Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Regulation Of Membrane Repolarization Regulation Of Biological Quality Protein K48-linked Ubiquitination Ventricular Cardiac Muscle Cell Action Potential Sodium Ion Import Across Plasma Membrane Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Dendrite Extension Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Caveolin-mediated Endocytosis	Regulation Of Translation Wnt Signaling Pathway Negative Regulation Of Translation Fat Cell Differentiation Adipose Tissue Development
Pathways		Budding and maturation of HIV virion Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Stimuli-sensing channels Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874 33547301) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Aspartate aminotransferase levels ( 34315874 33547301) Childhood body mass index ( 33045005) Diastolic blood pressure ( 30224653) Diisocyanate-induced asthma ( 25918132) Gamma glutamyl transferase levels ( 33339817 29403010) Insomnia (caffeine-induced) ( 22754043) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Manganese levels ( 26025379) Response to amphetamines ( 22952603) Serum alkaline phosphatase levels ( 33339817 33547301)	Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		151 interacting genes: AATF ABL1 ABL2 ACVR1B ACY3 ADAP2 AICDA AKT1 AKT3 AMOT APEX2 ARHGDIA ARRB1 ARRB2 AURKC BBX BMPR1A CACNB1 CAMK1D CDC34 CDK3 CDK5 CEP55 CHLSN CLIC2 CUEDC1 CYBRD1 CYP26B1 DAPK3 DAZAP2 DDX54 DECR2 DMTN DYRK3 EFEMP2 FGF12 FKBP3 FOXO1 GORAB GRIA1 H1-0 HAX1 HNRNPD HSPA5 IFRD2 IKBKB IL6ST KCNAB1 KCNAB2 KCNAB3 KCNB1 KIF3B KIFC3 LAPTM5 MAGEB1 MAP1LC3A MAP2 MAP3K20 MAP3K3 MAP3K5 MAPKAPK3 MARK2 MERTK MINK1 MOB3A MRPL19 NDFIP2 NEAT1 NEIL3 NHP2 NR3C1 NSRP1 NTRK1 NUDT16L1 OGG1 PBX1 PDCD6IP PIP4P2 PRKX PRR16 PRRG1 PRRG2 PSMD4 PTGR3 PYM1 RANBP10 RASL10B RASL11B RHOB RNF11 RNF7 ROBO3 RPL30 RPS6KB2 SCAMP3 SCD SCN5A SCNN1A SCNN1B SCNN1G SENP2 SERPINF1 SGK1 SGK2 SIVA1 SLC7A7 SLC9A3 SMAD2 SMAD3 SMAD7 SNCA SP1 SPAG8 SRMS STAC STK40 TAF1B TARBP2 TBC1D7 TCEAL2 TGFB1I1 TMA16 TRAF3 TRIM41 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2N ULK1 USP7 VDAC2 WBP2 WNK4 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ YY1 ZC3HAV1L ZDHHC3	8 interacting genes: APP JRK MDFI NEDD4L OAS3 OGT POT1 UBE2O
Entrez ID		23327	7866
HPRD ID		05903	04101
Ensembl ID		ENSG00000049759	ENSG00000214706
Uniprot IDs		A0A1B0GVY1 B7Z2P9 B7Z6K0 Q96PU5	Q12894
PDB IDs		2LAJ 2LB2 2LTY 2MPT 2NSQ 2ONI 3JVZ 3JW0 5HPK 6ZBT 6ZC9 7LP1 7LP2 7LP3 7LP4 7LP5 7NMZ
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Kinase Activity ATP Binding Protein Serine/threonine Kinase Activity Protein Modification Process Ubiquitin Protein Ligase Binding Kinase Activity Nucleotide Binding Protein Serine Kinase Activity Protein Phosphorylation Transferase Activity Phosphorylation Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Protein Polyubiquitination Protein Metabolic Process Regulation Of Signaling Protein Ubiquitination Protein Modification By Small Protein Conjugation Cytosol Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Proteolysis Involved In Protein Catabolic Process Response To Nutrient Levels Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cytoplasm Regulation Of Transport Protein Autophosphorylation Cellular Response To Oxygen-containing Compound Protein Domain Specific Binding Regulation Of TORC1 Signaling Regulation Of Protein Ubiquitination Transmembrane Transporter Binding Protein K11-linked Ubiquitination Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication TORC1 Signaling Protein Sequestering Activity Macromolecule Catabolic Process Nucleus Regulation Of TOR Signaling Negative Regulation Of TORC1 Signaling Potassium Channel Regulator Activity Regulation Of Intracellular Signal Transduction MAPK Cascade Negative Regulation Of Signal Transduction	Amyloid-beta Complex Regulation Of Wnt Signaling Pathway Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Synapse Organization Positive Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of Chemokine (C-X-C Motif) Ligand 9 Production Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein Monoubiquitination Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Regulation Of Signal Transduction Regulation Of Purine Nucleotide Metabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Chemokine Production Positive Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Negative Regulation Of Macromolecule Biosynthetic Process Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Negative Regulation Of Biosynthetic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Positive Regulation Of Protein Import Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Low-density Lipoprotein Particle Mediated Signaling Regulation Of Signaling MDA-5 Signaling Pathway Negative Regulation Of IP-10 Production Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production 2'-5'-oligoadenylate Synthetase Activity
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