NEDD4L and MERTK

Number of citations of the paper that reports this interaction (PMID 19953087)
25

Data Source:
BioGRID (enzymatic study)

		NEDD4L	MERTK
Gene Name		neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	MER proto-oncogene, tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome	Photoreceptor Outer Segment Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Rhabdomere
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Potassium Channel Regulator Activity Ligase Activity Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Sodium Channel Inhibitor Activity Ion Channel Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Membrane Depolarization Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Monoubiquitination Sodium Ion Transport Cellular Sodium Ion Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Excretion Response To Salt Stress Response To Metal Ion Gene Expression Positive Regulation Of Sodium Ion Transport Viral Process Protein Ubiquitination Viral Life Cycle Water Homeostasis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Protein Catabolic Process Positive Regulation Of Endocytosis Transmembrane Transport Regulation Of Membrane Repolarization Protein K48-linked Ubiquitination Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Tight Junction Assembly Positive Regulation Of Cation Channel Activity Positive Regulation Of Caveolin-mediated Endocytosis	Natural Killer Cell Differentiation Protein Phosphorylation Phagocytosis Cell Surface Receptor Signaling Pathway Cell-cell Signaling Spermatogenesis Blood Coagulation Peptidyl-tyrosine Phosphorylation Platelet Activation Secretion By Cell Substrate Adhesion-dependent Cell Spreading Apoptotic Cell Clearance Protein Kinase B Signaling Positive Regulation Of Phagocytosis Leukocyte Migration Negative Regulation Of Lymphocyte Activation Retina Development In Camera-type Eye Vagina Development
Pathways		Loss of Function of TGFBR2 in Cancer Antigen processing: Ubiquitination & Proteasome degradation HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer HIV Life Cycle Budding and maturation of HIV virion Ion channel transport Generic Transcription Pathway Stimuli-sensing channels Class I MHC mediated antigen processing & presentation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Late Phase of HIV Life Cycle Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System	Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Insomnia (caffeine-induced) ( 22754043) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Response to amphetamines ( 22952603)	Hepatitis C induced liver fibrosis ( 22841784) Multiple sclerosis ( 21833088)
Protein-Protein Interactions		126 interactors: AATF ABL1 ABL2 ACVR1B ACY3 ADAP2 AICDA AKT3 APEX2 ARHGDIA AURKC BBX BMPR1A BRAF C7orf50 CACNB1 CAMK1D CDC34 CDK3 CDK5 CLIC2 CUEDC1 CYBRD1 CYP26B1 DAPK3 DAZAP2 DDX54 DECR2 DMTN DYRK3 EFEMP2 FGF12 FKBP3 GORAB H1F0 HAX1 HGS IFRD2 IKBKB KCNAB1 KCNAB2 KCNAB3 KCNB1 KIF3B KIFC3 LAPTM5 MAGEB1 MAP2 MAP3K2 MAP3K3 MAP3K5 MAPKAPK3 MARK2 MERTK MINK1 MOB3A MRPL19 NDFIP2 NHP2 NR3C1 NSRP1 NTRK1 NUDT16L1 PBX1 PRKX PRR16 PRRG1 PSMD4 RANBP10 RASL10B RASL11B RNF11 RNF7 ROBO3 RPL30 RPS6KB2 SCAMP3 SCD SCN5A SCNN1A SCNN1B SCNN1G SENP2 SERPINF1 SGK1 SGK2 SIVA1 SLC7A7 SMAD2 SMAD3 SMAD7 SNCA SPAG8 SRMS STAC STK40 TAF1B TARBP2 TBC1D7 TCEAL2 TGFB1I1 TMA16 TMEM55A TRIM41 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2J2 UBE2K UBE2L3 UBE2N VDAC2 WIBG WNK1 WNK4 YWHAG YWHAZ YY1 ZADH2 ZAK ZC3HAV1L ZDHHC3	8 interactors: BMPR2 GAS6 GRB2 IKBKG LMO4 NEDD4L TNK2 VAV1
Entrez ID		23327	10461
HPRD ID		05903	05269
Ensembl ID		ENSG00000049759	ENSG00000153208
Uniprot IDs		B7Z2P9 B7Z6K0 F5H602 Q96PU5	E9PHX8 Q12866
PDB IDs		2LAJ 2LB2 2LTY 2NSQ 2ONI 3JVZ 3JW0	2DBJ 2P0C 3BPR 3BRB 3TCP
Enriched GO Terms of Interacting Partners?		Cellular Protein Modification Process Protein Phosphorylation Intracellular Signal Transduction Response To Stimulus Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Signaling Regulation Of Signal Transduction Cell Communication Regulation Of Signaling Positive Regulation Of Metabolic Process Protein Polyubiquitination Response To Organic Substance Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Signal Transduction Response To Growth Factor Cellular Response To Organic Substance Protein K48-linked Ubiquitination Regulation Of Cellular Component Organization Enzyme Linked Receptor Protein Signaling Pathway Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Protein Phosphorylation Protein Autophosphorylation Phosphate-containing Compound Metabolic Process Signal Transduction Positive Regulation Of Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Transport Cellular Response To Growth Factor Stimulus Cellular Metabolic Process Immune System Process Protein Ubiquitination Regulation Of Cellular Process Positive Regulation Of Protein Ubiquitination Cell Death Positive Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Death Regulation Of Cellular Component Movement	Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Systemic Arterial Blood Pressure Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Cellular Component Organization Response To Stress Regulation Of Cell Activation Immune System Process Positive Regulation Of Protein Metabolic Process Viral Process Regulation Of Blood Pressure Negative Regulation Of Systemic Arterial Blood Pressure Cellular Response To Growth Factor Stimulus Immune Response Regulation Of Phosphorylation Regulation Of Endocytosis Response To Growth Factor Platelet Activation Endocytosis Positive Regulation Of Cellular Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorus Metabolic Process Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Phagocytosis Fc Receptor Signaling Pathway Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Migration Regulation Of Metabolic Process Positive Regulation Of Cell Activation Positive Regulation Of Phosphorylation Regulation Of Signaling Negative Regulation Of Blood Pressure Regulation Of Nitrogen Compound Metabolic Process Blood Circulation Response To External Stimulus Positive Regulation Of Immune System Process Cell Motility Positive Regulation Of Protein Modification Process Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Regulation Of Lymphocyte Activation Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Signaling
Tagcloud ?		2cl antihypertensive cotransporter defective demonstrating emerging enac exchanger highlight hypertension interactor interesting liddle ligase makes na ncc nephron nhe3 nkcc2 originally progress salt sensitive thiazide transporters ubiquitin ubiquitylates	apoptotic autoimmunity c1q clearance dehydrogenases e8 ebpbeta efferocytosis engulfed enhancement enhancing glucocorticoid glucocorticoids lxr lxrs macrophages mfg partly phagocytic phagocytosis ppardelta raldh1 raralpha retinaldehyde retinoids rxralpha seem sensing ucp2
Tagcloud (Difference) ?		2cl antihypertensive cotransporter defective demonstrating emerging enac exchanger highlight hypertension interactor interesting liddle ligase makes na ncc nephron nhe3 nkcc2 originally progress salt sensitive thiazide transporters ubiquitin ubiquitylates	apoptotic autoimmunity c1q clearance dehydrogenases e8 ebpbeta efferocytosis engulfed enhancement enhancing glucocorticoid glucocorticoids lxr lxrs macrophages mfg partly phagocytic phagocytosis ppardelta raldh1 raralpha retinaldehyde retinoids rxralpha seem sensing ucp2
Tagcloud (Intersection) ?