NEDD4L and AKT3

Number of citations of the paper that reports this interaction (PubMedID 19953087)
60

Data Source:
BioGRID (enzymatic study)

		NEDD4L	AKT3
Description		NEDD4 like E3 ubiquitin protein ligase	AKT serine/threonine kinase 3
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Multivesicular Body Golgi Apparatus Cytosol Plasma Membrane Apical Plasma Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cilium Membrane Ciliary Basal Body
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Sodium Channel Inhibitor Activity Transmembrane Transporter Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of Membrane Depolarization Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Monoatomic Ion Transport Neuromuscular Junction Development Protein Ubiquitination Cell Differentiation Neuron Projection Development Receptor Internalization Regulation Of Protein Stability Receptor Catabolic Process Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Regulation Of Membrane Repolarization Regulation Of Biological Quality Protein K48-linked Ubiquitination Ventricular Cardiac Muscle Cell Action Potential Sodium Ion Import Across Plasma Membrane Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Dendrite Extension Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Caveolin-mediated Endocytosis	Positive Regulation Of Endothelial Cell Proliferation Protein Phosphorylation Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of TOR Signaling Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Cell Size Brain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Artery Morphogenesis Negative Regulation Of Cellular Senescence
Pathways		Budding and maturation of HIV virion Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Stimuli-sensing channels Antigen processing: Ubiquitination & Proteasome degradation	Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network AKT-mediated inactivation of FOXO1A CD28 dependent PI3K/Akt signaling Co-inhibition by CTLA4 G beta:gamma signalling through PI3Kgamma VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling KEAP1-NFE2L2 pathway SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874 33547301) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Aspartate aminotransferase levels ( 34315874 33547301) Childhood body mass index ( 33045005) Diastolic blood pressure ( 30224653) Diisocyanate-induced asthma ( 25918132) Gamma glutamyl transferase levels ( 33339817 29403010) Insomnia (caffeine-induced) ( 22754043) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Manganese levels ( 26025379) Response to amphetamines ( 22952603) Serum alkaline phosphatase levels ( 33339817 33547301)	Adult body size ( 32376654) Adult diffuse glioma (IDH mutation) ( 32386320) Adventurousness ( 30643258) Antisaccade task score ( 31596458) Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diabetic retinopathy ( 21441570) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Educational attainment ( 25201988) ghrelin levels ( 33852427) Height ( 28552196) Menarche (age at onset) ( 23599027) Monocyte count ( 32888494) Non-glioblastoma glioma ( 28346443) Platelet distribution width ( 32888494) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) RR interval (heart rate) ( 20031603) Schizophrenia ( 25056061 23974872 28991256 30285260 29483656) Self-reported risk-taking behaviour ( 30181555) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		151 interacting genes: AATF ABL1 ABL2 ACVR1B ACY3 ADAP2 AICDA AKT1 AKT3 AMOT APEX2 ARHGDIA ARRB1 ARRB2 AURKC BBX BMPR1A CACNB1 CAMK1D CDC34 CDK3 CDK5 CEP55 CHLSN CLIC2 CUEDC1 CYBRD1 CYP26B1 DAPK3 DAZAP2 DDX54 DECR2 DMTN DYRK3 EFEMP2 FGF12 FKBP3 FOXO1 GORAB GRIA1 H1-0 HAX1 HNRNPD HSPA5 IFRD2 IKBKB IL6ST KCNAB1 KCNAB2 KCNAB3 KCNB1 KIF3B KIFC3 LAPTM5 MAGEB1 MAP1LC3A MAP2 MAP3K20 MAP3K3 MAP3K5 MAPKAPK3 MARK2 MERTK MINK1 MOB3A MRPL19 NDFIP2 NEAT1 NEIL3 NHP2 NR3C1 NSRP1 NTRK1 NUDT16L1 OGG1 PBX1 PDCD6IP PIP4P2 PRKX PRR16 PRRG1 PRRG2 PSMD4 PTGR3 PYM1 RANBP10 RASL10B RASL11B RHOB RNF11 RNF7 ROBO3 RPL30 RPS6KB2 SCAMP3 SCD SCN5A SCNN1A SCNN1B SCNN1G SENP2 SERPINF1 SGK1 SGK2 SIVA1 SLC7A7 SLC9A3 SMAD2 SMAD3 SMAD7 SNCA SP1 SPAG8 SRMS STAC STK40 TAF1B TARBP2 TBC1D7 TCEAL2 TGFB1I1 TMA16 TRAF3 TRIM41 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2N ULK1 USP7 VDAC2 WBP2 WNK4 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ YY1 ZC3HAV1L ZDHHC3	12 interacting genes: CRYAA FBXO7 GSK3B IWS1 NEDD4 NEDD4L PDPK1 PPP2CA PRKCD PRKCZ TCL1A TSC2
Entrez ID		23327	10000
HPRD ID		05903	06441
Ensembl ID		ENSG00000049759	ENSG00000117020
Uniprot IDs		A0A1B0GVY1 B7Z2P9 B7Z6K0 Q96PU5	A0A5F9ZHU3 A0A7P0TB32 A0A7P0TBJ6 Q9Y243
PDB IDs		2LAJ 2LB2 2LTY 2MPT 2NSQ 2ONI 3JVZ 3JW0 5HPK 6ZBT 6ZC9 7LP1 7LP2 7LP3 7LP4 7LP5 7NMZ	2X18 8ZXW
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Kinase Activity ATP Binding Protein Serine/threonine Kinase Activity Protein Modification Process Ubiquitin Protein Ligase Binding Kinase Activity Nucleotide Binding Protein Serine Kinase Activity Protein Phosphorylation Transferase Activity Phosphorylation Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Protein Polyubiquitination Protein Metabolic Process Regulation Of Signaling Protein Ubiquitination Protein Modification By Small Protein Conjugation Cytosol Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Proteolysis Involved In Protein Catabolic Process Response To Nutrient Levels Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cytoplasm Regulation Of Transport Protein Autophosphorylation Cellular Response To Oxygen-containing Compound Protein Domain Specific Binding Regulation Of TORC1 Signaling Regulation Of Protein Ubiquitination Transmembrane Transporter Binding Protein K11-linked Ubiquitination Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication TORC1 Signaling Protein Sequestering Activity Macromolecule Catabolic Process Nucleus Regulation Of TOR Signaling Negative Regulation Of TORC1 Signaling Potassium Channel Regulator Activity Regulation Of Intracellular Signal Transduction MAPK Cascade Negative Regulation Of Signal Transduction	Regulation Of Transport Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Catabolic Process Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Protein Kinase Binding Regulation Of Intracellular Transport Protein Modification Process Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Localization Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Cytoplasm Regulation Of Protein Stability Sodium Channel Inhibitor Activity Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Dendrite Morphogenesis Developmental Process Negative Regulation Of Transport Negative Regulation Of Cation Transmembrane Transport Regulation Of Membrane Potential Regulation Of Neuron Projection Development Potassium Channel Inhibitor Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Nucleus Regulation Of Potassium Ion Export Across Plasma Membrane Cytosol Protein Metabolic Process Insulin Receptor Substrate Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Sodium Ion Transport Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Apoptotic Process Establishment Of Cell Polarity Regulation Of Monoatomic Cation Transmembrane Transport Vascular Endothelial Cell Response To Fluid Shear Stress
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?