NEDD4L and AKT3

Number of citations of the paper that reports this interaction (PMID 19953087)
25

Data Source:
BioGRID (enzymatic study)

		NEDD4L	AKT3
Gene Name		neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	v-akt murine thymoma viral oncogene homolog 3
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Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Potassium Channel Regulator Activity Ligase Activity Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Sodium Channel Inhibitor Activity Ion Channel Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Membrane Depolarization Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Monoubiquitination Sodium Ion Transport Cellular Sodium Ion Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Excretion Response To Salt Stress Response To Metal Ion Gene Expression Positive Regulation Of Sodium Ion Transport Viral Process Protein Ubiquitination Viral Life Cycle Water Homeostasis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Protein Catabolic Process Positive Regulation Of Endocytosis Transmembrane Transport Regulation Of Membrane Repolarization Protein K48-linked Ubiquitination Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Tight Junction Assembly Positive Regulation Of Cation Channel Activity Positive Regulation Of Caveolin-mediated Endocytosis	Mitochondrial Genome Maintenance Protein Phosphorylation Signal Transduction
Pathways		Loss of Function of TGFBR2 in Cancer Antigen processing: Ubiquitination & Proteasome degradation HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer HIV Life Cycle Budding and maturation of HIV virion Ion channel transport Generic Transcription Pathway Stimuli-sensing channels Class I MHC mediated antigen processing & presentation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Late Phase of HIV Life Cycle Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease Activation of BH3-only proteins Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Regulation of beta-cell development PI3K/AKT activation PI-3K cascade Signaling by PDGF Downregulation of ERBB2:ERBB3 signaling DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Activation of BAD and translocation to mitochondria Signaling by EGFR GPCR downstream signaling Signaling by VEGF AKT phosphorylates targets in the nucleus Downstream signal transduction Regulation of gene expression in beta cells Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Adaptive Immune System Costimulation by the CD28 family PIP3 activates AKT signaling VEGFA-VEGFR2 Pathway G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Downstream signaling of activated FGFR VEGFR2 mediated vascular permeability Programmed Cell Death Intrinsic Pathway for Apoptosis Innate Immune System Signalling by NGF CTLA4 inhibitory signaling AKT-mediated inactivation of FOXO1A Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Negative regulation of the PI3K/AKT network Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR GPVI-mediated activation cascade
Drugs
Diseases
GWAS		Insomnia (caffeine-induced) ( 22754043) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Response to amphetamines ( 22952603)	Diabetic retinopathy ( 21441570) Menarche (age at onset) ( 23599027) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) RR interval (heart rate) ( 20031603)
Protein-Protein Interactions		126 interactors: AATF ABL1 ABL2 ACVR1B ACY3 ADAP2 AICDA AKT3 APEX2 ARHGDIA AURKC BBX BMPR1A BRAF C7orf50 CACNB1 CAMK1D CDC34 CDK3 CDK5 CLIC2 CUEDC1 CYBRD1 CYP26B1 DAPK3 DAZAP2 DDX54 DECR2 DMTN DYRK3 EFEMP2 FGF12 FKBP3 GORAB H1F0 HAX1 HGS IFRD2 IKBKB KCNAB1 KCNAB2 KCNAB3 KCNB1 KIF3B KIFC3 LAPTM5 MAGEB1 MAP2 MAP3K2 MAP3K3 MAP3K5 MAPKAPK3 MARK2 MERTK MINK1 MOB3A MRPL19 NDFIP2 NHP2 NR3C1 NSRP1 NTRK1 NUDT16L1 PBX1 PRKX PRR16 PRRG1 PSMD4 RANBP10 RASL10B RASL11B RNF11 RNF7 ROBO3 RPL30 RPS6KB2 SCAMP3 SCD SCN5A SCNN1A SCNN1B SCNN1G SENP2 SERPINF1 SGK1 SGK2 SIVA1 SLC7A7 SMAD2 SMAD3 SMAD7 SNCA SPAG8 SRMS STAC STK40 TAF1B TARBP2 TBC1D7 TCEAL2 TGFB1I1 TMA16 TMEM55A TRIM41 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2J2 UBE2K UBE2L3 UBE2N VDAC2 WIBG WNK1 WNK4 YWHAG YWHAZ YY1 ZADH2 ZAK ZC3HAV1L ZDHHC3	8 interactors: GSK3B NEDD4 NEDD4L PDPK1 PRKCD PRKCZ TCL1A TSC2
Entrez ID		23327	10000
HPRD ID		05903	06441
Ensembl ID		ENSG00000049759	ENSG00000117020
Uniprot IDs		B7Z2P9 B7Z6K0 F5H602 Q96PU5	Q9Y243
PDB IDs		2LAJ 2LB2 2LTY 2NSQ 2ONI 3JVZ 3JW0	2X18
Enriched GO Terms of Interacting Partners?		Cellular Protein Modification Process Protein Phosphorylation Intracellular Signal Transduction Response To Stimulus Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Signaling Regulation Of Signal Transduction Cell Communication Regulation Of Signaling Positive Regulation Of Metabolic Process Protein Polyubiquitination Response To Organic Substance Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Signal Transduction Response To Growth Factor Cellular Response To Organic Substance Protein K48-linked Ubiquitination Regulation Of Cellular Component Organization Enzyme Linked Receptor Protein Signaling Pathway Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Protein Phosphorylation Protein Autophosphorylation Phosphate-containing Compound Metabolic Process Signal Transduction Positive Regulation Of Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Transport Cellular Response To Growth Factor Stimulus Cellular Metabolic Process Immune System Process Protein Ubiquitination Regulation Of Cellular Process Positive Regulation Of Protein Ubiquitination Cell Death Positive Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Death Regulation Of Cellular Component Movement	Negative Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Negative Regulation Of Signaling Response To Growth Factor Negative Regulation Of Protein Phosphorylation Positive Regulation Of Transport Negative Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cellular Component Organization Negative Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Phospholipase Activity Regulation Of Protein Kinase Activity Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Transferase Activity Regulation Of Phospholipase Activity Negative Regulation Of Catalytic Activity Positive Regulation Of Lipase Activity Regulation Of Kinase Activity Regulation Of Signal Transduction Negative Regulation Of MAP Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Signaling Negative Regulation Of Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Negative Regulation Of Sodium Ion Transport Positive Regulation Of Hydrolase Activity Regulation Of Cellular Localization Regulation Of Protein Phosphorylation
Tagcloud ?		2cl antihypertensive cotransporter defective demonstrating emerging enac exchanger highlight hypertension interactor interesting liddle ligase makes na ncc nephron nhe3 nkcc2 originally progress salt sensitive thiazide transporters ubiquitin ubiquitylates	aberrant blot candidate downregulated dysregulation effectively exact forced hcc hepatocellular invasion inversely luciferase metastasis micrornas migration mir144 mirnas numerous overexpression remains reversed suppressed suppressive suppressor targeting tissues transfected unclear
Tagcloud (Difference) ?		2cl antihypertensive cotransporter defective demonstrating emerging enac exchanger highlight hypertension interactor interesting liddle ligase makes na ncc nephron nhe3 nkcc2 originally progress salt sensitive thiazide transporters ubiquitin ubiquitylates	aberrant blot candidate downregulated dysregulation effectively exact forced hcc hepatocellular invasion inversely luciferase metastasis micrornas migration mir144 mirnas numerous overexpression remains reversed suppressed suppressive suppressor targeting tissues transfected unclear
Tagcloud (Intersection) ?