NEDD4L and SP1

Number of citations of the paper that reports this interaction (PubMedID 32724456)
40

Data Source:
BioGRID (pull down)

		NEDD4L	SP1
Description		NEDD4 like E3 ubiquitin protein ligase	Sp1 transcription factor
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Multivesicular Body Golgi Apparatus Cytosol Plasma Membrane Apical Plasma Membrane Extracellular Exosome	Chromatin Euchromatin Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex Protein-DNA Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Sodium Channel Inhibitor Activity Transmembrane Transporter Binding Ubiquitin Protein Ligase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Acetyltransferase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding Molecular Adaptor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Membrane Depolarization Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Monoatomic Ion Transport Neuromuscular Junction Development Protein Ubiquitination Cell Differentiation Neuron Projection Development Receptor Internalization Regulation Of Protein Stability Receptor Catabolic Process Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Regulation Of Membrane Repolarization Regulation Of Biological Quality Protein K48-linked Ubiquitination Ventricular Cardiac Muscle Cell Action Potential Sodium Ion Import Across Plasma Membrane Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Dendrite Extension Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Caveolin-mediated Endocytosis	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Cellular Response To Insulin Stimulus Response To Hydroperoxide Cellular Response To Zinc Ion Starvation Positive Regulation Of Blood Vessel Endothelial Cell Migration Host-mediated Activation Of Viral Transcription Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Cellular Response To Estrogen Stimulus Positive Regulation Of Amyloid-beta Formation Cellular Response To Wortmannin Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Budding and maturation of HIV virion Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Stimuli-sensing channels Antigen processing: Ubiquitination & Proteasome degradation	PPARA activates gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Activation of gene expression by SREBF (SREBP) Oncogene Induced Senescence RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes Estrogen-dependent gene expression SARS-CoV-1 targets host intracellular signalling and regulatory pathways Regulation of CDH11 gene transcription Regulation of CDH11 gene transcription Positive Regulation of CDH1 Gene Transcription NFE2L2 regulating tumorigenic genes TGFBR3 expression
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874 33547301) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Aspartate aminotransferase levels ( 34315874 33547301) Childhood body mass index ( 33045005) Diastolic blood pressure ( 30224653) Diisocyanate-induced asthma ( 25918132) Gamma glutamyl transferase levels ( 33339817 29403010) Insomnia (caffeine-induced) ( 22754043) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Manganese levels ( 26025379) Response to amphetamines ( 22952603) Serum alkaline phosphatase levels ( 33339817 33547301)	Apolipoprotein B levels ( 32203549) High light scatter reticulocyte count ( 32888494) Hypospadias (moderate to severe) ( 31856834) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 27863252) Parkinsonism in frontotemporal lobe dementia ( 29724592) Percentage gas trapping ( 26030696) Progressive supranuclear palsy ( 30089514) Red blood cell count ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		151 interacting genes: AATF ABL1 ABL2 ACVR1B ACY3 ADAP2 AICDA AKT1 AKT3 AMOT APEX2 ARHGDIA ARRB1 ARRB2 AURKC BBX BMPR1A CACNB1 CAMK1D CDC34 CDK3 CDK5 CEP55 CHLSN CLIC2 CUEDC1 CYBRD1 CYP26B1 DAPK3 DAZAP2 DDX54 DECR2 DMTN DYRK3 EFEMP2 FGF12 FKBP3 FOXO1 GORAB GRIA1 H1-0 HAX1 HNRNPD HSPA5 IFRD2 IKBKB IL6ST KCNAB1 KCNAB2 KCNAB3 KCNB1 KIF3B KIFC3 LAPTM5 MAGEB1 MAP1LC3A MAP2 MAP3K20 MAP3K3 MAP3K5 MAPKAPK3 MARK2 MERTK MINK1 MOB3A MRPL19 NDFIP2 NEAT1 NEIL3 NHP2 NR3C1 NSRP1 NTRK1 NUDT16L1 OGG1 PBX1 PDCD6IP PIP4P2 PRKX PRR16 PRRG1 PRRG2 PSMD4 PTGR3 PYM1 RANBP10 RASL10B RASL11B RHOB RNF11 RNF7 ROBO3 RPL30 RPS6KB2 SCAMP3 SCD SCN5A SCNN1A SCNN1B SCNN1G SENP2 SERPINF1 SGK1 SGK2 SIVA1 SLC7A7 SLC9A3 SMAD2 SMAD3 SMAD7 SNCA SP1 SPAG8 SRMS STAC STK40 TAF1B TARBP2 TBC1D7 TCEAL2 TGFB1I1 TMA16 TRAF3 TRIM41 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2N ULK1 USP7 VDAC2 WBP2 WNK4 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ YY1 ZC3HAV1L ZDHHC3	149 interacting genes: AATF AHR AKT1 AR ARHGAP21 ARNT ATF7IP ATF7IP2 BCL11B BCL6 BCOR BRCA1 CASP3 CASP6 CASP7 CBX5 CCNA1 CCNA2 CCND1 CD2 CDK1 CDK2 CEBPB CSNK2A1 CTCFL CTNNB1 DROSHA E2F1 E2F2 E2F3 EGR1 ELF1 EP300 ESR1 ESR2 ESRRA ESRRB ESRRG ETS1 GABPA GATA1 GATA3 GATA4 HBZ HCFC1 HDAC1 HDAC2 HIF1A HINT1 HLTF HMGA1 HNF4A HOXC11 HSPA8 HTT IL1B JUN KAT2B KIF1A KLF10 KLF4 KLF6 LDB1 LINC00955 LMO2 MAP1LC3A MAPK1 MAPK3 MAPK8 MBD1 MEF2C MEF2D MIER1 MIS18BP1 MSX1 MTREX MYC MYCN MYOD1 MYOG NAP1L1 NCOR1 NCOR2 NEDD4L NFKB1 NFKB2 NFYA NFYB NFYC NKX3-1 NOS3 NPM1 NR2F1 NR5A1 NUP62 OGT PARP1 PER3 PML POGZ POU2F1 PPIG PPP1R13L PRKCZ PRKDC PSIP1 PSMC5 PURA RARA RB1 RBBP4 RBL1 REL RELA RMP64 RNF4 RORA RXRA SENP6 SF3A1 SHC1 SMAD2 SMAD3 SMAD4 SMARCC1 SMARCC2 SOX10 SOX8 SP3 SP4 SREBF1 SREBF2 SRF SUB1 SUMO2 TAF4 TAL1 TBP TLX3 TP53 TP73 TPI1 VEGFA VHL YY1 ZBTB16 ZBTB2 ZBTB5 ZBTB7A
Entrez ID		23327	6667
HPRD ID		05903	01796
Ensembl ID		ENSG00000049759	ENSG00000185591
Uniprot IDs		A0A1B0GVY1 B7Z2P9 B7Z6K0 Q96PU5	P08047
PDB IDs		2LAJ 2LB2 2LTY 2MPT 2NSQ 2ONI 3JVZ 3JW0 5HPK 6ZBT 6ZC9 7LP1 7LP2 7LP3 7LP4 7LP5 7NMZ	1SP1 1SP2 1VA1 1VA2 1VA3 6PV0 6PV1 6PV2 6PV3 6UCO 6UCP
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Kinase Activity ATP Binding Protein Serine/threonine Kinase Activity Protein Modification Process Ubiquitin Protein Ligase Binding Kinase Activity Nucleotide Binding Protein Serine Kinase Activity Protein Phosphorylation Transferase Activity Phosphorylation Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Protein Polyubiquitination Protein Metabolic Process Regulation Of Signaling Protein Ubiquitination Protein Modification By Small Protein Conjugation Cytosol Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Proteolysis Involved In Protein Catabolic Process Response To Nutrient Levels Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cytoplasm Regulation Of Transport Protein Autophosphorylation Cellular Response To Oxygen-containing Compound Protein Domain Specific Binding Regulation Of TORC1 Signaling Regulation Of Protein Ubiquitination Transmembrane Transporter Binding Protein K11-linked Ubiquitination Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication TORC1 Signaling Protein Sequestering Activity Macromolecule Catabolic Process Nucleus Regulation Of TOR Signaling Negative Regulation Of TORC1 Signaling Potassium Channel Regulator Activity Regulation Of Intracellular Signal Transduction MAPK Cascade Negative Regulation Of Signal Transduction	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleoplasm Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Negative Regulation Of Metabolic Process DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Cis-regulatory Region Binding Sequence-specific Double-stranded DNA Binding Regulation Of MiRNA Metabolic Process DNA-templated Transcription Regulation Of MiRNA Transcription Regulation Of Developmental Process Chromatin Binding Regulation Of Multicellular Organismal Process Regulation Of Cell Population Proliferation Cis-regulatory Region Sequence-specific DNA Binding
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