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NEDD4L and UBE2D2
Number of citations of the paper that reports this interaction (PubMedID
37345264
)
60
Data Source:
BioGRID
(pull down)
NEDD4L
UBE2D2
Description
NEDD4 like E3 ubiquitin protein ligase
ubiquitin conjugating enzyme E2 D2
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Endosome
Multivesicular Body
Golgi Apparatus
Cytosol
Plasma Membrane
Apical Plasma Membrane
Extracellular Exosome
Nucleus
Nucleoplasm
Cytosol
Protein-containing Complex
Extracellular Exosome
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Transferase Activity
Sodium Channel Regulator Activity
Potassium Channel Inhibitor Activity
Sodium Channel Inhibitor Activity
Transmembrane Transporter Binding
Ubiquitin Protein Ligase Activity
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Regulation Of Membrane Depolarization
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Monoatomic Ion Transport
Neuromuscular Junction Development
Protein Ubiquitination
Cell Differentiation
Neuron Projection Development
Receptor Internalization
Regulation Of Protein Stability
Receptor Catabolic Process
Monoatomic Ion Transmembrane Transport
Regulation Of Membrane Potential
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Regulation Of Dendrite Morphogenesis
Regulation Of Synapse Organization
Regulation Of Membrane Repolarization
Regulation Of Biological Quality
Protein K48-linked Ubiquitination
Ventricular Cardiac Muscle Cell Action Potential
Sodium Ion Import Across Plasma Membrane
Negative Regulation Of Potassium Ion Transmembrane Transport
Regulation Of Sodium Ion Transmembrane Transport
Negative Regulation Of Sodium Ion Transmembrane Transport
Negative Regulation Of Potassium Ion Export Across Plasma Membrane
Negative Regulation Of Sodium Ion Import Across Plasma Membrane
Positive Regulation Of Dendrite Extension
Negative Regulation Of Protein Localization To Cell Surface
Positive Regulation Of Caveolin-mediated Endocytosis
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Protein Modification Process
Protein Autoubiquitination
Protein K48-linked Ubiquitination
Pathways
Budding and maturation of HIV virion
Downregulation of TGF-beta receptor signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Stimuli-sensing channels
Antigen processing: Ubiquitination & Proteasome degradation
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
TICAM1, RIP1-mediated IKK complex recruitment
Downstream TCR signaling
FCERI mediated NF-kB activation
PINK1-PRKN Mediated Mitophagy
Regulation of TNFR1 signaling
CLEC7A (Dectin-1) signaling
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
Negative regulators of DDX58/IFIH1 signaling
IKK complex recruitment mediated by RIP1
Inactivation of CSF3 (G-CSF) signaling
Antigen processing: Ubiquitination & Proteasome degradation
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
(R,R)-2,3-Butanediol
Diseases
GWAS
Alanine aminotransferase levels (
34315874
33547301
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Aspartate aminotransferase levels (
34315874
33547301
)
Childhood body mass index (
33045005
)
Diastolic blood pressure (
30224653
)
Diisocyanate-induced asthma (
25918132
)
Gamma glutamyl transferase levels (
33339817
29403010
)
Insomnia (caffeine-induced) (
22754043
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Liver enzyme levels (gamma-glutamyl transferase) (
22001757
33972514
)
Manganese levels (
26025379
)
Response to amphetamines (
22952603
)
Serum alkaline phosphatase levels (
33339817
33547301
)
Alzheimer's disease (late onset) (
30820047
)
Body mass index (
26426971
)
Immune reponse to smallpox (secreted IFN-alpha) (
22610502
)
Leukocyte telomere length (
32109421
)
Interacting Genes
151 interacting genes:
AATF
ABL1
ABL2
ACVR1B
ACY3
ADAP2
AICDA
AKT1
AKT3
AMOT
APEX2
ARHGDIA
ARRB1
ARRB2
AURKC
BBX
BMPR1A
CACNB1
CAMK1D
CDC34
CDK3
CDK5
CEP55
CHLSN
CLIC2
CUEDC1
CYBRD1
CYP26B1
DAPK3
DAZAP2
DDX54
DECR2
DMTN
DYRK3
EFEMP2
FGF12
FKBP3
FOXO1
GORAB
GRIA1
H1-0
HAX1
HNRNPD
HSPA5
IFRD2
IKBKB
IL6ST
KCNAB1
KCNAB2
KCNAB3
KCNB1
KIF3B
KIFC3
LAPTM5
MAGEB1
MAP1LC3A
MAP2
MAP3K20
MAP3K3
MAP3K5
MAPKAPK3
MARK2
MERTK
MINK1
MOB3A
MRPL19
NDFIP2
NEAT1
NEIL3
NHP2
NR3C1
NSRP1
NTRK1
NUDT16L1
OGG1
PBX1
PDCD6IP
PIP4P2
PRKX
PRR16
PRRG1
PRRG2
PSMD4
PTGR3
PYM1
RANBP10
RASL10B
RASL11B
RHOB
RNF11
RNF7
ROBO3
RPL30
RPS6KB2
SCAMP3
SCD
SCN5A
SCNN1A
SCNN1B
SCNN1G
SENP2
SERPINF1
SGK1
SGK2
SIVA1
SLC7A7
SLC9A3
SMAD2
SMAD3
SMAD7
SNCA
SP1
SPAG8
SRMS
STAC
STK40
TAF1B
TARBP2
TBC1D7
TCEAL2
TGFB1I1
TMA16
TRAF3
TRIM41
UBAC1
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2J2
UBE2K
UBE2L3
UBE2L6
UBE2N
ULK1
USP7
VDAC2
WBP2
WNK4
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
YY1
ZC3HAV1L
ZDHHC3
244 interacting genes:
AMFR
ANAPC11
ANAPC2
AREL1
ARIH2
ARRDC3
BARD1
BFAR
BIRC2
BIRC3
BIRC7
BIRC8
BMI1
BRAP
BRCA1
BTRC
CADPS2
CBL
CBLB
CBLC
CCNB1
CDKN1B
CHFR
CNOT4
COP1
CUEDC1
CUL3
DCAF1
DTX1
DTX2
DTX3
DTX3L
DZIP3
EPS15
F12
FBXL3
FBXO2
FBXO4
FBXO7
FBXW2
HACE1
HECTD1
HECTD3
HECTD4
HECW1
HECW2
HERC1
HERC2
HERC4
HUWE1
ITCH
KAT2B
KCMF1
LNX1
LNX2
LRSAM1
LTN1
MAP3K1
MAPT
MARCHF3
MARCHF5
MARCHF6
MARCHF7
MDM2
MDM4
MEX3A
MEX3C
MGRN1
MIB1
MIB2
MID1
MID2
MKRN2
MKRN3
MUL1
MYCBP2
MYLIP
NAT10
NBR1
NEDD4
NEDD4L
NFKB1
NFKBIA
NPR1
NSMCE1
OBI1
OTUB1
PDZRN3
PELI1
PHF7
PHRF1
PJA1
PJA2
PMAIP1
POLL
POLM
PRKN
QSOX1
RAD18
RAF1
RAG1
RBCK1
RBX1
RC3H1
RC3H2
RCHY1
RELA
RFFL
RFWD3
RIGI
RING1
RLIM
RMND5B
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF123
RNF126
RNF13
RNF130
RNF135
RNF138
RNF14
RNF144A
RNF146
RNF149
RNF150
RNF151
RNF166
RNF167
RNF168
RNF170
RNF181
RNF185
RNF186
RNF19A
RNF19B
RNF2
RNF20
RNF213
RNF216
RNF220
RNF224
RNF25
RNF26
RNF31
RNF34
RNF38
RNF4
RNF40
RNF43
RNF5
RNF7
RNF8
RSPRY1
RTF2
SIAH1
SIAH2
SMURF1
SMURF2
SNCA
SOCS6
SPOP
STAM2
STK11
STUB1
SYVN1
TOPORS
TP53
TRAF2
TRAF6
TRAF7
TRAIP
TRIM10
TRIM11
TRIM13
TRIM17
TRIM2
TRIM21
TRIM23
TRIM25
TRIM26
TRIM27
TRIM28
TRIM3
TRIM31
TRIM32
TRIM33
TRIM34
TRIM35
TRIM36
TRIM37
TRIM38
TRIM39
TRIM41
TRIM43
TRIM45
TRIM46
TRIM47
TRIM5
TRIM50
TRIM54
TRIM55
TRIM62
TRIM63
TRIM65
TRIM7
TRIM8
TRIP12
TTC3
UBA1
UBA3
UBA5
UBA6
UBASH3B
UBD
UBE3A
UBE3C
UBE4A
UBE4B
UBOX5
UBR1
UBR2
UBR3
UBR4
UBR5
UFM1
UHRF1
UHRF2
UVSSA
VHL
VPS11
VPS18
WSB1
WWP1
WWP2
XIAP
ZNRF1
ZNRF2
ZNRF4
Entrez ID
23327
7322
HPRD ID
05903
04268
Ensembl ID
ENSG00000049759
ENSG00000131508
Uniprot IDs
A0A1B0GVY1
B7Z2P9
B7Z6K0
Q96PU5
P62837
PDB IDs
2LAJ
2LB2
2LTY
2MPT
2NSQ
2ONI
3JVZ
3JW0
5HPK
6ZBT
6ZC9
7LP1
7LP2
7LP3
7LP4
7LP5
7NMZ
1UR6
1W4U
2CLW
2ESK
2ESO
2ESP
2ESQ
3A33
3JVZ
3JW0
3L1Y
3TGD
3ZNI
4A49
4A4B
4A4C
4AUQ
4DDG
4DDI
4LDT
4V3K
4V3L
4WZ3
5D0K
5D0M
5D1K
5D1L
5D1M
5EDV
5MNJ
5ULF
5ULH
5ULK
5VZW
5ZBU
6HPR
6M2C
6SQO
6SQR
6SQS
6TTU
6W7Z
6W9D
7AI0
7AI1
7BOL
7R71
8B3I
8GBQ
8GCB
8GRM
8JWJ
8JWU
8V0D
8VK8
8VK9
Enriched GO Terms of Interacting Partners
?
Ubiquitin Conjugating Enzyme Activity
Protein Kinase Activity
ATP Binding
Protein Serine/threonine Kinase Activity
Protein Modification Process
Ubiquitin Protein Ligase Binding
Kinase Activity
Nucleotide Binding
Protein Serine Kinase Activity
Protein Phosphorylation
Transferase Activity
Phosphorylation
Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Cell Communication
Protein Polyubiquitination
Protein Metabolic Process
Regulation Of Signaling
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cytosol
Macromolecule Metabolic Process
Modification-dependent Protein Catabolic Process
Cellular Response To Nutrient Levels
Proteolysis Involved In Protein Catabolic Process
Response To Nutrient Levels
Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Cytoplasm
Regulation Of Transport
Protein Autophosphorylation
Cellular Response To Oxygen-containing Compound
Protein Domain Specific Binding
Regulation Of TORC1 Signaling
Regulation Of Protein Ubiquitination
Transmembrane Transporter Binding
Protein K11-linked Ubiquitination
Signal Transduction
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
TORC1 Signaling
Protein Sequestering Activity
Macromolecule Catabolic Process
Nucleus
Regulation Of TOR Signaling
Negative Regulation Of TORC1 Signaling
Potassium Channel Regulator Activity
Regulation Of Intracellular Signal Transduction
MAPK Cascade
Negative Regulation Of Signal Transduction
Ubiquitin Protein Ligase Activity
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Protein Modification Process
Transferase Activity
Protein Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Polyubiquitination
Proteolysis Involved In Protein Catabolic Process
Zinc Ion Binding
Macromolecule Catabolic Process
Proteolysis
Macromolecule Metabolic Process
Metal Ion Binding
Catabolic Process
Protein Autoubiquitination
Proteasomal Protein Catabolic Process
Protein Catabolic Process
Protein K48-linked Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K63-linked Ubiquitination
Ubiquitin Ligase Complex
Cytoplasm
Protein Monoubiquitination
Response To Stress
Regulation Of Signal Transduction
Immune System Process
Cellular Response To Stress
Regulation Of Signaling
Regulation Of Cell Communication
Negative Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Ubiquitin-ubiquitin Ligase Activity
Positive Regulation Of Protein Ubiquitination
Suppression Of Viral Release By Host
Innate Immune Response
Positive Regulation Of Catabolic Process
Ubiquitin Protein Ligase Binding
Positive Regulation Of Post-translational Protein Modification
Regulation Of Post-translational Protein Modification
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Ubiquitin Binding
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Ubiquitination
Canonical NF-kappaB Signal Transduction
Defense Response To Symbiont
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Tagcloud (Difference)
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Tagcloud (Intersection)
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