LRP5 and MESDC2

Number of citations of the paper that reports this interaction (PMID 12581525)
47

Data Source:
HPRD (in vivo)

		LRP5	MESDC2
Gene Name		low density lipoprotein receptor-related protein 5	mesoderm development candidate 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane Receptor Complex	Cellular_component Endoplasmic Reticulum Plasma Membrane
	Molecular Function	Protein Binding Coreceptor Activity Wnt-protein Binding Toxin Transporter Activity Wnt-activated Receptor Activity	Molecular_function Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Gastrulation With Mouth Forming Second Positive Regulation Of Mesenchymal Cell Proliferation Osteoblast Development Glucose Catabolic Process Endocytosis Cholesterol Metabolic Process Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Wnt Signaling Pathway Embryonic Limb Morphogenesis Positive Regulation Of Osteoblast Proliferation Somatic Stem Cell Maintenance Extracellular Matrix-cell Signaling Cell Migration Involved In Gastrulation Cholesterol Homeostasis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Response To Peptide Hormone Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Bone Remodeling Regulation Of Bone Remodeling Bone Marrow Development Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Anatomical Structure Regression Retina Morphogenesis In Camera-type Eye Embryonic Retina Morphogenesis In Camera-type Eye Canonical Wnt Signaling Pathway Bone Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Adipose Tissue Development Cell-cell Signaling Involved In Mammary Gland Development Regulation Of Canonical Wnt Signaling Pathway Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Retinal Blood Vessel Morphogenesis Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Process Involved In Patterning Of Blood Vessels	Protein Folding Mesoderm Development Wnt Signaling Pathway Protein Localization To Cell Surface
Pathways		disassembly of the destruction complex and recruitment of AXIN to the membrane misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Bone mineral density ( 18455228 22504420) Bone mineral density (spine) ( 19801982)
Protein-Protein Interactions		8 interactors: AXIN1 CAPRIN2 DKK1 FZD8 MESDC2 SMAD9 THBS1 WNT1	9 interactors: APP ATP6V1E1 BRD4 KPNB1 LRP5 PSMA5 RFC3 SNX5 SNX7
Entrez ID		4041	23184
HPRD ID		04616	12129
Ensembl ID		ENSG00000162337	ENSG00000117899
Uniprot IDs		O75197	Q14696
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Canonical Wnt Signaling Pathway Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Wnt Signaling Pathway Positive Regulation Of Gene Expression Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Cellular Biosynthetic Process Forebrain Anterior/posterior Pattern Specification Positive Regulation Of Phosphorylation Canonical Wnt Signaling Pathway Anatomical Structure Development Tissue Development Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cellular Protein Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Developmental Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Mesoderm Development Positive Regulation Of Wnt Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Nervous System Development Skeletal System Development Positive Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Forebrain Regionalization System Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of MAP Kinase Activity Bone Development Regulation Of Signal Transduction Regulation Of Cell Differentiation Anterior/posterior Pattern Specification Brain Development Head Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process	Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Endocytosis Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Synaptic Growth At Neuromuscular Junction Cell-cell Signaling Involved In Mammary Gland Development Cholesterol Metabolic Process Viral Process Positive Regulation Of Canonical Wnt Signaling Pathway Sterol Metabolic Process Homeostatic Process Collateral Sprouting In Absence Of Injury Protein Transport Vesicle-mediated Transport Transition Metal Ion Homeostasis Establishment Of Protein Localization Negative Regulation Of DNA Damage Checkpoint Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Histone H3-K14 Acetylation Positive Regulation Of Wnt Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Retinal Blood Vessel Morphogenesis Collateral Sprouting Axon Midline Choice Point Recognition Cellular Homeostasis Extracellular Matrix-cell Signaling Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Glucose Catabolic Process Mitotic Cell Cycle Axon Choice Point Recognition Bone Marrow Development Negative Regulation Of Catalytic Activity Cellular Response To Stimulus Vesicle Organization Negative Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		3a 5a 7b 8b 9a avian axin2 branch branching canonical characterizes chick crosstalk dkk1 explants fgf fh535 gastrulation governed lrp6 morphogenesis pk115 player preserved recapitulates sfrp1 shh vertebrate wnt
Tagcloud (Difference) ?		3a 5a 7b 8b 9a avian axin2 branch branching canonical characterizes chick crosstalk dkk1 explants fgf fh535 gastrulation governed lrp6 morphogenesis pk115 player preserved recapitulates sfrp1 shh vertebrate wnt
Tagcloud (Intersection) ?