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MESDC2 and RFC3
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
MESDC2
RFC3
Gene Name
mesoderm development candidate 2
replication factor C (activator 1) 3, 38kDa
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Cellular_component
Endoplasmic Reticulum
Plasma Membrane
Nucleus
Nucleoplasm
DNA Replication Factor C Complex
Molecular Function
Molecular_function
Low-density Lipoprotein Particle Receptor Binding
DNA Binding
DNA Clamp Loader Activity
Protein Binding
ATPase Activity
Biological Process
Protein Folding
Mesoderm Development
Wnt Signaling Pathway
Protein Localization To Cell Surface
Mitotic Cell Cycle
Telomere Maintenance Via Recombination
Telomere Maintenance
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA Strand Elongation Involved In DNA Replication
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, DNA Gap Filling
Telomere Maintenance Via Semi-conservative Replication
Response To Organophosphorus
Pathways
Polymerase switching on the C-strand of the telomere
Nucleotide Excision Repair
Synthesis of DNA
Chromosome Maintenance
Lagging Strand Synthesis
Gap-filling DNA repair synthesis and ligation in TC-NER
G2/M Checkpoints
Extension of Telomeres
Repair synthesis for gap-filling by DNA polymerase in TC-NER
S Phase
Telomere C-strand (Lagging Strand) Synthesis
Leading Strand Synthesis
DNA strand elongation
Repair synthesis of patch ~27-30 bases long by DNA polymerase
Cell Cycle, Mitotic
Gap-filling DNA repair synthesis and ligation in GG-NER
Polymerase switching
Global Genomic NER (GG-NER)
Telomere Maintenance
Transcription-coupled NER (TC-NER)
Activation of ATR in response to replication stress
Cell Cycle Checkpoints
Drugs
Diseases
GWAS
Alzheimer's disease (
20061627
)
Obesity-related traits (
23251661
)
Protein-Protein Interactions
9 interactors:
APP
ATP6V1E1
BRD4
KPNB1
LRP5
PSMA5
RFC3
SNX5
SNX7
9 interactors:
ARFGAP1
BRD4
CHTF18
CHTF8
MESDC2
PCNA
RAD17
RFC1
RFC4
Entrez ID
23184
5983
HPRD ID
12129
02676
Ensembl ID
ENSG00000117899
ENSG00000133119
Uniprot IDs
Q14696
P40938
PDB IDs
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Cell Cycle Process
Positive Regulation Of Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle Phase Transition
Endocytosis
Regulation Of Cell Cycle Phase Transition
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G2/M Phase Transition
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain
Synaptic Growth At Neuromuscular Junction
Cell-cell Signaling Involved In Mammary Gland Development
Cholesterol Metabolic Process
Viral Process
Positive Regulation Of Canonical Wnt Signaling Pathway
Sterol Metabolic Process
Homeostatic Process
Collateral Sprouting In Absence Of Injury
Protein Transport
Vesicle-mediated Transport
Transition Metal Ion Homeostasis
Establishment Of Protein Localization
Negative Regulation Of DNA Damage Checkpoint
Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification
Histone H3-K14 Acetylation
Positive Regulation Of Wnt Signaling Pathway
G1/S Transition Of Mitotic Cell Cycle
Retinal Blood Vessel Morphogenesis
Collateral Sprouting
Axon Midline Choice Point Recognition
Cellular Homeostasis
Extracellular Matrix-cell Signaling
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Glucose Catabolic Process
Mitotic Cell Cycle
Axon Choice Point Recognition
Bone Marrow Development
Negative Regulation Of Catalytic Activity
Cellular Response To Stimulus
Vesicle Organization
Negative Regulation Of Cellular Protein Metabolic Process
DNA Replication
Nucleotide-excision Repair, DNA Gap Filling
Telomere Maintenance Via Semi-conservative Replication
Cell Cycle
Nuclear DNA Replication
Telomere Maintenance Via Recombination
Mitotic Recombination
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Telomere Maintenance Via Telomere Lengthening
Transcription-coupled Nucleotide-excision Repair
Cell Cycle Process
DNA Metabolic Process
DNA Recombination
Telomere Maintenance
Mitotic Cell Cycle
Cellular Response To Stress
Nucleotide-excision Repair
Cellular Response To DNA Damage Stimulus
DNA-dependent DNA Replication
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
DNA Repair
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Nuclease Activity
Nucleobase-containing Compound Metabolic Process
Organelle Organization
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Chromosome Organization
Positive Regulation Of Deoxyribonuclease Activity
Cellular Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Response To Stress
Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain
Leading Strand Elongation
Nitrogen Compound Metabolic Process
Regulation Of DNA Replication
Negative Regulation Of DNA Damage Checkpoint
Histone H3-K14 Acetylation
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Process
Cellular Homeostasis
Methotrexate Transport
Cellular Response To Stimulus
Histone H4-K12 Acetylation
Folic Acid Transport
Telomere Maintenance Via Telomerase
Mitotic Cell Cycle Phase Transition
Tagcloud
?
12q24
13q12
3q27
7q11
bands
catalyzed
chains
chromosomes
consisting
dnas
elongation
epsilon
hybrids
locations
mapped
multimeric
p145
p36
p37
p38
p40
panel
primer
processive
q13
q24
rfc2
rfc4
rfc5
Tagcloud (Difference)
?
12q24
13q12
3q27
7q11
bands
catalyzed
chains
chromosomes
consisting
dnas
elongation
epsilon
hybrids
locations
mapped
multimeric
p145
p36
p37
p38
p40
panel
primer
processive
q13
q24
rfc2
rfc4
rfc5
Tagcloud (Intersection)
?