LRP5 and CAPRIN2

Number of citations of the paper that reports this interaction (PubMedID 18762581)
29

Data Source:
BioGRID (affinity chromatography technology, pull down)

		LRP5	CAPRIN2
Description		LDL receptor related protein 5	caprin family member 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Membrane Receptor Complex Wnt-Frizzled-LRP5/6 Complex Wnt Signalosome	Nucleoplasm Cytoplasm Mitochondrion Centrosome Cytosol Plasma Membrane Membrane Receptor Complex
	Molecular Function	Protein Binding Coreceptor Activity Wnt-protein Binding Toxin Transmembrane Transporter Activity Wnt Receptor Activity	RNA Binding Signaling Receptor Binding Protein Binding Metal Ion Binding
	Biological Process	Gastrulation With Mouth Forming Second Vasculature Development Positive Regulation Of Mesenchymal Cell Proliferation Osteoblast Development Glucose Catabolic Process Amino Acid Transport Endocytosis Nervous System Development Mesodermal Cell Migration Cholesterol Metabolic Process Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Tissue Development Anterior/posterior Pattern Specification Gene Expression Wnt Signaling Pathway Osteoblast Proliferation Positive Regulation Of Osteoblast Proliferation Somatic Stem Cell Population Maintenance Limb Morphogenesis Extracellular Matrix-cell Signaling Cell Migration Involved In Gastrulation Cholesterol Homeostasis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Response To Peptide Hormone Small Molecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Fat Cell Differentiation Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Bone Remodeling Blood Vessel Morphogenesis Bone Marrow Development Anatomical Structure Regression Retina Morphogenesis In Camera-type Eye Canonical Wnt Signaling Pathway Bone Development Bone Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Duct Morphogenesis Adipose Tissue Development Cell-cell Signaling Involved In Mammary Gland Development Establishment Of Blood-brain Barrier Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Retina Vasculature Development In Camera-type Eye Retina Vasculature Morphogenesis In Camera-type Eye Retinal Blood Vessel Morphogenesis Regulation Of Biological Quality Cell-cell Adhesion Norrin Signaling Pathway Apoptotic Process Involved In Blood Vessel Morphogenesis Establishment Of Blood-retinal Barrier	Dorsal/ventral Axis Specification Negative Regulation Of Translation Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Dendrite Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination Signaling by LRP5 mutants Signaling by RNF43 mutants
Drugs
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND) Sclerosing bone dysplasias, including: Endosteal hyperostosis; Van Buchem disease, type 2; Osteopetrosis, autosomal dominant 1 (OPTA1) Osteoporosis-pseudoglioma syndrome (OPPG)
GWAS		Bone mineral density ( 18455228 24249740) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 28743860) Bone mineral density (spine) ( 19801982) Femoral neck bone mineral density ( 29499414) Femoral neck section modulus ( 30888730) Fractures ( 30158200) Heel bone mineral density ( 28869591 30598549) Hip index ( 34021172) Lumbar spine bone mineral density ( 22504420 29499414) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Monobrow ( 27182965)	A body shape index ( 34021172) Cataracts ( 34127677) Height ( 31562340) Metabolite levels ( 23823483) Offspring birth weight ( 31043758) Order dimension in obsessive compulsive disorder ( 32424139)
Interacting Genes		9 interacting genes: AXIN1 CAPRIN2 DKK1 FZD8 MESD MTDH SMAD9 THBS1 WNT1	4 interacting genes: LRP5 MEOX2 PEX5 RNF10
Entrez ID		4041	65981
HPRD ID		04616	12711
Ensembl ID		ENSG00000162337	ENSG00000110888
Uniprot IDs		O75197	A0A8I5KRN0 A0A8I5KSM9 A0A8I5KZC0 A0A8Q3SHS5 A0A8Q3WKC4 F5GXI7 F5H5J8 Q6IMN6
PDB IDs			4OUL 4OUM 5J97 8K9C 8K9D
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Canonical Wnt Signaling Pathway Negative Regulation Of CGMP-mediated Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Axis Specification Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Regulation Of CGMP-mediated Signaling Regulation Of Cellular Response To Growth Factor Stimulus Dorsal/ventral Axis Specification Regulation Of Wnt Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process I-SMAD Binding Negative Regulation Of Cellular Response To Growth Factor Stimulus Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Metabolic Process Heart Valve Development Regulation Of Cell Communication Regulation Of Signaling Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Macromolecule Biosynthetic Process Developmental Process CGMP-mediated Signaling Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Protein Metabolic Process T Cell Differentiation In Thymus Mesoderm Formation Regulation Of Intracellular Signal Transduction Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Developmental Process Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Negative Regulation Of Fat Cell Differentiation Formation Of Primary Germ Layer Beta-catenin Destruction Complex Assembly Mesoderm Development Positive Regulation Of Midbrain Dopaminergic Neuron Differentiation	Protein Monoubiquitination Wnt Signalosome Pattern Specification Process Wnt-Frizzled-LRP5/6 Complex Gastrulation With Mouth Forming Second Mesodermal Cell Migration Cell-cell Signaling Involved In Mammary Gland Development Retina Vasculature Morphogenesis In Camera-type Eye Wnt Receptor Activity Establishment Of Blood-brain Barrier Apoptotic Process Involved In Blood Vessel Morphogenesis Toxin Transmembrane Transporter Activity Positive Regulation Of RNA Biosynthetic Process Osteoblast Proliferation Bone Marrow Development Retinal Blood Vessel Morphogenesis Anatomical Structure Regression Mammary Gland Duct Morphogenesis Positive Regulation Of DNA-templated Transcription Extracellular Matrix-cell Signaling Retina Morphogenesis In Camera-type Eye Bone Remodeling Retina Vasculature Development In Camera-type Eye Cell Migration Involved In Gastrulation Norrin Signaling Pathway Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Transcription By RNA Polymerase II Osteoblast Development Establishment Of Blood-retinal Barrier Segment Specification Somite Development Somite Specification Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Membrane Peroxisome Membrane Targeting Sequence Binding Protein Unfolding Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Substrate Release Peroxisome Matrix Targeting Signal-1 Binding Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Carrier Chaperone Peroxisome Targeting Sequence Binding Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Pexophagy Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Negative Regulation Of Glial Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane
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