LRP5 and CAPRIN2

Number of citations of the paper that reports this interaction (PMID 18762581)
15

Data Source:
BioGRID (affinity chromatography technology, pull down)

		LRP5	CAPRIN2
Gene Name		low density lipoprotein receptor-related protein 5	caprin family member 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane Receptor Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Centrosome Receptor Complex
	Molecular Function	Protein Binding Coreceptor Activity Wnt-protein Binding Toxin Transporter Activity Wnt-activated Receptor Activity	RNA Binding Receptor Binding Protein Binding
	Biological Process	Gastrulation With Mouth Forming Second Positive Regulation Of Mesenchymal Cell Proliferation Osteoblast Development Glucose Catabolic Process Endocytosis Cholesterol Metabolic Process Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Wnt Signaling Pathway Embryonic Limb Morphogenesis Positive Regulation Of Osteoblast Proliferation Somatic Stem Cell Maintenance Extracellular Matrix-cell Signaling Cell Migration Involved In Gastrulation Cholesterol Homeostasis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Response To Peptide Hormone Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Bone Remodeling Regulation Of Bone Remodeling Bone Marrow Development Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Anatomical Structure Regression Retina Morphogenesis In Camera-type Eye Embryonic Retina Morphogenesis In Camera-type Eye Canonical Wnt Signaling Pathway Bone Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Adipose Tissue Development Cell-cell Signaling Involved In Mammary Gland Development Regulation Of Canonical Wnt Signaling Pathway Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Retinal Blood Vessel Morphogenesis Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Process Involved In Patterning Of Blood Vessels	Negative Regulation Of Translation Negative Regulation Of Cell Growth Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Dendrite Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		disassembly of the destruction complex and recruitment of AXIN to the membrane misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Bone mineral density ( 18455228 22504420) Bone mineral density (spine) ( 19801982)
Protein-Protein Interactions		8 interactors: AXIN1 CAPRIN2 DKK1 FZD8 MESDC2 SMAD9 THBS1 WNT1	2 interactors: LRP5 PEX5
Entrez ID		4041	65981
HPRD ID		04616	12711
Ensembl ID		ENSG00000162337	ENSG00000110888
Uniprot IDs		O75197	Q6IMN6
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Canonical Wnt Signaling Pathway Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Wnt Signaling Pathway Positive Regulation Of Gene Expression Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Cellular Biosynthetic Process Forebrain Anterior/posterior Pattern Specification Positive Regulation Of Phosphorylation Canonical Wnt Signaling Pathway Anatomical Structure Development Tissue Development Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cellular Protein Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Developmental Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Mesoderm Development Positive Regulation Of Wnt Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Nervous System Development Skeletal System Development Positive Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Forebrain Regionalization System Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of MAP Kinase Activity Bone Development Regulation Of Signal Transduction Regulation Of Cell Differentiation Anterior/posterior Pattern Specification Brain Development Head Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process	Negative Regulation Of Protein Homotetramerization Cell-cell Signaling Involved In Mammary Gland Development Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Retinal Blood Vessel Morphogenesis Negative Regulation Of Protein Homooligomerization Glucose Catabolic Process Extracellular Matrix-cell Signaling Bone Marrow Development Protein Import Into Peroxisome Membrane Apoptotic Process Involved In Patterning Of Blood Vessels Protein To Membrane Docking Peroxisomal Membrane Transport Negative Regulation Of Protein Oligomerization Positive Regulation Of Osteoblast Proliferation Retina Vasculature Morphogenesis In Camera-type Eye Protein Import Into Peroxisome Matrix Embryonic Retina Morphogenesis In Camera-type Eye Cell Migration Cell Migration Involved In Gastrulation Anatomical Structure Regression Cell Motility Retina Vasculature Development In Camera-type Eye Regulation Of Osteoblast Proliferation Apoptotic Process Involved In Morphogenesis Establishment Of Protein Localization To Peroxisome Protein Targeting To Peroxisome Dorsal/ventral Axis Specification Very Long-chain Fatty Acid Metabolic Process Osteoblast Development Apoptotic Process Involved In Development Cerebral Cortex Neuron Differentiation Regulation Of Protein Oligomerization Locomotion Lipid Metabolic Process Adipose Tissue Development Developmental Programmed Cell Death Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Mitotic Nuclear Division Endoplasmic Reticulum Organization Fatty Acid Beta-oxidation Positive Regulation Of Mesenchymal Cell Proliferation Peroxisome Organization Regulation Of Bone Remodeling Embryonic Eye Morphogenesis Positive Regulation Of Multicellular Organism Growth Patterning Of Blood Vessels Movement Of Cell Or Subcellular Component Negative Regulation Of Osteoblast Differentiation
Tagcloud ?		3a 5a 7b 8b 9a avian axin2 branch branching canonical characterizes chick crosstalk dkk1 explants fgf fh535 gastrulation governed lrp6 morphogenesis pk115 player preserved recapitulates sfrp1 shh vertebrate wnt
Tagcloud (Difference) ?		3a 5a 7b 8b 9a avian axin2 branch branching canonical characterizes chick crosstalk dkk1 explants fgf fh535 gastrulation governed lrp6 morphogenesis pk115 player preserved recapitulates sfrp1 shh vertebrate wnt
Tagcloud (Intersection) ?