MESD and ABCG8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MESD	ABCG8
Description		mesoderm development LRP chaperone	ATP binding cassette subfamily G member 8
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane	Plasma Membrane Membrane Apical Plasma Membrane ATP-binding Cassette (ABC) Transporter Complex Receptor Complex
	Molecular Function	Protein Binding Identical Protein Binding Protein Folding Chaperone Low-density Lipoprotein Particle Receptor Binding	Protein Binding ATP Binding ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Metal Ion Binding Protein Heterodimerization Activity Protein Dimerization Activity Cholesterol Transfer Activity ABC-type Transporter Activity
	Biological Process	Ossification Protein Folding Phagocytosis Mesoderm Development Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Protein Localization To Cell Surface Protein Localization To Plasma Membrane Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering	Lipid Transport Response To Nutrient Response To Xenobiotic Stimulus Negative Regulation Of Intestinal Phytosterol Absorption Response To Muscle Activity Phospholipid Transport Sterol Transport Intestinal Cholesterol Absorption Response To Nutrient Levels Cholesterol Efflux Cholesterol Homeostasis Negative Regulation Of Intestinal Cholesterol Absorption Transmembrane Transport Sterol Homeostasis Triglyceride Homeostasis
Pathways			ABC transporters in lipid homeostasis Defective ABCG8 causes GBD4 and sitosterolemia Defective ABCG5 causes sitosterolemia NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases			Sitosterolemia
GWAS			Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 34315874 33547301) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 34315874) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 25961943 28270201 24097068 20686565) Coronary artery disease ( 33020668 29212778 32469254) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Gallstone disease ( 27094239 30504769 30692554 30325047 17632509) LDL cholesterol ( 19060906 20686565 23726366 25961943 30275531) LDL cholesterol levels ( 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222) Liver enzyme levels (alanine transaminase) ( 33972514) Low density lipoprotein cholesterol levels ( 33339817 32154731) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (antithrombotic agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Phytosterol levels ( 20529992) Refractive error ( 32231278) Total cholesterol levels ( 30275531 33339817)
Interacting Genes		78 interacting genes: - ABCG8 ABITRAM ACBD7 AKIRIN2 AKNAD1 AKT1 APP ARB2A ASH2L ATP6V1E1 ATP6V1E2 BORCS8 BORCS8-MEF2B BRD4 C17orf75 CDR2L CENATAC CENPH CHCHD1 CLP1 CNOT9 COL10A1 COL1A2 COX14 COX5A CUTC CYP4F11 DDX6 ENKD1 FAM13C FARS2 FCER1A GEM GOLGA7 GPKOW GTPBP3 H2AB2 H2AB3 HSBP1L1 IGF1 KLHL20 KPNB1 LCE1A LRP5 LY96 MAGEB4 MAP1LC3B MAPDA MCM9 MELTF MKNK2 MRM1 MTNR1A NAA35 NRDE2 PMF1 PSMA5 QARS1 RCOR3 RFC3 SLC6A20 SMARCB1 SNX5 SNX7 TEKTL1 TEX12 TEX48 TPM2 TREX2 TRMT2A TTC21A TTC23 TYMP UBQLN1 ZNF493 ZNF827 ZNF844	9 interacting genes: ABCG5 AGPAT2 AKT2 ANG LMNB1 MAL2 MESD NR4A1 NUPR1
Entrez ID		23184	64241
HPRD ID		12129	05679
Ensembl ID		ENSG00000117899	ENSG00000143921
Uniprot IDs		Q14696	Q9H221
PDB IDs			5DO7 7JR7 7R87 7R88 7R89 7R8A 7R8B 8CUB
Enriched GO Terms of Interacting Partners?		Protein Binding Proton-transporting Two-sector ATPase Complex, Catalytic Domain	Regulation Of Type B Pancreatic Cell Proliferation
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