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MESDC2 and LRP5
Number of citations of the paper that reports this interaction (PMID
12581525
)
47
Data Source:
HPRD
(in vivo)
MESDC2
LRP5
Gene Name
mesoderm development candidate 2
low density lipoprotein receptor-related protein 5
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Cellular_component
Endoplasmic Reticulum
Plasma Membrane
Mitochondrion
Endoplasmic Reticulum
Plasma Membrane
Integral Component Of Membrane
Receptor Complex
Molecular Function
Molecular_function
Low-density Lipoprotein Particle Receptor Binding
Protein Binding
Coreceptor Activity
Wnt-protein Binding
Toxin Transporter Activity
Wnt-activated Receptor Activity
Biological Process
Protein Folding
Mesoderm Development
Wnt Signaling Pathway
Protein Localization To Cell Surface
Gastrulation With Mouth Forming Second
Positive Regulation Of Mesenchymal Cell Proliferation
Osteoblast Development
Glucose Catabolic Process
Endocytosis
Cholesterol Metabolic Process
Regulation Of Blood Pressure
Positive Regulation Of Cell Proliferation
Anterior/posterior Pattern Specification
Wnt Signaling Pathway
Embryonic Limb Morphogenesis
Positive Regulation Of Osteoblast Proliferation
Somatic Stem Cell Maintenance
Extracellular Matrix-cell Signaling
Cell Migration Involved In Gastrulation
Cholesterol Homeostasis
Embryonic Digit Morphogenesis
Regulation Of Apoptotic Process
Response To Peptide Hormone
Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification
Positive Regulation Of Fat Cell Differentiation
Negative Regulation Of Osteoblast Differentiation
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Bone Remodeling
Regulation Of Bone Remodeling
Bone Marrow Development
Embryonic Camera-type Eye Morphogenesis
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Anatomical Structure Regression
Retina Morphogenesis In Camera-type Eye
Embryonic Retina Morphogenesis In Camera-type Eye
Canonical Wnt Signaling Pathway
Bone Morphogenesis
Branching Involved In Mammary Gland Duct Morphogenesis
Adipose Tissue Development
Cell-cell Signaling Involved In Mammary Gland Development
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Retinal Blood Vessel Morphogenesis
Negative Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Canonical Wnt Signaling Pathway
Apoptotic Process Involved In Patterning Of Blood Vessels
Pathways
disassembly of the destruction complex and recruitment of AXIN to the membrane
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
regulation of FZD by ubiquitination
RNF mutants show enhanced WNT signaling and proliferation
negative regulation of TCF-dependent signaling by WNT ligand antagonists
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by Wnt
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Bone mineral density (
18455228
22504420
)
Bone mineral density (spine) (
19801982
)
Protein-Protein Interactions
9 interactors:
APP
ATP6V1E1
BRD4
KPNB1
LRP5
PSMA5
RFC3
SNX5
SNX7
8 interactors:
AXIN1
CAPRIN2
DKK1
FZD8
MESDC2
SMAD9
THBS1
WNT1
Entrez ID
23184
4041
HPRD ID
12129
04616
Ensembl ID
ENSG00000117899
ENSG00000162337
Uniprot IDs
Q14696
O75197
PDB IDs
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Cell Cycle Process
Positive Regulation Of Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle Phase Transition
Endocytosis
Regulation Of Cell Cycle Phase Transition
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G2/M Phase Transition
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain
Synaptic Growth At Neuromuscular Junction
Cell-cell Signaling Involved In Mammary Gland Development
Cholesterol Metabolic Process
Viral Process
Positive Regulation Of Canonical Wnt Signaling Pathway
Sterol Metabolic Process
Homeostatic Process
Collateral Sprouting In Absence Of Injury
Protein Transport
Vesicle-mediated Transport
Transition Metal Ion Homeostasis
Establishment Of Protein Localization
Negative Regulation Of DNA Damage Checkpoint
Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification
Histone H3-K14 Acetylation
Positive Regulation Of Wnt Signaling Pathway
G1/S Transition Of Mitotic Cell Cycle
Retinal Blood Vessel Morphogenesis
Collateral Sprouting
Axon Midline Choice Point Recognition
Cellular Homeostasis
Extracellular Matrix-cell Signaling
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Glucose Catabolic Process
Mitotic Cell Cycle
Axon Choice Point Recognition
Bone Marrow Development
Negative Regulation Of Catalytic Activity
Cellular Response To Stimulus
Vesicle Organization
Negative Regulation Of Cellular Protein Metabolic Process
Wnt Signaling Pathway
Regulation Of Protein Phosphorylation
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Phosphorylation
Positive Regulation Of Protein Phosphorylation
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Gene Expression
Wnt Signaling Pathway Involved In Somitogenesis
Positive Regulation Of Cellular Biosynthetic Process
Forebrain Anterior/posterior Pattern Specification
Positive Regulation Of Phosphorylation
Canonical Wnt Signaling Pathway
Anatomical Structure Development
Tissue Development
Negative Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Peptidyl-serine Phosphorylation
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Anatomical Structure Formation Involved In Morphogenesis
Developmental Process
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Mesoderm Development
Positive Regulation Of Wnt Signaling Pathway
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Nervous System Development
Skeletal System Development
Positive Regulation Of Signal Transduction
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Transcription, DNA-templated
Anatomical Structure Morphogenesis
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Forebrain Regionalization
System Development
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of MAP Kinase Activity
Bone Development
Regulation Of Signal Transduction
Regulation Of Cell Differentiation
Anterior/posterior Pattern Specification
Brain Development
Head Development
Positive Regulation Of Protein Serine/threonine Kinase Activity
Negative Regulation Of Cellular Protein Metabolic Process
Tagcloud
?
3a
5a
7b
8b
9a
avian
axin2
branch
branching
canonical
characterizes
chick
crosstalk
dkk1
explants
fgf
fh535
gastrulation
governed
lrp6
morphogenesis
pk115
player
preserved
recapitulates
sfrp1
shh
vertebrate
wnt
Tagcloud (Difference)
?
3a
5a
7b
8b
9a
avian
axin2
branch
branching
canonical
characterizes
chick
crosstalk
dkk1
explants
fgf
fh535
gastrulation
governed
lrp6
morphogenesis
pk115
player
preserved
recapitulates
sfrp1
shh
vertebrate
wnt
Tagcloud (Intersection)
?