MESD and SNX5

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MESD	SNX5
Description		mesoderm development LRP chaperone	sorting nexin 5
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane	Ruffle Phagocytic Cup Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Brush Border Cytoplasmic Side Of Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Retromer Complex Retromer, Tubulation Complex Cytoplasmic Vesicle Early Endosome Membrane Cell Projection Perinuclear Region Of Cytoplasm Macropinocytic Cup Tubular Endosome Cytoplasmic Side Of Early Endosome Membrane
	Molecular Function	Protein Binding Identical Protein Binding Protein Folding Chaperone Low-density Lipoprotein Particle Receptor Binding	Protein Binding Lipid Binding Phosphatidylinositol-5-phosphate Binding D1 Dopamine Receptor Binding Dynactin Binding Phosphatidylinositol Binding Cadherin Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Ossification Protein Folding Phagocytosis Mesoderm Development Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Protein Localization To Cell Surface Protein Localization To Plasma Membrane Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering	Intracellular Protein Transport Endocytosis Pinocytosis Epidermal Growth Factor Catabolic Process Protein Transport Regulation Of Macroautophagy Retrograde Transport, Endosome To Golgi Negative Regulation Of Blood Pressure Positive Regulation Of DNA-templated Transcription Positive Regulation Of Insulin Receptor Signaling Pathway
Pathways			Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS			Apolipoprotein B levels ( 32203549) Cholesterol, total ( 25961943) LDL cholesterol ( 24097068 25961943) LDL cholesterol levels ( 28334899 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alanine transaminase) ( 33972514) Low density lipoprotein cholesterol levels ( 33339817)
Interacting Genes		78 interacting genes: - ABCG8 ABITRAM ACBD7 AKIRIN2 AKNAD1 AKT1 APP ARB2A ASH2L ATP6V1E1 ATP6V1E2 BORCS8 BORCS8-MEF2B BRD4 C17orf75 CDR2L CENATAC CENPH CHCHD1 CLP1 CNOT9 COL10A1 COL1A2 COX14 COX5A CUTC CYP4F11 DDX6 ENKD1 FAM13C FARS2 FCER1A GEM GOLGA7 GPKOW GTPBP3 H2AB2 H2AB3 HSBP1L1 IGF1 KLHL20 KPNB1 LCE1A LRP5 LY96 MAGEB4 MAP1LC3B MAPDA MCM9 MELTF MKNK2 MRM1 MTNR1A NAA35 NRDE2 PMF1 PSMA5 QARS1 RCOR3 RFC3 SLC6A20 SMARCB1 SNX5 SNX7 TEKTL1 TEX12 TEX48 TPM2 TREX2 TRMT2A TTC21A TTC23 TYMP UBQLN1 ZNF493 ZNF827 ZNF844	21 interacting genes: APPBP2 AQP2 BANP CDC37 CLTC CLTCL1 DNAJB11 DSCR9 FANCA HGS HMOX2 ITSN1 LAMTOR5 MESD MIB1 NRP1 OGT PFDN1 PRKRA PSMB8 RIGI
Entrez ID		23184	27131
HPRD ID		12129	10439
Ensembl ID		ENSG00000117899	ENSG00000089006
Uniprot IDs		Q14696	Q6P5V6 Q9Y5X3
PDB IDs			1SYS 5TGH 5TGI 5TGJ 5WY2 6N5X 6N5Y 6N5Z 8A1G 8ABQ 8AFZ
Enriched GO Terms of Interacting Partners?		Protein Binding Proton-transporting Two-sector ATPase Complex, Catalytic Domain	Cytoplasmic Vesicle Membrane Clathrin Coat Of Trans-Golgi Network Vesicle Endocytosis Clathrin Complex Receptor-mediated Endocytosis Clathrin Light Chain Binding Sorting Endosome Protein Localization To Lysosome Import Into Cell Double-stranded RNA Binding Clathrin-coated Pit Protein Folding Intracellular Protein Localization Protein Localization To Vacuole Cytoplasm Endosomal Transport Clathrin-coated Endocytic Vesicle Unfolded Protein Binding Cytoplasmic Vesicle Low-density Lipoprotein Particle Receptor Binding Recycling Endosome Clathrin-dependent Endocytosis Protein Folding Chaperone Complex Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization To Membrane Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Otic Placode Development Basal Dendrite Development
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