MESDC2 and PSMA5

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		MESDC2	PSMA5
Gene Name		mesoderm development candidate 2	proteasome (prosome, macropain) subunit, alpha type, 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Endoplasmic Reticulum Plasma Membrane	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Alpha-subunit Complex Extracellular Vesicular Exosome
	Molecular Function	Molecular_function Low-density Lipoprotein Particle Receptor Binding	Threonine-type Endopeptidase Activity Protein Binding
	Biological Process	Protein Folding Mesoderm Development Wnt Signaling Pathway Protein Localization To Cell Surface	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway
Drugs
Diseases
GWAS			Chronic kidney disease ( 20383146)
Protein-Protein Interactions		9 interactors: APP ATP6V1E1 BRD4 KPNB1 LRP5 PSMA5 RFC3 SNX5 SNX7	10 interactors: APP CCR5 FANCA MESDC2 MTRNR2L1 PLK1 PSEN1 PSMA4 PSMA7 YWHAZ
Entrez ID		23184	5686
HPRD ID		12129	01464
Ensembl ID		ENSG00000117899	ENSG00000143106
Uniprot IDs		Q14696	P28066
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Endocytosis Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Synaptic Growth At Neuromuscular Junction Cell-cell Signaling Involved In Mammary Gland Development Cholesterol Metabolic Process Viral Process Positive Regulation Of Canonical Wnt Signaling Pathway Sterol Metabolic Process Homeostatic Process Collateral Sprouting In Absence Of Injury Protein Transport Vesicle-mediated Transport Transition Metal Ion Homeostasis Establishment Of Protein Localization Negative Regulation Of DNA Damage Checkpoint Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Histone H3-K14 Acetylation Positive Regulation Of Wnt Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Retinal Blood Vessel Morphogenesis Collateral Sprouting Axon Midline Choice Point Recognition Cellular Homeostasis Extracellular Matrix-cell Signaling Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Glucose Catabolic Process Mitotic Cell Cycle Axon Choice Point Recognition Bone Marrow Development Negative Regulation Of Catalytic Activity Cellular Response To Stimulus Vesicle Organization Negative Regulation Of Cellular Protein Metabolic Process	Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Response To Stress Regulation Of Proteolysis Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cell Cycle Positive Regulation Of Ligase Activity Negative Regulation Of Transferase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Ubiquitination Cellular Response To DNA Damage Stimulus Negative Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Cellular Response To Stimulus Apoptotic Process Negative Regulation Of Cell Death Positive Regulation Of Protein Ubiquitination Programmed Cell Death Regulation Of Protein Binding Cell Death Negative Regulation Of Mitotic Cell Cycle Phase Transition Death Regulation Of Cell Cycle Process DNA Damage Checkpoint Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Checkpoint Positive Regulation Of Transferase Activity Immune System Process Positive Regulation Of Protein Metabolic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity
Tagcloud ?			20s alpha5 alpha6 alpha7 alphal apparatus cations dephosphorylation electrophoretic endonuclease endoribonuclease hydrolysates possession postranslational proteasomal proteasome proteasomes proteolysis psma1 psma3 psma6 ptm ribonucleoprotein rnase scarcely spectrometric tryptic utr varies
Tagcloud (Difference) ?			20s alpha5 alpha6 alpha7 alphal apparatus cations dephosphorylation electrophoretic endonuclease endoribonuclease hydrolysates possession postranslational proteasomal proteasome proteasomes proteolysis psma1 psma3 psma6 ptm ribonucleoprotein rnase scarcely spectrometric tryptic utr varies
Tagcloud (Intersection) ?