LRP5 and FZD8

Number of citations of the paper that reports this interaction (PMID 11448771)
150

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		LRP5	FZD8
Gene Name		low density lipoprotein receptor-related protein 5	frizzled class receptor 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane Receptor Complex	Golgi Apparatus Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Coreceptor Activity Wnt-protein Binding Toxin Transporter Activity Wnt-activated Receptor Activity	G-protein Coupled Receptor Activity Receptor Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity
	Biological Process	Gastrulation With Mouth Forming Second Positive Regulation Of Mesenchymal Cell Proliferation Osteoblast Development Glucose Catabolic Process Endocytosis Cholesterol Metabolic Process Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Wnt Signaling Pathway Embryonic Limb Morphogenesis Positive Regulation Of Osteoblast Proliferation Somatic Stem Cell Maintenance Extracellular Matrix-cell Signaling Cell Migration Involved In Gastrulation Cholesterol Homeostasis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Response To Peptide Hormone Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Bone Remodeling Regulation Of Bone Remodeling Bone Marrow Development Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Anatomical Structure Regression Retina Morphogenesis In Camera-type Eye Embryonic Retina Morphogenesis In Camera-type Eye Canonical Wnt Signaling Pathway Bone Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Adipose Tissue Development Cell-cell Signaling Involved In Mammary Gland Development Regulation Of Canonical Wnt Signaling Pathway Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Retinal Blood Vessel Morphogenesis Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Process Involved In Patterning Of Blood Vessels	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis G-protein Coupled Receptor Signaling Pathway Neuron Differentiation T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway
Pathways		disassembly of the destruction complex and recruitment of AXIN to the membrane misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination Asymmetric localization of PCP proteins XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Bone mineral density ( 18455228 22504420) Bone mineral density (spine) ( 19801982)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Periodontal microbiota ( 22699663) Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		8 interactors: AXIN1 CAPRIN2 DKK1 FZD8 MESDC2 SMAD9 THBS1 WNT1	5 interactors: GOPC LRP5 LRP6 RYK WNT1
Entrez ID		4041	8325
HPRD ID		04616	05852
Ensembl ID		ENSG00000162337	ENSG00000177283
Uniprot IDs		O75197	Q9H461
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Canonical Wnt Signaling Pathway Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Wnt Signaling Pathway Positive Regulation Of Gene Expression Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Cellular Biosynthetic Process Forebrain Anterior/posterior Pattern Specification Positive Regulation Of Phosphorylation Canonical Wnt Signaling Pathway Anatomical Structure Development Tissue Development Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cellular Protein Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Developmental Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Mesoderm Development Positive Regulation Of Wnt Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Nervous System Development Skeletal System Development Positive Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Forebrain Regionalization System Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of MAP Kinase Activity Bone Development Regulation Of Signal Transduction Regulation Of Cell Differentiation Anterior/posterior Pattern Specification Brain Development Head Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process	Wnt Signaling Pathway Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Canonical Wnt Signaling Pathway Axis Specification Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Fat Cell Differentiation Midbrain-hindbrain Boundary Development Positive Regulation Of Wnt Signaling Pathway Embryonic Retina Morphogenesis In Camera-type Eye Cell Migration Involved In Gastrulation Rostrocaudal Neural Tube Patterning Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Canonical Wnt Signaling Pathway Bone Development Dorsal/ventral Axis Specification Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Anterior/posterior Pattern Specification Regulation Of Wnt Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Embryonic Organ Morphogenesis Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Bone Remodeling Embryonic Eye Morphogenesis Regulation Of Mesenchymal Cell Proliferation Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Signal Transduction Epithelial Tube Morphogenesis Cerebellum Morphogenesis Regulation Of Phosphorylation Hindbrain Morphogenesis Gastrulation With Mouth Forming Second Retina Morphogenesis In Camera-type Eye Bone Remodeling Tube Morphogenesis Negative Regulation Of Fat Cell Differentiation Embryonic Camera-type Eye Development Neural Tube Patterning Forebrain Development Cell Differentiation Response To Peptide Hormone Mammary Gland Duct Morphogenesis Regulation Of Phosphorus Metabolic Process Regulation Of Tissue Remodeling Pattern Specification Process Response To Peptide Embryonic Organ Development Gland Development
Tagcloud ?		3a 5a 7b 8b 9a avian axin2 branch branching canonical characterizes chick crosstalk dkk1 explants fgf fh535 gastrulation governed lrp6 morphogenesis pk115 player preserved recapitulates sfrp1 shh vertebrate wnt	aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd5 granulocyte hes6 hic1 hypermethylated hypomorphic island itpka leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring
Tagcloud (Difference) ?		3a 5a 7b 8b 9a avian axin2 branch branching canonical characterizes chick crosstalk dkk1 explants fgf fh535 gastrulation governed lrp6 morphogenesis pk115 player preserved recapitulates sfrp1 shh vertebrate wnt	aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd5 granulocyte hes6 hic1 hypermethylated hypomorphic island itpka leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring
Tagcloud (Intersection) ?