LRP5 and FZD8

Number of citations: 0 (PubMedID 11448771)
Data Source: BioGRID (pull down), HPRD (in vivo)

		LRP5	FZD8
Name		LDL receptor related protein 5	frizzled class receptor 8
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Membrane Receptor Complex Wnt-Frizzled-LRP5/6 Complex Wnt Signalosome	Golgi Apparatus Plasma Membrane Membrane Neuronal Dense Core Vesicle Wnt-Frizzled-LRP5/6 Complex
	Molecular Function	Protein Binding Coreceptor Activity Wnt-protein Binding Toxin Transmembrane Transporter Activity Wnt Receptor Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Wnt Receptor Activity
	Biological Process	Gastrulation With Mouth Forming Second Vasculature Development Positive Regulation Of Mesenchymal Cell Proliferation Osteoblast Development Glucose Catabolic Process Amino Acid Transport Endocytosis Nervous System Development Mesodermal Cell Migration Cholesterol Metabolic Process Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Tissue Development Anterior/posterior Pattern Specification Gene Expression Wnt Signaling Pathway Osteoblast Proliferation Positive Regulation Of Osteoblast Proliferation Somatic Stem Cell Population Maintenance Limb Morphogenesis Extracellular Matrix-cell Signaling Cell Migration Involved In Gastrulation Cholesterol Homeostasis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Response To Peptide Hormone Small Molecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Fat Cell Differentiation Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Bone Remodeling Blood Vessel Morphogenesis Bone Marrow Development Anatomical Structure Regression Retina Morphogenesis In Camera-type Eye Canonical Wnt Signaling Pathway Bone Development Bone Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Duct Morphogenesis Adipose Tissue Development Cell-cell Signaling Involved In Mammary Gland Development Establishment Of Blood-brain Barrier Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Retina Vasculature Development In Camera-type Eye Retina Vasculature Morphogenesis In Camera-type Eye Retinal Blood Vessel Morphogenesis Regulation Of Biological Quality Cell-cell Adhesion Norrin Signaling Pathway Apoptotic Process Involved In Blood Vessel Morphogenesis Establishment Of Blood-retinal Barrier	Angiogenesis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway Neuron Differentiation T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination Signaling by LRP5 mutants Signaling by RNF43 mutants	Class B/2 (Secretin family receptors) Asymmetric localization of PCP proteins Regulation of FZD by ubiquitination Signaling by RNF43 mutants
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND) Sclerosing bone dysplasias, including: Endosteal hyperostosis; Van Buchem disease, type 2; Osteopetrosis, autosomal dominant 1 (OPTA1) Osteoporosis-pseudoglioma syndrome (OPPG)	None
GWAS		Bone mineral density ( 18455228 24249740 ) Bone mineral density (paediatric, skull) ( 24945404 ) Bone mineral density (paediatric, total body less head) ( 28743860 ) Bone mineral density (spine) ( 19801982 ) Femoral neck bone mineral density ( 29499414 ) Femoral neck section modulus ( 30888730 ) Fractures ( 30158200 ) Heel bone mineral density ( 28869591 30598549 ) Hip index ( 34021172 ) Lumbar spine bone mineral density ( 22504420 29499414 ) Medication use (drugs affecting bone structure and mineralization) ( 31015401 ) Monobrow ( 27182965 )	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Periodontal microbiota ( 22699663 ) Protein quantitative trait loci ( 18464913 )
Novel Interactors		1 novel interactors: PDE2A	2 novel interactors: CUL2 RAE1
Interacting Genes		9 interacting genes: AXIN1 CAPRIN2 DKK1 FZD8 MESD MTDH SMAD9 THBS1 WNT1	5 interacting genes: GOPC LRP5 LRP6 RYK WNT1
Entrez ID		4041	8325
HPRD ID		04616	05852
Ensembl ID		ENSG00000162337	ENSG00000177283
Uniprot IDs		O75197	Q9H461
PDB IDs		Not available	5UN5 5UN6 6NDZ 8X0T
GO Terms Enriched among Interactors		Wnt Signaling Pathway Canonical Wnt Signaling Pathway Negative Regulation Of CGMP-mediated Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Axis Specification Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Regulation Of CGMP-mediated Signaling Regulation Of Cellular Response To Growth Factor Stimulus Dorsal/ventral Axis Specification Regulation Of Wnt Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process I-SMAD Binding Negative Regulation Of Cellular Response To Growth Factor Stimulus Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Metabolic Process Heart Valve Development Regulation Of Cell Communication Regulation Of Signaling Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Macromolecule Biosynthetic Process Developmental Process CGMP-mediated Signaling Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Protein Metabolic Process T Cell Differentiation In Thymus Mesoderm Formation Regulation Of Intracellular Signal Transduction Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Developmental Process Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Negative Regulation Of Fat Cell Differentiation Formation Of Primary Germ Layer Beta-catenin Destruction Complex Assembly Mesoderm Development Positive Regulation Of Midbrain Dopaminergic Neuron Differentiation	Midbrain Dopaminergic Neuron Differentiation Wnt Receptor Activity Canonical Wnt Signaling Pathway Wnt-protein Binding Frizzled Binding Dopaminergic Neuron Differentiation Wnt-Frizzled-LRP5/6 Complex Coreceptor Activity Wnt Signaling Pathway Toxin Transmembrane Transporter Activity Wnt Signalosome Central Nervous System Neuron Differentiation Midbrain Development Response To Peptide Hormone Neuron Differentiation Bone Development Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Negative Regulation Of Anion Channel Activity Cell-cell Signaling Involved In Mammary Gland Development Chemorepulsion Of Dopaminergic Neuron Axon Positive Regulation Of Cell Proliferation In Midbrain Central Nervous System Morphogenesis Diencephalon Development Neurogenesis Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Dermatome Development Astrocyte-dopaminergic Neuron Signaling Metencephalon Development Regulation Of Fat Cell Differentiation Cell-cell Signaling Signaling Response To Hormone Morphogenesis Of A Branching Epithelium Norrin Signaling Pathway Forebrain Anterior/posterior Pattern Specification Spemann Organizer Formation Glial Cell-neuron Signaling Midbrain-hindbrain Boundary Development Cell Communication Morphogenesis Of A Branching Structure Anterior/posterior Pattern Specification Mesodermal Cell Migration Apoptotic Process Involved In Blood Vessel Morphogenesis Negative Regulation Of Cell Differentiation Extracellular Matrix-cell Signaling Cell Proliferation In Midbrain Retinal Blood Vessel Morphogenesis Establishment Of Blood-retinal Barrier Chemorepulsion Of Axon