LRP5 and WNT1

Number of citations of the paper that reports this interaction (PubMedID 11336703)
0

Data Source:
HPRD (in vitro)

		LRP5	WNT1
Description		LDL receptor related protein 5	Wnt family member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Membrane Receptor Complex Wnt-Frizzled-LRP5/6 Complex Wnt Signalosome	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Extracellular Exosome
	Molecular Function	Protein Binding Coreceptor Activity Wnt-protein Binding Toxin Transmembrane Transporter Activity Wnt Receptor Activity	Signaling Receptor Binding Frizzled Binding Cytokine Activity Morphogen Activity Protein Domain Specific Binding Receptor Ligand Activity
	Biological Process	Gastrulation With Mouth Forming Second Vasculature Development Positive Regulation Of Mesenchymal Cell Proliferation Osteoblast Development Glucose Catabolic Process Amino Acid Transport Endocytosis Nervous System Development Mesodermal Cell Migration Cholesterol Metabolic Process Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Tissue Development Anterior/posterior Pattern Specification Gene Expression Wnt Signaling Pathway Osteoblast Proliferation Positive Regulation Of Osteoblast Proliferation Somatic Stem Cell Population Maintenance Limb Morphogenesis Extracellular Matrix-cell Signaling Cell Migration Involved In Gastrulation Cholesterol Homeostasis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Response To Peptide Hormone Small Molecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Fat Cell Differentiation Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Bone Remodeling Blood Vessel Morphogenesis Bone Marrow Development Anatomical Structure Regression Retina Morphogenesis In Camera-type Eye Canonical Wnt Signaling Pathway Bone Development Bone Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Duct Morphogenesis Adipose Tissue Development Cell-cell Signaling Involved In Mammary Gland Development Establishment Of Blood-brain Barrier Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Retina Vasculature Development In Camera-type Eye Retina Vasculature Morphogenesis In Camera-type Eye Retinal Blood Vessel Morphogenesis Regulation Of Biological Quality Cell-cell Adhesion Norrin Signaling Pathway Apoptotic Process Involved In Blood Vessel Morphogenesis Establishment Of Blood-retinal Barrier	Embryonic Axis Specification Branching Involved In Ureteric Bud Morphogenesis Cell-cell Signaling Myoblast Fusion Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Wounding Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Cell-substrate Adhesion Myotube Differentiation Wnt Signaling Pathway Spinal Cord Association Neuron Differentiation Diencephalon Development Cerebellum Development Central Nervous System Morphogenesis Cerebellum Formation Forebrain Anterior/posterior Pattern Specification Midbrain-hindbrain Boundary Maturation During Brain Development Neurogenesis Metencephalon Development Negative Regulation Of Cell-cell Adhesion Neuron Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Midbrain Development Midbrain-hindbrain Boundary Development Animal Organ Regeneration T Cell Differentiation In Thymus Cell Proliferation In Midbrain Astrocyte-dopaminergic Neuron Signaling Inner Ear Morphogenesis Signal Transduction In Response To DNA Damage Negative Regulation Of Apoptotic Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Neuron Fate Commitment Neuron Fate Determination Spemann Organizer Formation Canonical Wnt Signaling Pathway Bone Development Positive Regulation Of Dermatome Development Hepatocyte Differentiation Cellular Response To Peptide Hormone Stimulus Hematopoietic Stem Cell Proliferation Dopaminergic Neuron Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Embryonic Brain Development Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Senescence
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination Signaling by LRP5 mutants Signaling by RNF43 mutants	TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Transcriptional regulation of white adipocyte differentiation PCP/CE pathway PCP/CE pathway Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND) Sclerosing bone dysplasias, including: Endosteal hyperostosis; Van Buchem disease, type 2; Osteopetrosis, autosomal dominant 1 (OPTA1) Osteoporosis-pseudoglioma syndrome (OPPG)
GWAS		Bone mineral density ( 18455228 24249740) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 28743860) Bone mineral density (spine) ( 19801982) Femoral neck bone mineral density ( 29499414) Femoral neck section modulus ( 30888730) Fractures ( 30158200) Heel bone mineral density ( 28869591 30598549) Hip index ( 34021172) Lumbar spine bone mineral density ( 22504420 29499414) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Monobrow ( 27182965)	Bipolar disorder ( 31043756) Heel bone mineral density ( 28869591 30598549)
Interacting Genes		9 interacting genes: AXIN1 CAPRIN2 DKK1 FZD8 MESD MTDH SMAD9 THBS1 WNT1	9 interacting genes: FZD8 FZD9 LRP5 LRP6 PORCN RYK SFRP1 SFRP2 WNT3A
Entrez ID		4041	7471
HPRD ID		04616	01276
Ensembl ID		ENSG00000162337	ENSG00000125084
Uniprot IDs		O75197	P04628
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Canonical Wnt Signaling Pathway Negative Regulation Of CGMP-mediated Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Axis Specification Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Regulation Of CGMP-mediated Signaling Regulation Of Cellular Response To Growth Factor Stimulus Dorsal/ventral Axis Specification Regulation Of Wnt Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process I-SMAD Binding Negative Regulation Of Cellular Response To Growth Factor Stimulus Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Metabolic Process Heart Valve Development Regulation Of Cell Communication Regulation Of Signaling Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Macromolecule Biosynthetic Process Developmental Process CGMP-mediated Signaling Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Protein Metabolic Process T Cell Differentiation In Thymus Mesoderm Formation Regulation Of Intracellular Signal Transduction Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Developmental Process Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Negative Regulation Of Fat Cell Differentiation Formation Of Primary Germ Layer Beta-catenin Destruction Complex Assembly Mesoderm Development Positive Regulation Of Midbrain Dopaminergic Neuron Differentiation	Wnt-protein Binding Canonical Wnt Signaling Pathway Wnt Signaling Pathway Wnt-Frizzled-LRP5/6 Complex Wnt Receptor Activity Non-canonical Wnt Signaling Pathway Frizzled Binding Dopaminergic Neuron Differentiation Regulation Of Dopaminergic Neuron Differentiation Cell Surface Receptor Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Neuron Differentiation Regulation Of Fat Cell Differentiation Wnt Signaling Pathway Involved In Somitogenesis Regulation Of Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Wnt Signaling Pathway Anterior/posterior Pattern Specification Negative Regulation Of Cell Growth Somitogenesis Development Of Primary Male Sexual Characteristics Positive Regulation Of Neural Precursor Cell Proliferation Segmentation Positive Regulation Of Cell Population Proliferation Coreceptor Activity Convergent Extension Involved In Axis Elongation Negative Regulation Of Growth Toxin Transmembrane Transporter Activity Regulation Of Establishment Of Planar Polarity Positive Regulation Of Fat Cell Differentiation Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Axon Extension Involved In Axon Guidance Development Of Primary Sexual Characteristics Regulation Of Mesodermal Cell Differentiation Regionalization Regulation Of Animal Organ Morphogenesis Cellular Response To X-ray Tube Morphogenesis Regulation Of Neural Precursor Cell Proliferation Cellular Developmental Process Negative Regulation Of Cell Differentiation Wnt Signalosome Regulation Of Wnt Signaling Pathway Convergent Extension Morphogenesis Of An Epithelium Tissue Development Signal Transduction Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Locomotion Anatomical Structure Formation Involved In Morphogenesis
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