LDLR and PF4

Number of citations of the paper that reports this interaction (PubMedID 11986215)
0

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		LDLR	PF4
Description		low density lipoprotein receptor	platelet factor 4
Image
GO Annotations	Cellular Component	Lysosome Endosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Low-density Lipoprotein Particle Endolysosome Membrane Somatodendritic Compartment Receptor Complex Apical Part Of Cell Sorting Endosome PCSK9-LDLR Complex	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Platelet Alpha Granule Lumen
	Molecular Function	Amyloid-beta Binding Virus Receptor Activity Protease Binding Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Very-low-density Lipoprotein Particle Receptor Activity Clathrin Heavy Chain Binding Identical Protein Binding Molecular Adaptor Activity Lipoprotein Particle Binding	Cytokine Activity Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding Receptor Ligand Activity CXCR3 Chemokine Receptor Binding
	Biological Process	Retinoid Metabolic Process Negative Regulation Of Receptor Recycling Lipid Metabolic Process Lipid Transport Endocytosis Receptor-mediated Endocytosis Phagocytosis Long-term Memory Steroid Metabolic Process Cholesterol Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Phosphatidylcholine Catabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Phospholipid Transport Intestinal Cholesterol Absorption Cholesterol Transport Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance High-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Symbiont Entry Into Host Cell Artery Morphogenesis Positive Regulation Of Inflammatory Response Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Artery Development Response To Caloric Restriction Negative Regulation Of Astrocyte Activation Cholesterol Import Cellular Response To Fatty Acid Cellular Response To Low-density Lipoprotein Particle Stimulus Receptor-mediated Endocytosis Involved In Cholesterol Transport Regulation Of Cholesterol Metabolic Process Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Negative Regulation Of Microglial Cell Activation Positive Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Amyloid Fibril Formation	Monocyte Chemotaxis Chemotaxis Defense Response Inflammatory Response Immune Response Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Platelet Activation Negative Regulation Of Blood Coagulation Neutrophil Chemotaxis Leukocyte Chemotaxis Killing Of Cells Of Another Organism Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Defense Response To Protozoan Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Macrophage Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance Chylomicron clearance LDL clearance Retinoid metabolism and transport	Platelet degranulation Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall Chemokine receptors bind chemokines G alpha (i) signalling events RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs		Porfimer sodium	Drotrecogin alfa Heparin
Diseases		Hypercholesterolemia, autosomal dominant; Hyperlipoproteinemia, type IIa
GWAS		Abdominal aortic aneurysm ( 27899403 24046328) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Apolipoprotein B levels ( 32203549) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness ( 21909108) Carotid plaque ( 30510157) Cholesterol ( 31902109) Cholesterol, total ( 20686565 24097068 26582766 19060911 25961943) Coronary artery disease ( 32469254 26343387 24262325 33020668 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Cortisol levels (saliva) ( 28843169) Disorders of lipid metabolism ( 30166351) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol ( 26582766 30275531 18193044 24097068 23726366 25961943 21347282 20864672 20686565 19060906 18193043 19060910 19060911) LDL cholesterol levels ( 32203549 26690388 30698716 28334899) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222 22286219) Lipoprotein (a) levels ( 33730874) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152) Low density lipoprotein cholesterol levels ( 30911093 33339817 31217584 29403010) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antithrombotic agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Medication use (salicylic acid and derivatives) ( 31015401) Metabolite levels ( 21909109 22916037 23823483) Myocardial infarction ( 33532862 26343387) Myocardial infarction (early onset) ( 19198609) Parental lifespan ( 30642433) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Peripheral artery disease ( 31285632) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 28334899 31217584 30911093 33339817 29403010)	Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		18 interacting genes: AP1M2 APOB APOE CD36 CREBBP DAB1 DAB2 HSPA5 LDLRAP1 LRPAP1 MAP4 MTIF3 MYLIP PCSK9 PF4 SNX17 TLE5 WEE2-AS1	29 interacting genes: CCL11 CCL13 CCL2 CCL20 CCL21 CCL25 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL6 CXCL8 CXCL9 CXCR3 FGF2 LDLR PROC SDC2 SNCA SRGN THBD VCAN XCL1 XCL2
Entrez ID		3949	5196
HPRD ID		06091	01426
Ensembl ID		ENSG00000130164	ENSG00000163737
Uniprot IDs		H0YMQ3 P01130	P02776
PDB IDs		1AJJ 1D2J 1F5Y 1F8Z 1HJ7 1HZ8 1I0U 1IJQ 1LDL 1LDR 1N7D 1XFE 2FCW 2KRI 2LGP 2M7P 2MG9 2W2M 2W2N 2W2O 2W2P 2W2Q 3BPS 3GCW 3GCX 3M0C 3P5B 3P5C 3SO6 4NE9 5OY9 5OYL 9BD8 9BDE 9BDT 9COO	1DN3 1F9Q 1F9R 1F9S 1PFM 1PFN 1RHP 4R9W 4R9Y 4RAU
Enriched GO Terms of Interacting Partners?		Low-density Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding Plasma Lipoprotein Particle Clearance Regulation Of Endocytosis Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Sterol Homeostasis Cholesterol Homeostasis Cholesterol Metabolic Process Sterol Metabolic Process Negative Regulation Of Cellular Component Organization Low-density Lipoprotein Particle Clearance Positive Regulation Of Endocytosis Cholesterol Transport Lipid Homeostasis Negative Regulation Of Lipoprotein Particle Clearance Receptor-mediated Endocytosis Regulation Of Vesicle-mediated Transport Clathrin Adaptor Activity Negative Regulation Of Cell Projection Organization Regulation Of Low-density Lipoprotein Particle Clearance Chylomicron Remnant Cerebellum Structural Organization Positive Regulation Of Macrophage Derived Foam Cell Differentiation Sterol Transport Amyloid-beta Binding Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Steroid Metabolic Process Regulation Of Steroid Metabolic Process Lipoprotein Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cellular Component Organization Negative Regulation Of Neuron Projection Development Regulation Of Receptor-mediated Endocytosis Cellular Response To Lipoprotein Particle Stimulus Alcohol Metabolic Process Receptor Ligand Activity Intermediate-density Lipoprotein Particle Positive Regulation Of Steroid Metabolic Process Regulation Of Lipid Transport Intracellular Membrane-bounded Organelle Lipoprotein Biosynthetic Process Early Endosome Regulation Of Cholesterol Metabolic Process Heparin Binding Cellular Response To Amyloid-beta Organic Hydroxy Compound Transport Positive Regulation Of Cholesterol Storage Positive Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Binding Positive Regulation Of Amyloid-beta Clearance	Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Chemotaxis Chemotaxis Antimicrobial Humoral Response Cytokine Activity Locomotion Leukocyte Chemotaxis Chemokine-mediated Signaling Pathway Humoral Immune Response Leukocyte Migration Cell Migration Extracellular Space Cell Motility Granulocyte Chemotaxis Killing Of Cells Of Another Organism Granulocyte Migration Myeloid Leukocyte Migration Cell Killing Inflammatory Response CCR Chemokine Receptor Binding Defense Response To Symbiont Extracellular Region Defense Response To Other Organism Response To External Biotic Stimulus Mononuclear Cell Migration Cytokine-mediated Signaling Pathway Immune Response Positive Regulation Of Locomotion Response To Other Organism Positive Regulation Of Chemotaxis Defense Response Immune System Process Regulation Of Leukocyte Migration Eosinophil Chemotaxis Positive Regulation Of Cell Migration Eosinophil Migration Chemokine Receptor Binding Regulation Of Locomotion Positive Regulation Of Cell Motility G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Chemotaxis CXCR Chemokine Receptor Binding Lymphocyte Migration Regulation Of Cell Motility Positive Regulation Of Calcium Ion Transport T Cell Migration Response To Stress Lymphocyte Chemotaxis
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