PF4 and CCL20

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down)

		PF4	CCL20
Description		platelet factor 4	C-C motif chemokine ligand 20
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Platelet Alpha Granule Lumen	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding Receptor Ligand Activity CXCR3 Chemokine Receptor Binding	Cytokine Activity Protein Binding Chemokine Activity CCR6 Chemokine Receptor Binding
	Biological Process	Monocyte Chemotaxis Chemotaxis Defense Response Inflammatory Response Immune Response Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Platelet Activation Negative Regulation Of Blood Coagulation Neutrophil Chemotaxis Leukocyte Chemotaxis Killing Of Cells Of Another Organism Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Defense Response To Protozoan Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Macrophage Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Calcium-mediated Signaling Killing Of Cells Of Another Organism Defense Response To Bacterium Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide T Cell Migration Thymocyte Migration Positive Regulation Of T Cell Migration
Pathways		Platelet degranulation Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall Chemokine receptors bind chemokines G alpha (i) signalling events RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs		Drotrecogin alfa Heparin
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 31959851 32296059 34103634) Asthma (childhood onset) ( 30929738 31036433) Asthma onset (childhood vs adult) ( 30929738) Blood pressure ( 17903302) Crohn's disease ( 26192919) Eating disorders (purging via substances) ( 23568457) Inflammatory bowel disease ( 26192919) Primary biliary cholangitis ( 26394269) Ulcerative colitis ( 26192919)
Interacting Genes		29 interacting genes: CCL11 CCL13 CCL2 CCL20 CCL21 CCL25 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL6 CXCL8 CXCL9 CXCR3 FGF2 LDLR PROC SDC2 SNCA SRGN THBD VCAN XCL1 XCL2	11 interacting genes: CCL5 CCR6 CXCL11 CXCL12 CXCL17 CXCL5 MTDH PF4 TGFB3 VCAN XCL2
Entrez ID		5196	6364
HPRD ID		01426	03571
Ensembl ID		ENSG00000163737	ENSG00000115009
Uniprot IDs		P02776	P78556
PDB IDs		1DN3 1F9Q 1F9R 1F9S 1PFM 1PFN 1RHP 4R9W 4R9Y 4RAU	1M8A 2HCI 2JYO 5UR7 6WWZ 7T1E
Enriched GO Terms of Interacting Partners?		Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Chemotaxis Chemotaxis Antimicrobial Humoral Response Cytokine Activity Locomotion Leukocyte Chemotaxis Chemokine-mediated Signaling Pathway Humoral Immune Response Leukocyte Migration Cell Migration Extracellular Space Cell Motility Granulocyte Chemotaxis Killing Of Cells Of Another Organism Granulocyte Migration Myeloid Leukocyte Migration Cell Killing Inflammatory Response CCR Chemokine Receptor Binding Defense Response To Symbiont Extracellular Region Defense Response To Other Organism Response To External Biotic Stimulus Mononuclear Cell Migration Cytokine-mediated Signaling Pathway Immune Response Positive Regulation Of Locomotion Response To Other Organism Positive Regulation Of Chemotaxis Defense Response Immune System Process Regulation Of Leukocyte Migration Eosinophil Chemotaxis Positive Regulation Of Cell Migration Eosinophil Migration Chemokine Receptor Binding Regulation Of Locomotion Positive Regulation Of Cell Motility G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Chemotaxis CXCR Chemokine Receptor Binding Lymphocyte Migration Regulation Of Cell Motility Positive Regulation Of Calcium Ion Transport T Cell Migration Response To Stress Lymphocyte Chemotaxis	Cell Chemotaxis Chemokine Activity Leukocyte Chemotaxis Chemotaxis Locomotion Cytokine Activity Mononuclear Cell Migration Leukocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Humoral Immune Response Cell Migration Antimicrobial Humoral Response Cell Motility Chemokine-mediated Signaling Pathway Extracellular Space CXCR Chemokine Receptor Binding Cytokine-mediated Signaling Pathway Extracellular Region Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Monocyte Chemotaxis Myeloid Leukocyte Migration Regulation Of Monocyte Chemotaxis T Cell Migration Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Immune Response Immune System Process Defense Response To Symbiont Defense Response To Other Organism G Protein-coupled Receptor Signaling Pathway Regulation Of T Cell Migration CXCR3 Chemokine Receptor Binding Cell Surface Receptor Signaling Pathway Defense Response Lymphocyte Migration Regulation Of Chemotaxis Regulation Of Leukocyte Migration Regulation Of Lymphocyte Migration Inflammatory Response Granulocyte Chemotaxis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Chemokine Receptor Binding Positive Regulation Of Locomotion Granulocyte Migration Response To Other Organism Positive Regulation Of Calcium Ion Transport T Cell Chemotaxis
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