PF4 and CXCL12

Number of citations of the paper that reports this interaction (PMID 10233851)
66

Data Source:
BioGRID (pull down)

		PF4	CXCL12
Gene Name		platelet factor 4	chemokine (C-X-C motif) ligand 12
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen	Extracellular Region Extracellular Space External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Chemokine Activity Heparin Binding CXCR3 Chemokine Receptor Binding	Receptor Binding Chemokine Activity Growth Factor Activity Chemokine Receptor Binding CXCR Chemokine Receptor Binding
	Biological Process	Platelet Degranulation Positive Regulation Of Leukocyte Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Blood Coagulation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Platelet Activation Leukocyte Chemotaxis Positive Regulation Of CAMP Metabolic Process Response To Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Proliferation Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Macrophage Differentiation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Cytolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Chemokine-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Patterning Of Blood Vessels Response To Hypoxia Ameboidal-type Cell Migration Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Cellular Calcium Ion Homeostasis Chemotaxis Immune Response Cell Adhesion Signal Transduction G-protein Coupled Receptor Signaling Pathway Germ Cell Development Blood Circulation Motor Neuron Axon Guidance Regulation Of Actin Polymerization Or Depolymerization Adult Locomotory Behavior Germ Cell Migration Response To Radiation Response To Heat Response To Mechanical Stimulus Response To Virus Telencephalon Cell Migration Organ Regeneration Positive Regulation Of Dopamine Secretion T Cell Proliferation Response To Peptide Hormone Positive Regulation Of Cell Adhesion Positive Regulation Of Axon Extension Involved In Axon Guidance Induction Of Positive Chemotaxis Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Calcium Ion Import Positive Regulation Of Myoblast Fusion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Leukocyte Tethering Or Rolling Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of T Cell Migration
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Platelet degranulation GPCR ligand binding Metabolic disorders of biological oxidation enzymes Formation of Fibrin Clot (Clotting Cascade) Cell surface interactions at the vascular wall Common Pathway GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Response to elevated platelet cytosolic Ca2+ G alpha (i) signalling events Platelet activation, signaling and aggregation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Signaling by ERBB4 GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling Nuclear signaling by ERBB4 Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Drotrecogin alfa	Tinzaparin
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037)	Coronary heart disease ( 17634449 21378990) Myocardial infarction (early onset) ( 19198609) Schizophrenia ( 23212062)
Protein-Protein Interactions		11 interactors: CCL5 CXCL12 CXCL8 CXCR3 FGF2 LDLR PROC SDC2 SRGN THBD VCAN	10 interactors: CD4 CTSG CXCR4 DAZAP2 DPP4 ELANE FN1 MMP2 PF4 VCAN
Entrez ID		5196	6387
HPRD ID		01426	02904
Ensembl ID			ENSG00000107562
Uniprot IDs		P02776	H7BYN8 P48061
PDB IDs		1DN3 1F9Q 1F9R 1F9S 1PFM 1PFN 1RHP	1A15 1QG7 1SDF 1VMC 2J7Z 2K01 2K03 2K04 2K05 2KEC 2KED 2KEE 2KOL 2NWG 2SDF 3GV3 3HP3 4LMQ
Enriched GO Terms of Interacting Partners?		Locomotion Cell Migration Cell Motility Movement Of Cell Or Subcellular Component Positive Regulation Of Chemotaxis Positive Regulation Of Behavior Regulation Of Chemotaxis Chemokine-mediated Signaling Pathway Regulation Of Behavior Leukocyte Migration Chemotaxis Response To External Stimulus Regulation Of Leukocyte Migration Positive Regulation Of Locomotion Cell Chemotaxis Response To Stress Glycosaminoglycan Catabolic Process Negative Regulation Of Wound Healing Positive Regulation Of Leukocyte Chemotaxis Regulation Of Cell Migration Wound Healing Regulation Of Cell Motility Regulation Of Epithelial Cell Proliferation Cellular Calcium Ion Homeostasis Regulation Of Endothelial Cell Proliferation Regulation Of Locomotion Positive Regulation Of Leukocyte Migration Calcium Ion Homeostasis Regulation Of Cellular Component Movement Response To Wounding Positive Regulation Of Calcium Ion Transport Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Cell Migration Angiogenesis Positive Regulation Of Cell Motility Immune System Process Leukocyte Chemotaxis Positive Regulation Of Cellular Component Movement Regulation Of Monocyte Chemotaxis Chemical Homeostasis Regulation Of Wound Healing Cardiovascular System Development Cellular Metal Ion Homeostasis Induction Of Positive Chemotaxis Blood Vessel Morphogenesis Positive Regulation Of T Cell Migration Response To Organic Substance Cellular Cation Homeostasis Response To Radiation Cytokine-mediated Signaling Pathway	Locomotion Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Movement Of Cell Or Subcellular Component Cell Migration Positive Regulation Of Immune System Process Cell Motility Leukocyte Migration Response To Stress Immune System Process Regulation Of Immune System Process Cell Activation Defense Response Response To Other Organism Killing By Host Of Symbiont Cells Response To Biotic Stimulus Inflammatory Response Response To External Stimulus Regulation Of Chemotaxis Response To Bacterium Neutrophil Mediated Immunity Cell Adhesion Killing Of Cells Of Other Organism Regulation Of Behavior Defense Response To Bacterium Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Positive Regulation Of Immune Response Interaction With Symbiont Leukocyte Mediated Cytotoxicity Endodermal Cell Differentiation Response To Fungus Entry Into Host Cell T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Positive Regulation Of Intracellular Signal Transduction Response To Hypoxia Response To Lipopolysaccharide Leukocyte Cell-cell Adhesion Endoderm Formation Regulation Of Immune Response Cardiovascular System Development Homotypic Cell-cell Adhesion Angiogenesis Response To Molecule Of Bacterial Origin Chemokine-mediated Signaling Pathway Collagen Catabolic Process
Tagcloud ?		10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4v1 phylogenetic physically ppbp primers scyb5 sdf1 separated	adam23 adenomatous apc bc bcs cumulative detecting disintegrin hypermethylation informative invasiveness lnms maintaining manifested metalloprotease methylated methylation methylations pl polyposis pts pyrosequencing quantification quantify rassf1a software spectrums spss utility
Tagcloud (Difference) ?		10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4v1 phylogenetic physically ppbp primers scyb5 sdf1 separated	adam23 adenomatous apc bc bcs cumulative detecting disintegrin hypermethylation informative invasiveness lnms maintaining manifested metalloprotease methylated methylation methylations pl polyposis pts pyrosequencing quantification quantify rassf1a software spectrums spss utility
Tagcloud (Intersection) ?