PF4 and THBD

Number of citations of the paper that reports this interaction (PMID 9395524)
4

Data Source:
HPRD (in vitro)

		PF4	THBD
Gene Name		platelet factor 4	thrombomodulin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Chemokine Activity Heparin Binding CXCR3 Chemokine Receptor Binding	Receptor Activity Transmembrane Signaling Receptor Activity Calcium Ion Binding Protein Binding
	Biological Process	Platelet Degranulation Positive Regulation Of Leukocyte Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Blood Coagulation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Platelet Activation Leukocyte Chemotaxis Positive Regulation Of CAMP Metabolic Process Response To Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Proliferation Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Macrophage Differentiation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Cytolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Chemokine-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Signal Transduction Female Pregnancy Blood Coagulation Response To X-ray Negative Regulation Of Platelet Activation Negative Regulation Of Blood Coagulation Response To Lipopolysaccharide Leukocyte Migration Response To CAMP Negative Regulation Of Fibrinolysis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Platelet degranulation GPCR ligand binding Metabolic disorders of biological oxidation enzymes Formation of Fibrin Clot (Clotting Cascade) Cell surface interactions at the vascular wall Common Pathway GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Response to elevated platelet cytosolic Ca2+ G alpha (i) signalling events Platelet activation, signaling and aggregation	Common Pathway Formation of Fibrin Clot (Clotting Cascade) Cell surface interactions at the vascular wall
Drugs		Drotrecogin alfa	Drotrecogin alfa Ibuprofen
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037)
Protein-Protein Interactions		11 interactors: CCL5 CXCL12 CXCL8 CXCR3 FGF2 LDLR PROC SDC2 SRGN THBD VCAN	5 interactors: F2 PF4 PROC PSENEN SERPINA5
Entrez ID		5196	7056
HPRD ID		01426	01764
Ensembl ID			ENSG00000178726
Uniprot IDs		P02776	P07204
PDB IDs		1DN3 1F9Q 1F9R 1F9S 1PFM 1PFN 1RHP	1ADX 1DQB 1DX5 1EGT 1FGD 1FGE 1HLT 1TMR 1ZAQ 2ADX 3GIS
Enriched GO Terms of Interacting Partners?		Locomotion Cell Migration Cell Motility Movement Of Cell Or Subcellular Component Positive Regulation Of Chemotaxis Positive Regulation Of Behavior Regulation Of Chemotaxis Chemokine-mediated Signaling Pathway Regulation Of Behavior Leukocyte Migration Chemotaxis Response To External Stimulus Regulation Of Leukocyte Migration Positive Regulation Of Locomotion Cell Chemotaxis Response To Stress Glycosaminoglycan Catabolic Process Negative Regulation Of Wound Healing Positive Regulation Of Leukocyte Chemotaxis Regulation Of Cell Migration Wound Healing Regulation Of Cell Motility Regulation Of Epithelial Cell Proliferation Cellular Calcium Ion Homeostasis Regulation Of Endothelial Cell Proliferation Regulation Of Locomotion Positive Regulation Of Leukocyte Migration Calcium Ion Homeostasis Regulation Of Cellular Component Movement Response To Wounding Positive Regulation Of Calcium Ion Transport Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Cell Migration Angiogenesis Positive Regulation Of Cell Motility Immune System Process Leukocyte Chemotaxis Positive Regulation Of Cellular Component Movement Regulation Of Monocyte Chemotaxis Chemical Homeostasis Regulation Of Wound Healing Cardiovascular System Development Cellular Metal Ion Homeostasis Induction Of Positive Chemotaxis Blood Vessel Morphogenesis Positive Regulation Of T Cell Migration Response To Organic Substance Cellular Cation Homeostasis Response To Radiation Cytokine-mediated Signaling Pathway	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Peptidyl-glutamic Acid Carboxylation Response To Wounding Leukocyte Migration Locomotion Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Movement Of Cell Or Subcellular Component Regulation Of Blood Coagulation Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Wound Healing Cell Migration Cell Motility Negative Regulation Of Cytolysis Platelet Activation Post-translational Protein Modification Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Response To Stress Negative Regulation Of Fibrinolysis Negative Regulation Of Proteolysis Regulation Of Apoptotic Process Negative Regulation Of Protein Processing Proteolysis Positive Regulation Of Macrophage Differentiation Amyloid Precursor Protein Catabolic Process Regulation Of Cell Death Regulation Of Protein Processing Regulation Of Fibrinolysis Positive Regulation Of CAMP-mediated Signaling Inflammatory Response Blood Coagulation, Intrinsic Pathway Negative Regulation Of Astrocyte Differentiation Fusion Of Sperm To Egg Plasma Membrane Membrane Protein Intracellular Domain Proteolysis Negative Regulation Of Platelet Activation Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Megakaryocyte Differentiation Plasma Membrane Fusion Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Regulation Of CAMP-mediated Signaling Notch Receptor Processing Response To Stimulus Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Tagcloud ?		10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4v1 phylogenetic physically ppbp primers scyb5 sdf1 separated	acat acyltransferase alox5ap arachidonate ath atherosclerotic cbs cysthathionenine deceased gathered genomelab gexp hcats irs1 lcat ldlr lecithin lipoxygenase lpl malaysian metallopeptidase methylenetetrahydrofolate mmp9 mortem mthfr ncat predetermined tgfbr2 thrombomodulin
Tagcloud (Difference) ?		10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4v1 phylogenetic physically ppbp primers scyb5 sdf1 separated	acat acyltransferase alox5ap arachidonate ath atherosclerotic cbs cysthathionenine deceased gathered genomelab gexp hcats irs1 lcat ldlr lecithin lipoxygenase lpl malaysian metallopeptidase methylenetetrahydrofolate mmp9 mortem mthfr ncat predetermined tgfbr2 thrombomodulin
Tagcloud (Intersection) ?