PF4 and CXCL8

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		PF4	CXCL8
Description		platelet factor 4	C-X-C motif chemokine ligand 8
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Platelet Alpha Granule Lumen	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding Receptor Ligand Activity CXCR3 Chemokine Receptor Binding	Cytokine Activity Interleukin-8 Receptor Binding Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding
	Biological Process	Monocyte Chemotaxis Chemotaxis Defense Response Inflammatory Response Immune Response Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Platelet Activation Negative Regulation Of Blood Coagulation Neutrophil Chemotaxis Leukocyte Chemotaxis Killing Of Cells Of Another Organism Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Defense Response To Protozoan Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Macrophage Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Angiogenesis Response To Molecule Of Bacterial Origin Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-mediated Signaling Regulation Of Cell Adhesion Neutrophil Chemotaxis Receptor Internalization Killing Of Cells Of Another Organism Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Neutrophil Activation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiogenesis Embryonic Digestive Tract Development Induction Of Positive Chemotaxis Negative Regulation Of Cell Adhesion Molecule Production Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis Regulation Of Entry Of Bacterium Into Host Cell
Pathways		Platelet degranulation Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall Chemokine receptors bind chemokines G alpha (i) signalling events RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Senescence-Associated Secretory Phenotype (SASP) Peptide ligand-binding receptors Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress G alpha (i) signalling events Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling
Drugs		Drotrecogin alfa Heparin	ABT-510 MDX-018 Rivanicline Oleandrin
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)	Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566)
Interacting Genes		29 interacting genes: CCL11 CCL13 CCL2 CCL20 CCL21 CCL25 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL6 CXCL8 CXCL9 CXCR3 FGF2 LDLR PROC SDC2 SNCA SRGN THBD VCAN XCL1 XCL2	23 interacting genes: ACKR1 ARFGAP3 BAG6 CCL2 CCL4 CCL5 CCL8 CTSL CXCR1 CXCR2 EP300 ERBB2 GNAI2 IL12A MMP14 MMP9 PF4 POMGNT1 SDC1 SGTA WASF1 ZFP36 ZNF598
Entrez ID		5196	3576
HPRD ID		01426	00909
Ensembl ID		ENSG00000163737	ENSG00000169429
Uniprot IDs		P02776	C9J4T6 P10145
PDB IDs		1DN3 1F9Q 1F9R 1F9S 1PFM 1PFN 1RHP 4R9W 4R9Y 4RAU	1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8 4XDX 5D14 5WDZ 6LFM 6LFO 6N2U 6WZM 6XMN 8IC0 8XWN 8XX6
Enriched GO Terms of Interacting Partners?		Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Chemotaxis Chemotaxis Antimicrobial Humoral Response Cytokine Activity Locomotion Leukocyte Chemotaxis Chemokine-mediated Signaling Pathway Humoral Immune Response Leukocyte Migration Cell Migration Extracellular Space Cell Motility Granulocyte Chemotaxis Killing Of Cells Of Another Organism Granulocyte Migration Myeloid Leukocyte Migration Cell Killing Inflammatory Response CCR Chemokine Receptor Binding Defense Response To Symbiont Extracellular Region Defense Response To Other Organism Response To External Biotic Stimulus Mononuclear Cell Migration Cytokine-mediated Signaling Pathway Immune Response Positive Regulation Of Locomotion Response To Other Organism Positive Regulation Of Chemotaxis Defense Response Immune System Process Regulation Of Leukocyte Migration Eosinophil Chemotaxis Positive Regulation Of Cell Migration Eosinophil Migration Chemokine Receptor Binding Regulation Of Locomotion Positive Regulation Of Cell Motility G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Chemotaxis CXCR Chemokine Receptor Binding Lymphocyte Migration Regulation Of Cell Motility Positive Regulation Of Calcium Ion Transport T Cell Migration Response To Stress Lymphocyte Chemotaxis	Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Granulocyte Migration Cell Surface Receptor Signaling Pathway Myeloid Leukocyte Migration Leukocyte Chemotaxis Cytokine-mediated Signaling Pathway Cell Migration Chemokine Activity Cell Chemotaxis Locomotion Eosinophil Chemotaxis Leukocyte Migration Eosinophil Migration C-C Chemokine Binding Cell Motility Positive Regulation Of Leukocyte Migration CCR Chemokine Receptor Binding Signal Transduction Chemotaxis Positive Regulation Of Mononuclear Cell Migration Inflammatory Response Mononuclear Cell Migration Cytokine Activity G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Leukocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Response To Stress Immune System Process Regulation Of Mononuclear Cell Migration Dendritic Cell Chemotaxis Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Regulation Of Immune System Process Antimicrobial Humoral Response Receptor-mediated Endocytosis Host-mediated Perturbation Of Viral Process Positive Regulation Of Immune System Process Monocyte Chemotaxis Defense Response Dendritic Cell Migration Regulation Of Lymphocyte Chemotaxis Interleukin-8 Binding Positive Regulation Of Macrophage Migration Regulation Of Apoptotic Process Positive Regulation Of Leukocyte Chemotaxis Host-mediated Perturbation Of Viral Transcription
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