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PF4 and CXCL8
Number of citations of the paper that reports this interaction (PMID
15531763
)
14
Data Source:
HPRD
(in vitro, in vivo)
PF4
CXCL8
Gene Name
platelet factor 4
chemokine (C-X-C motif) ligand 8
Image
Gene Ontology Annotations
Cellular Component
Extracellular Region
Extracellular Space
Platelet Alpha Granule Lumen
Extracellular Region
Extracellular Space
Molecular Function
Chemokine Activity
Heparin Binding
CXCR3 Chemokine Receptor Binding
Interleukin-8 Receptor Binding
Protein Binding
Chemokine Activity
Biological Process
Platelet Degranulation
Positive Regulation Of Leukocyte Chemotaxis
Inflammatory Response
Immune Response
G-protein Coupled Receptor Signaling Pathway
Blood Coagulation
Positive Regulation Of Gene Expression
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Platelet Activation
Leukocyte Chemotaxis
Positive Regulation Of CAMP Metabolic Process
Response To Lipopolysaccharide
Positive Regulation Of Tumor Necrosis Factor Production
Regulation Of Cell Proliferation
Positive Regulation Of CAMP-mediated Signaling
Negative Regulation Of MHC Class II Biosynthetic Process
Positive Regulation Of Macrophage Differentiation
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Cytolysis
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Chemokine-mediated Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Angiogenesis
Response To Molecule Of Bacterial Origin
Movement Of Cell Or Subcellular Component
Chemotaxis
Inflammatory Response
Immune Response
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Cell Cycle Arrest
Signal Transduction
G-protein Coupled Receptor Signaling Pathway
Negative Regulation Of Cell Proliferation
Calcium-mediated Signaling
Regulation Of Cell Adhesion
Neutrophil Chemotaxis
Endoplasmic Reticulum Unfolded Protein Response
Receptor Internalization
Response To Endoplasmic Reticulum Stress
Intracellular Signal Transduction
Neutrophil Activation
Cellular Protein Metabolic Process
Cellular Response To Fibroblast Growth Factor Stimulus
Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Embryonic Digestive Tract Development
Induction Of Positive Chemotaxis
Chemokine-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Neutrophil Chemotaxis
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
Class A/1 (Rhodopsin-like receptors)
Platelet degranulation
GPCR ligand binding
Metabolic disorders of biological oxidation enzymes
Formation of Fibrin Clot (Clotting Cascade)
Cell surface interactions at the vascular wall
Common Pathway
GPCR downstream signaling
Peptide ligand-binding receptors
Chemokine receptors bind chemokines
Response to elevated platelet cytosolic Ca2+
G alpha (i) signalling events
Platelet activation, signaling and aggregation
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
Class A/1 (Rhodopsin-like receptors)
Cellular Senescence
ATF4 activates genes
Senescence-Associated Secretory Phenotype (SASP)
GPCR ligand binding
Metabolic disorders of biological oxidation enzymes
GPCR downstream signaling
Peptide ligand-binding receptors
Chemokine receptors bind chemokines
G alpha (i) signalling events
PERK regulates gene expression
Unfolded Protein Response (UPR)
Drugs
Drotrecogin alfa
Diseases
GWAS
Inflammatory bowel disease (
23128233
)
Metabolite levels (
22916037
)
Protein-Protein Interactions
11 interactors:
CCL5
CXCL12
CXCL8
CXCR3
FGF2
LDLR
PROC
SDC2
SRGN
THBD
VCAN
18 interactors:
ACKR1
ARFGAP3
BAG6
CCL4
CCL5
CSNK2A1
CTSL
CXCR1
CXCR2
EP300
GNAI2
IL12A
MMP9
PF4
POMGNT1
SDC1
SGTA
WASF1
Entrez ID
5196
3576
HPRD ID
01426
00909
Ensembl ID
ENSG00000169429
Uniprot IDs
P02776
P10145
PDB IDs
1DN3
1F9Q
1F9R
1F9S
1PFM
1PFN
1RHP
1ICW
1IKL
1IKM
1IL8
1ILP
1ILQ
1QE6
1ROD
2IL8
3IL8
Enriched GO Terms of Interacting Partners
?
Locomotion
Cell Migration
Cell Motility
Movement Of Cell Or Subcellular Component
Positive Regulation Of Chemotaxis
Positive Regulation Of Behavior
Regulation Of Chemotaxis
Chemokine-mediated Signaling Pathway
Regulation Of Behavior
Leukocyte Migration
Chemotaxis
Response To External Stimulus
Regulation Of Leukocyte Migration
Positive Regulation Of Locomotion
Cell Chemotaxis
Response To Stress
Glycosaminoglycan Catabolic Process
Negative Regulation Of Wound Healing
Positive Regulation Of Leukocyte Chemotaxis
Regulation Of Cell Migration
Wound Healing
Regulation Of Cell Motility
Regulation Of Epithelial Cell Proliferation
Cellular Calcium Ion Homeostasis
Regulation Of Endothelial Cell Proliferation
Regulation Of Locomotion
Positive Regulation Of Leukocyte Migration
Calcium Ion Homeostasis
Regulation Of Cellular Component Movement
Response To Wounding
Positive Regulation Of Calcium Ion Transport
Positive Regulation Of Monocyte Chemotaxis
Positive Regulation Of Cell Migration
Angiogenesis
Positive Regulation Of Cell Motility
Immune System Process
Leukocyte Chemotaxis
Positive Regulation Of Cellular Component Movement
Regulation Of Monocyte Chemotaxis
Chemical Homeostasis
Regulation Of Wound Healing
Cardiovascular System Development
Cellular Metal Ion Homeostasis
Induction Of Positive Chemotaxis
Blood Vessel Morphogenesis
Positive Regulation Of T Cell Migration
Response To Organic Substance
Cellular Cation Homeostasis
Response To Radiation
Cytokine-mediated Signaling Pathway
Chemokine-mediated Signaling Pathway
Defense Response
Inflammatory Response
Signal Transduction
Cell Chemotaxis
Dendritic Cell Chemotaxis
Positive Regulation Of Leukocyte Chemotaxis
Chemotaxis
Signaling
Response To External Stimulus
Cell Communication
Movement Of Cell Or Subcellular Component
Positive Regulation Of Leukocyte Migration
Leukocyte Migration
Interleukin-8-mediated Signaling Pathway
Response To Stress
Immune System Process
Dendritic Cell Migration
Leukocyte Chemotaxis
Positive Regulation Of Chemotaxis
Regulation Of Leukocyte Migration
Cell Migration
Cellular Response To Stimulus
Locomotion
Interaction With Symbiont
Positive Regulation Of Behavior
Cell Motility
Cell Surface Receptor Signaling Pathway
Regulation Of Chemotaxis
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Cellular Component Movement
Positive Regulation Of Locomotion
Positive Regulation Of Natural Killer Cell Chemotaxis
Regulation Of Behavior
Cytokine-mediated Signaling Pathway
Regulation Of Viral Transcription
Immune Response
Response To Stimulus
Negative Regulation By Host Of Viral Transcription
Response To Organic Substance
Positive Regulation Of Immune System Process
Regulation Of Apoptotic Process
Cellular Response To Cytokine Stimulus
Regulation Of Cell Migration
Regulation Of Cell Proliferation
Negative Regulation Of Myeloid Cell Apoptotic Process
Regulation Of Cell Death
Regulation Of Cell Motility
Regulation Of Locomotion
Tagcloud
?
10q
4q
another
chemokine
constitutes
cr
cxc
divergent
evolutionary
gcp2
genbridge
gro1
gro2
gro3
il8
inp10
mapped
mentioned
mig
pair
panel
pf4v1
phylogenetic
physically
ppbp
primers
scyb5
sdf1
separated
Tagcloud (Difference)
?
10q
4q
another
chemokine
constitutes
cr
cxc
divergent
evolutionary
gcp2
genbridge
gro1
gro2
gro3
il8
inp10
mapped
mentioned
mig
pair
panel
pf4v1
phylogenetic
physically
ppbp
primers
scyb5
sdf1
separated
Tagcloud (Intersection)
?