PF4 and CXCL14

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down, pull down)

		PF4	CXCL14
Description		platelet factor 4	C-X-C motif chemokine ligand 14
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Platelet Alpha Granule Lumen	Extracellular Region Extracellular Space Golgi Apparatus
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding Receptor Ligand Activity CXCR3 Chemokine Receptor Binding	Cytokine Activity Protein Binding Chemokine Activity
	Biological Process	Monocyte Chemotaxis Chemotaxis Defense Response Inflammatory Response Immune Response Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Platelet Activation Negative Regulation Of Blood Coagulation Neutrophil Chemotaxis Leukocyte Chemotaxis Killing Of Cells Of Another Organism Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Defense Response To Protozoan Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Macrophage Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Chemotaxis Immune Response Signal Transduction Cell-cell Signaling Killing Of Cells Of Another Organism Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Platelet degranulation Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall Chemokine receptors bind chemokines G alpha (i) signalling events RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs		Drotrecogin alfa Heparin
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)	Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321)
Interacting Genes		29 interacting genes: CCL11 CCL13 CCL2 CCL20 CCL21 CCL25 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL6 CXCL8 CXCL9 CXCR3 FGF2 LDLR PROC SDC2 SNCA SRGN THBD VCAN XCL1 XCL2	28 interacting genes: APP CCL11 CCL13 CCL21 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL17 CXCL2 CXCL5 CXCL9 F2R GPR85 JMJD6 KLRC1 LMNA PF4 PPBP REL ROBO3 SLAMF6 TEX11 TNFRSF10C TRIM23 XCL1
Entrez ID		5196	9547
HPRD ID		01426	16049
Ensembl ID		ENSG00000163737	ENSG00000145824
Uniprot IDs		P02776	O95715
PDB IDs		1DN3 1F9Q 1F9R 1F9S 1PFM 1PFN 1RHP 4R9W 4R9Y 4RAU	2HDL
Enriched GO Terms of Interacting Partners?		Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Chemotaxis Chemotaxis Antimicrobial Humoral Response Cytokine Activity Locomotion Leukocyte Chemotaxis Chemokine-mediated Signaling Pathway Humoral Immune Response Leukocyte Migration Cell Migration Extracellular Space Cell Motility Granulocyte Chemotaxis Killing Of Cells Of Another Organism Granulocyte Migration Myeloid Leukocyte Migration Cell Killing Inflammatory Response CCR Chemokine Receptor Binding Defense Response To Symbiont Extracellular Region Defense Response To Other Organism Response To External Biotic Stimulus Mononuclear Cell Migration Cytokine-mediated Signaling Pathway Immune Response Positive Regulation Of Locomotion Response To Other Organism Positive Regulation Of Chemotaxis Defense Response Immune System Process Regulation Of Leukocyte Migration Eosinophil Chemotaxis Positive Regulation Of Cell Migration Eosinophil Migration Chemokine Receptor Binding Regulation Of Locomotion Positive Regulation Of Cell Motility G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Chemotaxis CXCR Chemokine Receptor Binding Lymphocyte Migration Regulation Of Cell Motility Positive Regulation Of Calcium Ion Transport T Cell Migration Response To Stress Lymphocyte Chemotaxis	Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Chemotaxis Leukocyte Chemotaxis Locomotion Cell Chemotaxis Humoral Immune Response Cytokine Activity Granulocyte Chemotaxis Defense Response To Symbiont Defense Response To Other Organism Leukocyte Migration Myeloid Leukocyte Migration Granulocyte Migration Killing Of Cells Of Another Organism Response To External Biotic Stimulus Response To Other Organism Immune System Process Defense Response Immune Response Inflammatory Response CXCR Chemokine Receptor Binding Chemokine-mediated Signaling Pathway Cell Killing Cell Migration Cell Motility Mononuclear Cell Migration Chemokine Receptor Binding Neutrophil Chemotaxis CCR Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Extracellular Space Response To Stress Neutrophil Migration Positive Regulation Of T Cell Migration Cytokine-mediated Signaling Pathway CXCR3 Chemokine Receptor Binding Regulation Of Chemotaxis Positive Regulation Of Chemotaxis Positive Regulation Of Lymphocyte Migration Eosinophil Chemotaxis Extracellular Region Positive Regulation Of Leukocyte Chemotaxis Regulation Of T Cell Migration Positive Regulation Of Mononuclear Cell Migration Eosinophil Migration Positive Regulation Of Calcium Ion Transport Regulation Of Locomotion Positive Regulation Of Monocyte Chemotaxis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?