LDLR and LRPAP1

Number of citations of the paper that reports this interaction (PMID 7822276)
19

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		LDLR	LRPAP1
Gene Name		low density lipoprotein receptor	low density lipoprotein receptor-related protein associated protein 1
Image
Gene Ontology Annotations	Cellular Component	Lysosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Coated Pit External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Low-density Lipoprotein Particle Receptor Complex	Extracellular Region Endoplasmic Reticulum Plasma Membrane Cell Surface Integral Component Of Membrane Vesicle Rough Endoplasmic Reticulum Lumen
	Molecular Function	Glycoprotein Binding Low-density Lipoprotein Receptor Activity Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Very-low-density Lipoprotein Particle Receptor Activity Clathrin Heavy Chain Binding	Asialoglycoprotein Receptor Activity Protein Binding Heparin Binding Lipase Binding Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Very-low-density Lipoprotein Particle Receptor Binding
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phototransduction, Visible Light Cholesterol Metabolic Process Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Phosphatidylcholine Catabolic Process Phospholipid Transport Viral Process Intestinal Cholesterol Absorption Cholesterol Transport Low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Small Molecule Metabolic Process Cholesterol Import Regulation Of Cholesterol Homeostasis	Protein Folding Receptor-mediated Endocytosis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Vesicle-mediated Transport Negative Regulation Of Protein Binding Extracellular Negative Regulation Of Signal Transduction Negative Regulation Of Beta-amyloid Clearance
Pathways		Lipoprotein metabolism LDL-mediated lipid transport Visual phototransduction Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Lipid digestion, mobilization, and transport Diseases associated with visual transduction Retinoid metabolism and transport
Drugs		Porfimer Alpha-D-Mannose
Diseases
GWAS		Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness ( 21909108) Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378990) LDL cholesterol ( 23726366 18193043 18193044 20864672 19060906 19060910 19060911 20686565) Lipid metabolism phenotypes ( 22286219 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152) Metabolite levels ( 21909109 22916037) Myocardial infarction (early onset) ( 19198609)
Protein-Protein Interactions		15 interactors: AP1M2 APOB APOE CD36 CREBBP DAB1 DAB2 HSPA5 LDLRAP1 LRPAP1 MAP4 MYLIP PCSK9 PF4 SNX17	18 interactors: ETV7 LDLR LRP1 LRP1B LRP2 LRP8 MAPK1 MAPK3 POLA2 PPM1G RAF1 RALA RALGDS RANBP2 RTN4 SORL1 SORT1 VLDLR
Entrez ID		3949	4043
HPRD ID		06091	00082
Ensembl ID		ENSG00000130164
Uniprot IDs		P01130	P30533
PDB IDs		1AJJ 1D2J 1F5Y 1F8Z 1HJ7 1HZ8 1I0U 1IJQ 1LDL 1LDR 1LRX 1N7D 1XFE 2FCW 2KRI 2LGP 2M7P 2W2M 2W2N 2W2O 2W2P 2W2Q 3BPS 3GCW 3GCX 3M0C 3P5B 3P5C 3SO6	1LRE 1NRE 1OP1 1OV2 2FCW 2FTU 2FYL 2P01 2P03
Enriched GO Terms of Interacting Partners?		Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Receptor-mediated Endocytosis Cholesterol Homeostasis Sterol Homeostasis Vesicle-mediated Transport Plasma Lipoprotein Particle Clearance Lipid Homeostasis Cholesterol Metabolic Process Sterol Metabolic Process Regulation Of Plasma Lipoprotein Particle Levels Cholesterol Transport Sterol Transport Endocytosis Regulation Of Endocytosis Low-density Lipoprotein Particle Clearance Cellular Localization Steroid Metabolic Process Positive Regulation Of Endocytosis Cerebellum Structural Organization Positive Regulation Of Macrophage Derived Foam Cell Differentiation Establishment Of Localization In Cell Regulation Of Signal Transduction Regulation Of Cholesterol Metabolic Process Positive Regulation Of Receptor-mediated Endocytosis Alcohol Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Signaling Regulation Of Vesicle-mediated Transport Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Lipid Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Beta-amyloid Clearance Positive Regulation Of Cell Differentiation Platelet Degranulation Regulation Of Low-density Lipoprotein Particle Clearance CGMP-mediated Signaling Cholesterol Catabolic Process Low-density Lipoprotein Particle Remodeling Transport Regulation Of Cell Differentiation Protein Catabolic Process Positive Regulation Of Cholesterol Storage Lipid Transport Triglyceride Metabolic Process Regulation Of Steroid Metabolic Process Negative Regulation Of Signal Transduction Lipoprotein Transport Lipid Localization Neutral Lipid Metabolic Process	Receptor-mediated Endocytosis Endocytosis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Vesicle-mediated Transport Cellular Response To Growth Factor Stimulus Response To Growth Factor Phototransduction, Visible Light Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Retinoid Metabolic Process Transport Ras Protein Signal Transduction Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Signal Transduction Regulation Of Kinase Activity Steroid Metabolic Process Detection Of Light Stimulus Cholesterol Metabolic Process Signaling Isoprenoid Metabolic Process Regulation Of Catalytic Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Transferase Activity Sterol Metabolic Process Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Golgi Inheritance Regulation Of Cellular Component Organization Alcohol Metabolic Process Caveolin-mediated Endocytosis Regulation Of Phosphorus Metabolic Process Detection Of Abiotic Stimulus Response To Abiotic Stimulus Reelin-mediated Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Golgi Organization Cellular Response To Stimulus Activation Of MAPKK Activity Positive Regulation Of Protein Kinase Activity Locomotion Response To External Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorylation Response To Organic Substance Regulation Of Early Endosome To Late Endosome Transport Viral Process
Tagcloud ?		atresia atretic chicken cloning clusterin correlating follicle follicles granulosa heterodimer hitherto internalize intracellularly intriguing lr8 megalin migrates oocyte oocytes polyacrylamide postovulatory prime sac situations successors thereof uncovered vitellogenesis yolk
Tagcloud (Difference) ?		atresia atretic chicken cloning clusterin correlating follicle follicles granulosa heterodimer hitherto internalize intracellularly intriguing lr8 megalin migrates oocyte oocytes polyacrylamide postovulatory prime sac situations successors thereof uncovered vitellogenesis yolk
Tagcloud (Intersection) ?