PF4 and CCL13

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down)

		PF4	CCL13
Description		platelet factor 4	C-C motif chemokine ligand 13
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Platelet Alpha Granule Lumen	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding Receptor Ligand Activity CXCR3 Chemokine Receptor Binding	Signaling Receptor Binding Cytokine Activity Protein Binding Chemokine Activity CCR Chemokine Receptor Binding
	Biological Process	Monocyte Chemotaxis Chemotaxis Defense Response Inflammatory Response Immune Response Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Platelet Activation Negative Regulation Of Blood Coagulation Neutrophil Chemotaxis Leukocyte Chemotaxis Killing Of Cells Of Another Organism Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Defense Response To Protozoan Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Macrophage Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Signal Transduction Cell-cell Signaling Regulation Of Cell Shape Positive Regulation Of Cell Migration Killing Of Cells Of Another Organism Eosinophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway
Pathways		Platelet degranulation Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall Chemokine receptors bind chemokines G alpha (i) signalling events RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Drotrecogin alfa Heparin
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)	Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233) Metabolite levels ( 23823483)
Interacting Genes		29 interacting genes: CCL11 CCL13 CCL2 CCL20 CCL21 CCL25 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL6 CXCL8 CXCL9 CXCR3 FGF2 LDLR PROC SDC2 SNCA SRGN THBD VCAN XCL1 XCL2	26 interacting genes: ACKR2 ACKR4 APP CCL11 CCL2 CCL21 CCL24 CCL26 CCL28 CCL5 CCL8 CCR3 CCR5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL9 HNRNPH3 MMP1 MMP3 NOD2 PF4 PPBP XCL1
Entrez ID		5196	6357
HPRD ID		01426	03230
Ensembl ID		ENSG00000163737	ENSG00000181374
Uniprot IDs		P02776	Q99616
PDB IDs		1DN3 1F9Q 1F9R 1F9S 1PFM 1PFN 1RHP 4R9W 4R9Y 4RAU	2RA4
Enriched GO Terms of Interacting Partners?		Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Chemotaxis Chemotaxis Antimicrobial Humoral Response Cytokine Activity Locomotion Leukocyte Chemotaxis Chemokine-mediated Signaling Pathway Humoral Immune Response Leukocyte Migration Cell Migration Extracellular Space Cell Motility Granulocyte Chemotaxis Killing Of Cells Of Another Organism Granulocyte Migration Myeloid Leukocyte Migration Cell Killing Inflammatory Response CCR Chemokine Receptor Binding Defense Response To Symbiont Extracellular Region Defense Response To Other Organism Response To External Biotic Stimulus Mononuclear Cell Migration Cytokine-mediated Signaling Pathway Immune Response Positive Regulation Of Locomotion Response To Other Organism Positive Regulation Of Chemotaxis Defense Response Immune System Process Regulation Of Leukocyte Migration Eosinophil Chemotaxis Positive Regulation Of Cell Migration Eosinophil Migration Chemokine Receptor Binding Regulation Of Locomotion Positive Regulation Of Cell Motility G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Chemotaxis CXCR Chemokine Receptor Binding Lymphocyte Migration Regulation Of Cell Motility Positive Regulation Of Calcium Ion Transport T Cell Migration Response To Stress Lymphocyte Chemotaxis	Cell Chemotaxis Chemotaxis Chemokine Activity Locomotion Chemokine-mediated Signaling Pathway Leukocyte Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Leukocyte Migration Myeloid Leukocyte Migration Humoral Immune Response Immune Response Granulocyte Chemotaxis Cytokine Activity Cell Migration Granulocyte Migration Cytokine-mediated Signaling Pathway Cell Motility Immune System Process Defense Response Inflammatory Response Defense Response To Symbiont Mononuclear Cell Migration Defense Response To Other Organism G Protein-coupled Receptor Signaling Pathway Killing Of Cells Of Another Organism CCR Chemokine Receptor Binding Cell Killing Response To External Biotic Stimulus Response To Other Organism Positive Regulation Of Leukocyte Migration Regulation Of Leukocyte Migration Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of Chemotaxis Extracellular Space Response To Stress CXCR Chemokine Receptor Binding Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Extracellular Region Regulation Of Chemotaxis Positive Regulation Of Cell Migration Regulation Of Mononuclear Cell Migration Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Cell Motility Chemokine Receptor Binding Positive Regulation Of Locomotion Cell-cell Signaling Positive Regulation Of Calcium Ion Transport
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