PF4 and VCAN

Number of citations of the paper that reports this interaction (PMID 11083865)
32

Data Source:
BioGRID (pull down)

		PF4	VCAN
Gene Name		platelet factor 4	versican
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Golgi Lumen Membrane Extracellular Matrix Lysosomal Lumen Intracellular Membrane-bounded Organelle
	Molecular Function	Chemokine Activity Heparin Binding CXCR3 Chemokine Receptor Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Hyaluronic Acid Binding Carbohydrate Binding
	Biological Process	Platelet Degranulation Positive Regulation Of Leukocyte Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Blood Coagulation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Platelet Activation Leukocyte Chemotaxis Positive Regulation Of CAMP Metabolic Process Response To Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Proliferation Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Macrophage Differentiation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Cytolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Chemokine-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Skeletal System Development Osteoblast Differentiation Carbohydrate Metabolic Process Cell Adhesion Multicellular Organismal Development Central Nervous System Development Heart Development Cell Recognition Glial Cell Migration Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Small Molecule Metabolic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Platelet degranulation GPCR ligand binding Metabolic disorders of biological oxidation enzymes Formation of Fibrin Clot (Clotting Cascade) Cell surface interactions at the vascular wall Common Pathway GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Response to elevated platelet cytosolic Ca2+ G alpha (i) signalling events Platelet activation, signaling and aggregation	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs		Drotrecogin alfa
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037)	Major depressive disorder ( 20516156)
Protein-Protein Interactions		11 interactors: CCL5 CXCL12 CXCL8 CXCR3 FGF2 LDLR PROC SDC2 SRGN THBD VCAN	24 interactors: ACAN ADAMTS1 CCL2 CCL20 CCL21 CCL5 CCL8 CD44 CXCL10 CXCL12 CXCR3 FBLN1 FBLN2 FBN1 HAPLN1 ITGA4 ITGB1 PF4 PLA2G2A SELL SELP SELPLG TNR XCL1
Entrez ID		5196	1462
HPRD ID		01426	00340
Ensembl ID			ENSG00000038427
Uniprot IDs		P02776	P13611 Q59FG9 Q6MZK8 Q86W61
PDB IDs		1DN3 1F9Q 1F9R 1F9S 1PFM 1PFN 1RHP
Enriched GO Terms of Interacting Partners?		Locomotion Cell Migration Cell Motility Movement Of Cell Or Subcellular Component Positive Regulation Of Chemotaxis Positive Regulation Of Behavior Regulation Of Chemotaxis Chemokine-mediated Signaling Pathway Regulation Of Behavior Leukocyte Migration Chemotaxis Response To External Stimulus Regulation Of Leukocyte Migration Positive Regulation Of Locomotion Cell Chemotaxis Response To Stress Glycosaminoglycan Catabolic Process Negative Regulation Of Wound Healing Positive Regulation Of Leukocyte Chemotaxis Regulation Of Cell Migration Wound Healing Regulation Of Cell Motility Regulation Of Epithelial Cell Proliferation Cellular Calcium Ion Homeostasis Regulation Of Endothelial Cell Proliferation Regulation Of Locomotion Positive Regulation Of Leukocyte Migration Calcium Ion Homeostasis Regulation Of Cellular Component Movement Response To Wounding Positive Regulation Of Calcium Ion Transport Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Cell Migration Angiogenesis Positive Regulation Of Cell Motility Immune System Process Leukocyte Chemotaxis Positive Regulation Of Cellular Component Movement Regulation Of Monocyte Chemotaxis Chemical Homeostasis Regulation Of Wound Healing Cardiovascular System Development Cellular Metal Ion Homeostasis Induction Of Positive Chemotaxis Blood Vessel Morphogenesis Positive Regulation Of T Cell Migration Response To Organic Substance Cellular Cation Homeostasis Response To Radiation Cytokine-mediated Signaling Pathway	Leukocyte Migration Cell Migration Cell Motility Regulation Of Leukocyte Migration Locomotion Positive Regulation Of Leukocyte Migration Cell Chemotaxis Movement Of Cell Or Subcellular Component Regulation Of Lymphocyte Migration Positive Regulation Of Locomotion Positive Regulation Of T Cell Migration Regulation Of T Cell Migration Positive Regulation Of Chemotaxis Chemotaxis Positive Regulation Of Cell Migration Positive Regulation Of Behavior Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cell Motility Cell Adhesion Positive Regulation Of Cellular Component Movement Regulation Of Chemotaxis Regulation Of Cell Migration Inflammatory Response Regulation Of Cell Motility Immune System Process Regulation Of Behavior Leukocyte Chemotaxis Regulation Of Locomotion Regulation Of Cellular Component Movement Chemokine-mediated Signaling Pathway Response To Other Organism Extracellular Matrix Organization Extracellular Structure Organization Response To Biotic Stimulus Regulation Of Immune System Process Cellular Extravasation Lymphocyte Migration Response To External Stimulus Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Calcium Ion Transport Leukocyte Cell-cell Adhesion Leukocyte Tethering Or Rolling Single Organismal Cell-cell Adhesion Response To Organic Substance Defense Response Positive Regulation Of Cell Adhesion Lymphocyte Chemotaxis T Cell Migration Cellular Response To Cytokine Stimulus
Tagcloud ?		10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4v1 phylogenetic physically ppbp primers scyb5 sdf1 separated	abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes wnt
Tagcloud (Difference) ?		10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4v1 phylogenetic physically ppbp primers scyb5 sdf1 separated	abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes wnt
Tagcloud (Intersection) ?