LDLR and LDLRAP1

Number of citations of the paper that reports this interaction (PMID 12221107)
50

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		LDLR	LDLRAP1
Gene Name		low density lipoprotein receptor	low density lipoprotein receptor adaptor protein 1
Image
Gene Ontology Annotations	Cellular Component	Lysosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Coated Pit External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Low-density Lipoprotein Particle Receptor Complex	Early Endosome Cytosol Neurofilament Cytoplasmic Side Of Plasma Membrane Basal Plasma Membrane AP-1 Adaptor Complex AP-2 Adaptor Complex Axon Recycling Endosome
	Molecular Function	Glycoprotein Binding Low-density Lipoprotein Receptor Activity Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Very-low-density Lipoprotein Particle Receptor Activity Clathrin Heavy Chain Binding	Beta-amyloid Binding Phosphotyrosine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Receptor Signaling Complex Scaffold Activity Clathrin Binding Signaling Adaptor Activity AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phototransduction, Visible Light Cholesterol Metabolic Process Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Phosphatidylcholine Catabolic Process Phospholipid Transport Viral Process Intestinal Cholesterol Absorption Cholesterol Transport Low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Small Molecule Metabolic Process Cholesterol Import Regulation Of Cholesterol Homeostasis	Transport Receptor-mediated Endocytosis Cholesterol Metabolic Process Positive Regulation Of Signal Transduction Receptor Internalization Cholesterol Homeostasis Amyloid Precursor Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Establishment Of Protein Localization To Plasma Membrane Receptor-mediated Endocytosis Of Low-density Lipoprotein Particle Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process
Pathways		Lipoprotein metabolism LDL-mediated lipid transport Visual phototransduction Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Lipid digestion, mobilization, and transport Diseases associated with visual transduction Retinoid metabolism and transport
Drugs		Porfimer Alpha-D-Mannose
Diseases
GWAS		Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness ( 21909108) Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378990) LDL cholesterol ( 23726366 18193043 18193044 20864672 19060906 19060910 19060911 20686565) Lipid metabolism phenotypes ( 22286219 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152) Metabolite levels ( 21909109 22916037) Myocardial infarction (early onset) ( 19198609)	Cholesterol, total ( 20686565) LDL cholesterol ( 20686565)
Protein-Protein Interactions		15 interactors: AP1M2 APOB APOE CD36 CREBBP DAB1 DAB2 HSPA5 LDLRAP1 LRPAP1 MAP4 MYLIP PCSK9 PF4 SNX17	7 interactors: AP2B1 APP CLTC LDLR LRP2 OBFC1 TFAP2A
Entrez ID		3949	26119
HPRD ID		06091	05765
Ensembl ID		ENSG00000130164	ENSG00000157978
Uniprot IDs		P01130	B3KR97 Q5SW96
PDB IDs		1AJJ 1D2J 1F5Y 1F8Z 1HJ7 1HZ8 1I0U 1IJQ 1LDL 1LDR 1LRX 1N7D 1XFE 2FCW 2KRI 2LGP 2M7P 2W2M 2W2N 2W2O 2W2P 2W2Q 3BPS 3GCW 3GCX 3M0C 3P5B 3P5C 3SO6	2G30
Enriched GO Terms of Interacting Partners?		Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Receptor-mediated Endocytosis Cholesterol Homeostasis Sterol Homeostasis Vesicle-mediated Transport Plasma Lipoprotein Particle Clearance Lipid Homeostasis Cholesterol Metabolic Process Sterol Metabolic Process Regulation Of Plasma Lipoprotein Particle Levels Cholesterol Transport Sterol Transport Endocytosis Regulation Of Endocytosis Low-density Lipoprotein Particle Clearance Cellular Localization Steroid Metabolic Process Positive Regulation Of Endocytosis Cerebellum Structural Organization Positive Regulation Of Macrophage Derived Foam Cell Differentiation Establishment Of Localization In Cell Regulation Of Signal Transduction Regulation Of Cholesterol Metabolic Process Positive Regulation Of Receptor-mediated Endocytosis Alcohol Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Signaling Regulation Of Vesicle-mediated Transport Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Lipid Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Beta-amyloid Clearance Positive Regulation Of Cell Differentiation Platelet Degranulation Regulation Of Low-density Lipoprotein Particle Clearance CGMP-mediated Signaling Cholesterol Catabolic Process Low-density Lipoprotein Particle Remodeling Transport Regulation Of Cell Differentiation Protein Catabolic Process Positive Regulation Of Cholesterol Storage Lipid Transport Triglyceride Metabolic Process Regulation Of Steroid Metabolic Process Negative Regulation Of Signal Transduction Lipoprotein Transport Lipid Localization Neutral Lipid Metabolic Process	Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Receptor-mediated Endocytosis Vesicle-mediated Transport Steroid Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Response To Light Stimulus Alcohol Metabolic Process Phototransduction, Visible Light Forebrain Development Response To Radiation Retinoid Metabolic Process Diterpenoid Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Detection Of Visible Light Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Optic Cup Structural Organization Phototransduction Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Detection Of Light Stimulus Cholesterol Metabolic Process Isoprenoid Metabolic Process Optic Vesicle Morphogenesis Oculomotor Nerve Formation Synaptic Growth At Neuromuscular Junction Sterol Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cholesterol Import Regulation Of Phosphatidylcholine Catabolic Process Collateral Sprouting In Absence Of Injury Positive Regulation Of Tooth Mineralization Negative Regulation Of Hyaluronan Biosynthetic Process Response To External Stimulus Brain Development Detection Of Abiotic Stimulus Oculomotor Nerve Development Head Development Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Antigen Processing And Presentation Of Peptide Antigen Neuron Development Central Nervous System Development Intestinal Cholesterol Absorption Anterior Neuropore Closure Nervous System Development Optic Cup Morphogenesis Involved In Camera-type Eye Development
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Tagcloud (Difference) ?		atresia atretic chicken cloning clusterin correlating follicle follicles granulosa heterodimer hitherto internalize intracellularly intriguing lr8 megalin migrates oocyte oocytes polyacrylamide postovulatory prime sac situations successors thereof uncovered vitellogenesis yolk
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