LDLR and WEE2-AS1

Number of citations of the paper that reports this interaction (PubMedID 36168628)
47

Data Source:
BioGRID (unspecified method)

		LDLR	WEE2-AS1
Description		low density lipoprotein receptor	WEE2 antisense RNA 1
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Endosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Low-density Lipoprotein Particle Endolysosome Membrane Somatodendritic Compartment Receptor Complex Apical Part Of Cell Sorting Endosome PCSK9-LDLR Complex	U1 SnRNP
	Molecular Function	Amyloid-beta Binding Virus Receptor Activity Protease Binding Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Very-low-density Lipoprotein Particle Receptor Activity Clathrin Heavy Chain Binding Identical Protein Binding Molecular Adaptor Activity Lipoprotein Particle Binding	Pre-mRNA 5'-splice Site Binding
	Biological Process	Retinoid Metabolic Process Negative Regulation Of Receptor Recycling Lipid Metabolic Process Lipid Transport Endocytosis Receptor-mediated Endocytosis Phagocytosis Long-term Memory Steroid Metabolic Process Cholesterol Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Phosphatidylcholine Catabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Phospholipid Transport Intestinal Cholesterol Absorption Cholesterol Transport Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance High-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Symbiont Entry Into Host Cell Artery Morphogenesis Positive Regulation Of Inflammatory Response Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Artery Development Response To Caloric Restriction Negative Regulation Of Astrocyte Activation Cholesterol Import Cellular Response To Fatty Acid Cellular Response To Low-density Lipoprotein Particle Stimulus Receptor-mediated Endocytosis Involved In Cholesterol Transport Regulation Of Cholesterol Metabolic Process Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Negative Regulation Of Microglial Cell Activation Positive Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Amyloid Fibril Formation	MRNA 5'-splice Site Recognition
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance Chylomicron clearance LDL clearance Retinoid metabolism and transport
Drugs		Porfimer sodium
Diseases		Hypercholesterolemia, autosomal dominant; Hyperlipoproteinemia, type IIa
GWAS		Abdominal aortic aneurysm ( 27899403 24046328) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Apolipoprotein B levels ( 32203549) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness ( 21909108) Carotid plaque ( 30510157) Cholesterol ( 31902109) Cholesterol, total ( 20686565 24097068 26582766 19060911 25961943) Coronary artery disease ( 32469254 26343387 24262325 33020668 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Cortisol levels (saliva) ( 28843169) Disorders of lipid metabolism ( 30166351) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol ( 26582766 30275531 18193044 24097068 23726366 25961943 21347282 20864672 20686565 19060906 18193043 19060910 19060911) LDL cholesterol levels ( 32203549 26690388 30698716 28334899) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222 22286219) Lipoprotein (a) levels ( 33730874) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152) Low density lipoprotein cholesterol levels ( 30911093 33339817 31217584 29403010) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antithrombotic agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Medication use (salicylic acid and derivatives) ( 31015401) Metabolite levels ( 21909109 22916037 23823483) Myocardial infarction ( 33532862 26343387) Myocardial infarction (early onset) ( 19198609) Parental lifespan ( 30642433) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Peripheral artery disease ( 31285632) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 28334899 31217584 30911093 33339817 29403010)
Interacting Genes		18 interacting genes: AP1M2 APOB APOE CD36 CREBBP DAB1 DAB2 HSPA5 LDLRAP1 LRPAP1 MAP4 MTIF3 MYLIP PCSK9 PF4 SNX17 TLE5 WEE2-AS1	161 interacting genes: AASS ACSL3 ACTG1 AGAP1 AHNAK AJUBA AKAP11 ALB ALKBH4 ANXA2 ARL6IP4 ASPSCR1 ATAD3A BCLAF1 BRAT1 CALML5 CLPB COPB2 COPG1 CSTF1 CTNND1 CTU2 DAXX DDX1 DDX23 DIDO1 DLST DNAAF5 DOHH DPYSL4 DSC1 DSP EEF1A1 EGR2 EIF3A ELL EMD EPM2AIP1 ERAP1 ERH EXOC4 FAM120B FAM83H FLG FLG2 FMR1 FOXK1 FXR1 FXR2 GAB1 GAPDH GBF1 GNL3 GRB10 GSDME GSN GTF3C1 GTPBP1 GTSE1 HARS1 HAX1 HMGA1 HMGCS1 HNRNPA2B1 HNRNPC HNRNPH1 HNRNPH2 HNRNPLL HNRNPM HSP90AA1 HSP90AB1 HSPA6 HSPA8 HSPB1 IFIT1 IGF2BP1 IGF2BP3 KCTD3 KIF20A KIF22 LAMC1 LARP7 LDLR LUC7L2 MAGED2 MAP1A MED23 MINDY3 MOB1A MSH6 MYH9 MYO1C NCKAP1 NDFIP1 NEK9 NISCH NPM1 NUP160 NXF1 PABPC1 PALS2 PARP1 PCMT1 PDCD2L PDXP PIGU PJA2 PLEC POP1 PPL PPM1F PRKAR2A PSMB1 PSMD1 PTK2 QTRT2 RAB5A RAF1 RETREG2 RPL13 RPLP2 RPN2 RPP30 RPRD1B RPS17 RPS2 RPS28 RPS29 RPS8 S100A14 S100A7 SEC13 SERBP1 SHKBP1 SHTN1 SKIC2 SLC25A11 SLC27A3 SNX8 SQSTM1 SRP68 STAT5B TANK THBS1 THRAP3 TIMELESS TMPO TOR1AIP2 TPR TRIM21 TRIM56 TRMT10C TTC28 TUBA1B TUBB3 TUBB4B U2AF1 UBB USP1 XRCC6 YBX1
Entrez ID		3949	285962
HPRD ID		06091	08286
Ensembl ID		ENSG00000130164	ENSG00000228775
Uniprot IDs		H0YMQ3 P01130
PDB IDs		1AJJ 1D2J 1F5Y 1F8Z 1HJ7 1HZ8 1I0U 1IJQ 1LDL 1LDR 1N7D 1XFE 2FCW 2KRI 2LGP 2M7P 2MG9 2W2M 2W2N 2W2O 2W2P 2W2Q 3BPS 3GCW 3GCX 3M0C 3P5B 3P5C 3SO6 4NE9 5OY9 5OYL 9BD8 9BDE 9BDT 9COO
Enriched GO Terms of Interacting Partners?		Low-density Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding Plasma Lipoprotein Particle Clearance Regulation Of Endocytosis Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Sterol Homeostasis Cholesterol Homeostasis Cholesterol Metabolic Process Sterol Metabolic Process Negative Regulation Of Cellular Component Organization Low-density Lipoprotein Particle Clearance Positive Regulation Of Endocytosis Cholesterol Transport Lipid Homeostasis Negative Regulation Of Lipoprotein Particle Clearance Receptor-mediated Endocytosis Regulation Of Vesicle-mediated Transport Clathrin Adaptor Activity Negative Regulation Of Cell Projection Organization Regulation Of Low-density Lipoprotein Particle Clearance Chylomicron Remnant Cerebellum Structural Organization Positive Regulation Of Macrophage Derived Foam Cell Differentiation Sterol Transport Amyloid-beta Binding Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Steroid Metabolic Process Regulation Of Steroid Metabolic Process Lipoprotein Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cellular Component Organization Negative Regulation Of Neuron Projection Development Regulation Of Receptor-mediated Endocytosis Cellular Response To Lipoprotein Particle Stimulus Alcohol Metabolic Process Receptor Ligand Activity Intermediate-density Lipoprotein Particle Positive Regulation Of Steroid Metabolic Process Regulation Of Lipid Transport Intracellular Membrane-bounded Organelle Lipoprotein Biosynthetic Process Early Endosome Regulation Of Cholesterol Metabolic Process Heparin Binding Cellular Response To Amyloid-beta Organic Hydroxy Compound Transport Positive Regulation Of Cholesterol Storage Positive Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Binding Positive Regulation Of Amyloid-beta Clearance	RNA Binding Cytosol Ribonucleoprotein Complex Cytoplasm Nucleus Focal Adhesion Extracellular Exosome Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleic Acid Metabolic Process RNA Metabolic Process Regulation Of Protein Metabolic Process Cytoplasmic Stress Granule MRNA Binding N6-methyladenosine-containing RNA Reader Activity Protein Binding MRNA Processing RNA Transport Nucleolus MRNA Transport Biological_process RNA Processing Nucleic Acid Binding Cellular Response To Heat Translation Regulator Activity Positive Regulation Of Protein Metabolic Process Nucleoplasm Positive Regulation Of Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cornified Envelope Positive Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process Positive Regulation Of Biosynthetic Process Response To Heat Regulation Of Translation Regulation Of MRNA Stability CRD-mediated MRNA Stabilization Ficolin-1-rich Granule Lumen MRNA 3'-UTR Binding Nucleobase-containing Compound Transport Regulation Of RNA Stability Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding Structural Molecule Activity Positive Regulation Of Gene Expression RNA Splicing Cadherin Binding Negative Regulation Of MRNA Catabolic Process Regulation Of Plasma Membrane Organization
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