LDLR and DAB2

Number of citations of the paper that reports this interaction (PubMedID 11247302)
0

Data Source:
BioGRID (pull down)

		LDLR	DAB2
Description		low density lipoprotein receptor	DAB adaptor protein 2
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GO Annotations	Cellular Component	Lysosome Endosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Low-density Lipoprotein Particle Endolysosome Membrane Somatodendritic Compartment Receptor Complex Apical Part Of Cell Sorting Endosome PCSK9-LDLR Complex	Fibrillar Center Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Amyloid-beta Binding Virus Receptor Activity Protease Binding Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Very-low-density Lipoprotein Particle Receptor Activity Clathrin Heavy Chain Binding Identical Protein Binding Molecular Adaptor Activity Lipoprotein Particle Binding	Protein Binding Clathrin Adaptor Activity Cargo Receptor Activity SMAD Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Retinoid Metabolic Process Negative Regulation Of Receptor Recycling Lipid Metabolic Process Lipid Transport Endocytosis Receptor-mediated Endocytosis Phagocytosis Long-term Memory Steroid Metabolic Process Cholesterol Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Phosphatidylcholine Catabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Phospholipid Transport Intestinal Cholesterol Absorption Cholesterol Transport Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance High-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Symbiont Entry Into Host Cell Artery Morphogenesis Positive Regulation Of Inflammatory Response Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Artery Development Response To Caloric Restriction Negative Regulation Of Astrocyte Activation Cholesterol Import Cellular Response To Fatty Acid Cellular Response To Low-density Lipoprotein Particle Stimulus Receptor-mediated Endocytosis Involved In Cholesterol Transport Regulation Of Cholesterol Metabolic Process Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Negative Regulation Of Microglial Cell Activation Positive Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Amyloid Fibril Formation	Negative Regulation Of Transcription By RNA Polymerase II Endocytosis Receptor-mediated Endocytosis Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Neuron Projection Development Protein Transport Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Leading Edge Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Clathrin Coat Assembly Response To Steroid Hormone Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Response To Salt Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Aldosterone Secretion
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance Chylomicron clearance LDL clearance Retinoid metabolism and transport	Gap junction degradation Formation of annular gap junctions Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Porfimer sodium
Diseases		Hypercholesterolemia, autosomal dominant; Hyperlipoproteinemia, type IIa
GWAS		Abdominal aortic aneurysm ( 27899403 24046328) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Apolipoprotein B levels ( 32203549) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness ( 21909108) Carotid plaque ( 30510157) Cholesterol ( 31902109) Cholesterol, total ( 20686565 24097068 26582766 19060911 25961943) Coronary artery disease ( 32469254 26343387 24262325 33020668 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Cortisol levels (saliva) ( 28843169) Disorders of lipid metabolism ( 30166351) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol ( 26582766 30275531 18193044 24097068 23726366 25961943 21347282 20864672 20686565 19060906 18193043 19060910 19060911) LDL cholesterol levels ( 32203549 26690388 30698716 28334899) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222 22286219) Lipoprotein (a) levels ( 33730874) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152) Low density lipoprotein cholesterol levels ( 30911093 33339817 31217584 29403010) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antithrombotic agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Medication use (salicylic acid and derivatives) ( 31015401) Metabolite levels ( 21909109 22916037 23823483) Myocardial infarction ( 33532862 26343387) Myocardial infarction (early onset) ( 19198609) Parental lifespan ( 30642433) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Peripheral artery disease ( 31285632) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 28334899 31217584 30911093 33339817 29403010)	Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301 29403010) Birth weight ( 31043758) Chronic kidney disease ( 20383146 31152163) Creatinine levels ( 31015462) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31451708 31152163 30604766 31015462) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) HDL cholesterol levels ( 32203549) Health literacy ( 31250787) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Non-albumin protein levels ( 29403010) Pancreatic cancer ( 22158540) Premature menopause in childhood cancer survivors ( 29432556) Self-reported allergy ( 23817569) Systemic lupus erythematosus ( 19838195) Urate levels ( 23263486) Waist-hip ratio ( 28552196)
Interacting Genes		18 interacting genes: AP1M2 APOB APOE CD36 CREBBP DAB1 DAB2 HSPA5 LDLRAP1 LRPAP1 MAP4 MTIF3 MYLIP PCSK9 PF4 SNX17 TLE5 WEE2-AS1	40 interacting genes: AP2M1 APLP1 APLP2 APP ATXN1L AXIN1 CDC16 CDK1 CSK DAB2IP DIP2A DVL1 DVL3 FCHO1 FCHO2 FGR GRB2 INPP5D ITGB3 ITGB5 ITSN1 LDLR LRP1 LRP2 LRP8 MIB1 MYO6 NECAP1 PIN1 PRKCB PRKCD PRKCG SGIP1 SMAD2 SMAD3 SMURF2 SRC SUMO2 TGFBR1 TGFBR2
Entrez ID		3949	1601
HPRD ID		06091	03139
Ensembl ID		ENSG00000130164	ENSG00000153071
Uniprot IDs		H0YMQ3 P01130	B2RAW0 P98082
PDB IDs		1AJJ 1D2J 1F5Y 1F8Z 1HJ7 1HZ8 1I0U 1IJQ 1LDL 1LDR 1N7D 1XFE 2FCW 2KRI 2LGP 2M7P 2MG9 2W2M 2W2N 2W2O 2W2P 2W2Q 3BPS 3GCW 3GCX 3M0C 3P5B 3P5C 3SO6 4NE9 5OY9 5OYL 9BD8 9BDE 9BDT 9COO	2LSW 6O5O 6OVF
Enriched GO Terms of Interacting Partners?		Low-density Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding Plasma Lipoprotein Particle Clearance Regulation Of Endocytosis Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Sterol Homeostasis Cholesterol Homeostasis Cholesterol Metabolic Process Sterol Metabolic Process Negative Regulation Of Cellular Component Organization Low-density Lipoprotein Particle Clearance Positive Regulation Of Endocytosis Cholesterol Transport Lipid Homeostasis Negative Regulation Of Lipoprotein Particle Clearance Receptor-mediated Endocytosis Regulation Of Vesicle-mediated Transport Clathrin Adaptor Activity Negative Regulation Of Cell Projection Organization Regulation Of Low-density Lipoprotein Particle Clearance Chylomicron Remnant Cerebellum Structural Organization Positive Regulation Of Macrophage Derived Foam Cell Differentiation Sterol Transport Amyloid-beta Binding Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Steroid Metabolic Process Regulation Of Steroid Metabolic Process Lipoprotein Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cellular Component Organization Negative Regulation Of Neuron Projection Development Regulation Of Receptor-mediated Endocytosis Cellular Response To Lipoprotein Particle Stimulus Alcohol Metabolic Process Receptor Ligand Activity Intermediate-density Lipoprotein Particle Positive Regulation Of Steroid Metabolic Process Regulation Of Lipid Transport Intracellular Membrane-bounded Organelle Lipoprotein Biosynthetic Process Early Endosome Regulation Of Cholesterol Metabolic Process Heparin Binding Cellular Response To Amyloid-beta Organic Hydroxy Compound Transport Positive Regulation Of Cholesterol Storage Positive Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Binding Positive Regulation Of Amyloid-beta Clearance	Clathrin-coated Pit Endocytosis Import Into Cell Plasma Membrane Cell Surface Receptor Signaling Pathway Anatomical Structure Morphogenesis Receptor Complex Signal Transduction Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Receptor-mediated Endocytosis Vesicle-mediated Transport Regulation Of Cellular Component Organization Intracellular Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Signaling Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Developmental Process Response To Growth Factor Regulation Of Cell Communication Clathrin-dependent Endocytosis Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Tube Morphogenesis Positive Regulation Of Protein Catabolic Process Regulation Of Transport Low-density Lipoprotein Particle Receptor Activity Membrane I-SMAD Binding Cellular Response To Oxygen-containing Compound Presynaptic Endocytosis Regulation Of Cellular Response To Growth Factor Stimulus Vesicle-mediated Transport In Synapse Regulation Of Protein Localization Immune Response-activating Cell Surface Receptor Signaling Pathway SMAD Binding Cytosol Positive Regulation Of Lysosomal Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Neuron Projection Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Cell Projection Morphogenesis
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