LDLR and AP1M2

Number of citations of the paper that reports this interaction (PMID 11157985)
82

Data Source:
HPRD (in vitro, in vivo)

		LDLR	AP1M2
Gene Name		low density lipoprotein receptor	adaptor-related protein complex 1, mu 2 subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Coated Pit External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Low-density Lipoprotein Particle Receptor Complex	Golgi Membrane Lysosomal Membrane Cytosol Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Glycoprotein Binding Low-density Lipoprotein Receptor Activity Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Very-low-density Lipoprotein Particle Receptor Activity Clathrin Heavy Chain Binding
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phototransduction, Visible Light Cholesterol Metabolic Process Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Phosphatidylcholine Catabolic Process Phospholipid Transport Viral Process Intestinal Cholesterol Absorption Cholesterol Transport Low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Small Molecule Metabolic Process Cholesterol Import Regulation Of Cholesterol Homeostasis	Protein Targeting Post-Golgi Vesicle-mediated Transport Vesicle Targeting Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Defense Response To Virus By Virus Membrane Organization
Pathways		Lipoprotein metabolism LDL-mediated lipid transport Visual phototransduction Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Lipid digestion, mobilization, and transport Diseases associated with visual transduction Retinoid metabolism and transport	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs		Porfimer Alpha-D-Mannose
Diseases
GWAS		Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness ( 21909108) Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378990) LDL cholesterol ( 23726366 18193043 18193044 20864672 19060906 19060910 19060911 20686565) Lipid metabolism phenotypes ( 22286219 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152) Metabolite levels ( 21909109 22916037) Myocardial infarction (early onset) ( 19198609)
Protein-Protein Interactions		15 interactors: AP1M2 APOB APOE CD36 CREBBP DAB1 DAB2 HSPA5 LDLRAP1 LRPAP1 MAP4 MYLIP PCSK9 PF4 SNX17	20 interactors: A2M AP1B1 AP1G1 AP1M1 AP1S1 AP2B1 APP BLMH ECSIT EHD2 GAK LDLR LOXL4 MAST1 NDRG1 PSEN1 PVR RAB3A RAB3D TGOLN2
Entrez ID		3949	10053
HPRD ID		06091	06296
Ensembl ID		ENSG00000130164	ENSG00000129354
Uniprot IDs		P01130	Q9Y6Q5
PDB IDs		1AJJ 1D2J 1F5Y 1F8Z 1HJ7 1HZ8 1I0U 1IJQ 1LDL 1LDR 1LRX 1N7D 1XFE 2FCW 2KRI 2LGP 2M7P 2W2M 2W2N 2W2O 2W2P 2W2Q 3BPS 3GCW 3GCX 3M0C 3P5B 3P5C 3SO6
Enriched GO Terms of Interacting Partners?		Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Receptor-mediated Endocytosis Cholesterol Homeostasis Sterol Homeostasis Vesicle-mediated Transport Plasma Lipoprotein Particle Clearance Lipid Homeostasis Cholesterol Metabolic Process Sterol Metabolic Process Regulation Of Plasma Lipoprotein Particle Levels Cholesterol Transport Sterol Transport Endocytosis Regulation Of Endocytosis Low-density Lipoprotein Particle Clearance Cellular Localization Steroid Metabolic Process Positive Regulation Of Endocytosis Cerebellum Structural Organization Positive Regulation Of Macrophage Derived Foam Cell Differentiation Establishment Of Localization In Cell Regulation Of Signal Transduction Regulation Of Cholesterol Metabolic Process Positive Regulation Of Receptor-mediated Endocytosis Alcohol Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Signaling Regulation Of Vesicle-mediated Transport Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Lipid Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Beta-amyloid Clearance Positive Regulation Of Cell Differentiation Platelet Degranulation Regulation Of Low-density Lipoprotein Particle Clearance CGMP-mediated Signaling Cholesterol Catabolic Process Low-density Lipoprotein Particle Remodeling Transport Regulation Of Cell Differentiation Protein Catabolic Process Positive Regulation Of Cholesterol Storage Lipid Transport Triglyceride Metabolic Process Regulation Of Steroid Metabolic Process Negative Regulation Of Signal Transduction Lipoprotein Transport Lipid Localization Neutral Lipid Metabolic Process	Vesicle-mediated Transport Regulation Of Defense Response To Virus By Virus Establishment Of Localization In Cell Regulation Of Defense Response To Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Endocytosis Antigen Processing And Presentation Of Peptide Antigen Cellular Localization Intracellular Transport Antigen Processing And Presentation Viral Process Intracellular Protein Transport Cellular Protein Localization Protein Transport Protein Localization Positive Regulation Of Regulated Secretory Pathway Establishment Of Protein Localization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Post-Golgi Vesicle-mediated Transport Transport Immune System Process Regulation Of Immune System Process Response To External Stimulus Regulation Of Regulated Secretory Pathway Exocytosis Receptor-mediated Endocytosis Synaptic Vesicle Exocytosis Response To Stimulus Positive Regulation Of Exocytosis Endosome To Melanosome Transport Pigment Granule Maturation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Pigment Accumulation Regulation Of ERBB Signaling Pathway Membrane Organization Secretion By Cell Golgi Vesicle Transport Neurotransmitter Secretion Synaptic Vesicle Transport Cell Differentiation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Establishment Of Organelle Localization Secretion Positive Regulation Of Natural Killer Cell Mediated Immunity Melanosome Organization Pigment Granule Organization Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Neurotransmitter Levels
Tagcloud ?		atresia atretic chicken cloning clusterin correlating follicle follicles granulosa heterodimer hitherto internalize intracellularly intriguing lr8 megalin migrates oocyte oocytes polyacrylamide postovulatory prime sac situations successors thereof uncovered vitellogenesis yolk	acaa1 analogous aspirates cgn combat dcn ddr1 deadly ec ecs efemp2 endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppfibp2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine
Tagcloud (Difference) ?		atresia atretic chicken cloning clusterin correlating follicle follicles granulosa heterodimer hitherto internalize intracellularly intriguing lr8 megalin migrates oocyte oocytes polyacrylamide postovulatory prime sac situations successors thereof uncovered vitellogenesis yolk	acaa1 analogous aspirates cgn combat dcn ddr1 deadly ec ecs efemp2 endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppfibp2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine
Tagcloud (Intersection) ?