PF4 and CXCL17

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down)

		PF4	CXCL17
Description		platelet factor 4	C-X-C motif chemokine ligand 17
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Platelet Alpha Granule Lumen	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding Receptor Ligand Activity CXCR3 Chemokine Receptor Binding	Protein Binding
	Biological Process	Monocyte Chemotaxis Chemotaxis Defense Response Inflammatory Response Immune Response Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Platelet Activation Negative Regulation Of Blood Coagulation Neutrophil Chemotaxis Leukocyte Chemotaxis Killing Of Cells Of Another Organism Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Defense Response To Protozoan Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Macrophage Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Angiogenesis Chemotaxis Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Cell Differentiation Macrophage Chemotaxis Negative Regulation Of Inflammatory Response Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis
Pathways		Platelet degranulation Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall Chemokine receptors bind chemokines G alpha (i) signalling events RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs		Drotrecogin alfa Heparin
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		29 interacting genes: CCL11 CCL13 CCL2 CCL20 CCL21 CCL25 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL6 CXCL8 CXCL9 CXCR3 FGF2 LDLR PROC SDC2 SNCA SRGN THBD VCAN XCL1 XCL2	16 interacting genes: CCL13 CCL2 CCL20 CCL21 CCL25 CCL26 CCL28 CCL5 CCL8 CXCL10 CXCL12 CXCL14 CXCL9 PF4 XCL1 XCL2
Entrez ID		5196	284340
HPRD ID		01426	18264
Ensembl ID		ENSG00000163737	ENSG00000189377
Uniprot IDs		P02776	Q6UXB2
PDB IDs		1DN3 1F9Q 1F9R 1F9S 1PFM 1PFN 1RHP 4R9W 4R9Y 4RAU
Enriched GO Terms of Interacting Partners?		Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Chemotaxis Chemotaxis Antimicrobial Humoral Response Cytokine Activity Locomotion Leukocyte Chemotaxis Chemokine-mediated Signaling Pathway Humoral Immune Response Leukocyte Migration Cell Migration Extracellular Space Cell Motility Granulocyte Chemotaxis Killing Of Cells Of Another Organism Granulocyte Migration Myeloid Leukocyte Migration Cell Killing Inflammatory Response CCR Chemokine Receptor Binding Defense Response To Symbiont Extracellular Region Defense Response To Other Organism Response To External Biotic Stimulus Mononuclear Cell Migration Cytokine-mediated Signaling Pathway Immune Response Positive Regulation Of Locomotion Response To Other Organism Positive Regulation Of Chemotaxis Defense Response Immune System Process Regulation Of Leukocyte Migration Eosinophil Chemotaxis Positive Regulation Of Cell Migration Eosinophil Migration Chemokine Receptor Binding Regulation Of Locomotion Positive Regulation Of Cell Motility G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Chemotaxis CXCR Chemokine Receptor Binding Lymphocyte Migration Regulation Of Cell Motility Positive Regulation Of Calcium Ion Transport T Cell Migration Response To Stress Lymphocyte Chemotaxis	Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell Chemotaxis Cytokine Activity Humoral Immune Response Chemotaxis Locomotion Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Leukocyte Chemotaxis Granulocyte Migration Leukocyte Migration Killing Of Cells Of Another Organism Myeloid Leukocyte Migration Defense Response To Symbiont CCR Chemokine Receptor Binding Defense Response To Other Organism Cell Migration Cell Killing Cell Motility Response To Other Organism Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Response To External Biotic Stimulus Defense Response Extracellular Space Eosinophil Chemotaxis Eosinophil Migration Chemokine Receptor Binding Mononuclear Cell Migration Immune System Process Regulation Of Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Migration Extracellular Region Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Lymphocyte Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of T Cell Migration CXCR Chemokine Receptor Binding Negative Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Lymphocyte Migration Response To Stress Positive Regulation Of Mononuclear Cell Migration
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