PF4 and SDC2

Number of citations of the paper that reports this interaction (PMID 7524669)
6

Data Source:
HPRD (in vitro)

		PF4	SDC2
Gene Name		platelet factor 4	syndecan 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen	Golgi Lumen Plasma Membrane Integral Component Of Membrane Neuronal Cell Body Lysosomal Lumen Synapse
	Molecular Function	Chemokine Activity Heparin Binding CXCR3 Chemokine Receptor Binding	Protein Binding PDZ Domain Binding
	Biological Process	Platelet Degranulation Positive Regulation Of Leukocyte Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Blood Coagulation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Platelet Activation Leukocyte Chemotaxis Positive Regulation Of CAMP Metabolic Process Response To Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Proliferation Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Macrophage Differentiation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Cytolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Chemokine-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Retinoid Metabolic Process Response To Hypoxia Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Axon Guidance Phototransduction, Visible Light Biological_process Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Response To Caffeine Wound Healing Small Molecule Metabolic Process Ephrin Receptor Signaling Pathway Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Platelet degranulation GPCR ligand binding Metabolic disorders of biological oxidation enzymes Formation of Fibrin Clot (Clotting Cascade) Cell surface interactions at the vascular wall Common Pathway GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Response to elevated platelet cytosolic Ca2+ G alpha (i) signalling events Platelet activation, signaling and aggregation	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Axon guidance Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism EPHB-mediated forward signaling Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D EPH-Ephrin signaling A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Diseases associated with visual transduction Defective EXT1 causes exostoses 1, TRPS2 and CHDS Syndecan interactions MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs		Drotrecogin alfa
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037)
Protein-Protein Interactions		11 interactors: CCL5 CXCL12 CXCL8 CXCR3 FGF2 LDLR PROC SDC2 SRGN THBD VCAN	26 interactors: BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF KAL1 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4
Entrez ID		5196	6383
HPRD ID		01426	00803
Ensembl ID			ENSG00000169439
Uniprot IDs		P02776	E9PBI9 P34741
PDB IDs		1DN3 1F9Q 1F9R 1F9S 1PFM 1PFN 1RHP
Enriched GO Terms of Interacting Partners?		Locomotion Cell Migration Cell Motility Movement Of Cell Or Subcellular Component Positive Regulation Of Chemotaxis Positive Regulation Of Behavior Regulation Of Chemotaxis Chemokine-mediated Signaling Pathway Regulation Of Behavior Leukocyte Migration Chemotaxis Response To External Stimulus Regulation Of Leukocyte Migration Positive Regulation Of Locomotion Cell Chemotaxis Response To Stress Glycosaminoglycan Catabolic Process Negative Regulation Of Wound Healing Positive Regulation Of Leukocyte Chemotaxis Regulation Of Cell Migration Wound Healing Regulation Of Cell Motility Regulation Of Epithelial Cell Proliferation Cellular Calcium Ion Homeostasis Regulation Of Endothelial Cell Proliferation Regulation Of Locomotion Positive Regulation Of Leukocyte Migration Calcium Ion Homeostasis Regulation Of Cellular Component Movement Response To Wounding Positive Regulation Of Calcium Ion Transport Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Cell Migration Angiogenesis Positive Regulation Of Cell Motility Immune System Process Leukocyte Chemotaxis Positive Regulation Of Cellular Component Movement Regulation Of Monocyte Chemotaxis Chemical Homeostasis Regulation Of Wound Healing Cardiovascular System Development Cellular Metal Ion Homeostasis Induction Of Positive Chemotaxis Blood Vessel Morphogenesis Positive Regulation Of T Cell Migration Response To Organic Substance Cellular Cation Homeostasis Response To Radiation Cytokine-mediated Signaling Pathway	Regulation Of Body Fluid Levels Platelet Activation Wound Healing Response To Wounding Blood Coagulation Hemostasis Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Regulation Of Epithelial Cell Proliferation Cell Activation Regulation Of Angiogenesis Regulation Of Cell Migration Multicellular Organismal Development Regulation Of Epithelial Cell Migration Response To External Stimulus Regulation Of Cell Motility Regulation Of Cell Proliferation Response To Stimulus Regulation Of Locomotion Regulation Of Cellular Component Movement Locomotion Positive Regulation Of Signal Transduction System Development Developmental Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endothelial Cell Migration Anatomical Structure Development Chemotaxis Movement Of Cell Or Subcellular Component Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Regulation Of Wound Healing Regulation Of Cell Differentiation Regulation Of Cellular Protein Metabolic Process Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stress Positive Regulation Of Endothelial Cell Migration Regulation Of Cellular Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Migration Cell Development Histone H3-T6 Phosphorylation
Tagcloud ?		10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4v1 phylogenetic physically ppbp primers scyb5 sdf1 separated	affymetrix akt2 aroused bioinformatics ccng2 ccnu cdkn2c chemosensitivity ep300 excavate gbm id2 igfbp3 map2k2 mdm4 pdgfd perfected picked plethora prkca raf1 rbl1 rigorous semustine socs2 stmn1 tcf7l1 tubb unsatisfactory
Tagcloud (Difference) ?		10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4v1 phylogenetic physically ppbp primers scyb5 sdf1 separated	affymetrix akt2 aroused bioinformatics ccng2 ccnu cdkn2c chemosensitivity ep300 excavate gbm id2 igfbp3 map2k2 mdm4 pdgfd perfected picked plethora prkca raf1 rbl1 rigorous semustine socs2 stmn1 tcf7l1 tubb unsatisfactory
Tagcloud (Intersection) ?