LAMC2 and COL7A1

Number of citations of the paper that reports this interaction (PMID 9989793)
13

Data Source:
HPRD (in vivo, in vitro)

		LAMC2	COL7A1
Gene Name		laminin, gamma 2	collagen, type VII, alpha 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Laminin-2 Complex Laminin-5 Complex Extracellular Space Cell Cortex Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Collagen Type VII Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Heparin Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding Identical Protein Binding
	Biological Process	Cell Adhesion Epidermis Development Extracellular Matrix Disassembly Extracellular Matrix Organization Hemidesmosome Assembly Cell Junction Assembly	Cell Adhesion Epidermis Development Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation
Pathways		Cell junction organization Type I hemidesmosome assembly Collagen formation Laminin interactions Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	Collagen formation Laminin interactions Collagen degradation Anchoring fibril formation Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS		Coronary heart disease ( 21347282) Systemic lupus erythematosus ( 21408207)
Protein-Protein Interactions		6 interactors: BMP1 COL7A1 FBLN2 LAMB3 NID1 SLA2	14 interactors: BMP1 COL1A1 COL4A1 FBXL2 FN1 HSPA8 LAMA1 LAMA5 LAMB3 LAMC2 MMP2 SHKBP1 THBS1 ZC3H7A
Entrez ID		3918	1294
HPRD ID		01031	00358
Ensembl ID		ENSG00000058085	ENSG00000114270
Uniprot IDs		Q13753	Q02388 Q59F16
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Endodermal Cell Differentiation Endoderm Formation Cell Adhesion Endoderm Development Positive Regulation Of Cell-substrate Adhesion Formation Of Primary Germ Layer Gastrulation Regulation Of Cell-substrate Adhesion Epidermis Development Negative Regulation Of Calcium-mediated Signaling Hemidesmosome Assembly Positive Regulation Of Cell Adhesion Glomerular Basement Membrane Development Basement Membrane Organization Cartilage Condensation Tissue Development	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Tissue Development Blood Vessel Development Vasculature Development Cell-substrate Junction Assembly Anatomical Structure Morphogenesis Blood Vessel Morphogenesis Locomotion Cardiovascular System Development Movement Of Cell Or Subcellular Component Anatomical Structure Formation Involved In Morphogenesis Angiogenesis Endodermal Cell Differentiation Cell Morphogenesis Involved In Differentiation Anatomical Structure Development Retinal Blood Vessel Morphogenesis Cell Junction Assembly Endoderm Formation Cellular Response To Amino Acid Stimulus Developmental Process Collagen Catabolic Process Organ Morphogenesis Intramembranous Ossification Collagen Metabolic Process Cell Morphogenesis Cell Differentiation Multicellular Organismal Macromolecule Metabolic Process Skeletal System Morphogenesis Bone Trabecula Formation Endoderm Development Multicellular Organismal Metabolic Process Multicellular Organismal Development Cell Adhesion Retina Vasculature Morphogenesis In Camera-type Eye Hemidesmosome Assembly Response To Amino Acid Bone Trabecula Morphogenesis Axon Guidance Formation Of Primary Germ Layer System Development Cell Projection Morphogenesis Cell Part Morphogenesis Retina Vasculature Development In Camera-type Eye Morphogenesis Of A Polarized Epithelium Cellular Response To Acid Chemical Branching Involved In Salivary Gland Morphogenesis Gastrulation Platelet Activation
Tagcloud ?		accumulating adhesion alpha3beta1 alpha6beta4 anticancer attractive autocrine barrier basement biomarker countries crucial drive egfrs indicates influences inhibiting integrins lamina laminin laminins layers mechanical membranes migration morbidity network transformed tumorigenesis
Tagcloud (Difference) ?		accumulating adhesion alpha3beta1 alpha6beta4 anticancer attractive autocrine barrier basement biomarker countries crucial drive egfrs indicates influences inhibiting integrins lamina laminin laminins layers mechanical membranes migration morbidity network transformed tumorigenesis
Tagcloud (Intersection) ?