LAMC2 and NID1

Number of citations of the paper that reports this interaction (PMID 11733994)
25

Data Source:
HPRD (in vitro)

		LAMC2	NID1
Gene Name		laminin, gamma 2	nidogen 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Laminin-2 Complex Laminin-5 Complex Extracellular Space Cell Cortex Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Basement Membrane Basal Lamina Extracellular Matrix Extracellular Vesicular Exosome Cell Periphery
	Molecular Function	Heparin Binding	Calcium Ion Binding Collagen Binding Laminin Binding Laminin-1 Binding Proteoglycan Binding
	Biological Process	Cell Adhesion Epidermis Development Extracellular Matrix Disassembly Extracellular Matrix Organization Hemidesmosome Assembly Cell Junction Assembly	Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Glomerular Basement Membrane Development Basement Membrane Organization
Pathways		Cell junction organization Type I hemidesmosome assembly Collagen formation Laminin interactions Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	Laminin interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Coronary heart disease ( 21347282) Systemic lupus erythematosus ( 21408207)	Cutaneous nevi ( 21478494)
Protein-Protein Interactions		6 interactors: BMP1 COL7A1 FBLN2 LAMB3 NID1 SLA2	21 interactors: APP COL13A1 COL1A1 COL4A1 FBLN1 FBLN2 FGA FGB HSPG2 ITGAV ITGB3 LACRT LAMA1 LAMC1 LAMC2 LGALS3BP PLAU PLXDC1 PRELP PTPRF SKIL
Entrez ID		3918	4811
HPRD ID		01031	00574
Ensembl ID		ENSG00000058085	ENSG00000116962
Uniprot IDs		Q13753	P14543
PDB IDs			1NDX
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Endodermal Cell Differentiation Endoderm Formation Cell Adhesion Endoderm Development Positive Regulation Of Cell-substrate Adhesion Formation Of Primary Germ Layer Gastrulation Regulation Of Cell-substrate Adhesion Epidermis Development Negative Regulation Of Calcium-mediated Signaling Hemidesmosome Assembly Positive Regulation Of Cell Adhesion Glomerular Basement Membrane Development Basement Membrane Organization Cartilage Condensation Tissue Development	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Cell Adhesion Regulation Of Body Fluid Levels Cell-substrate Adhesion Blood Coagulation Hemostasis Blood Vessel Development Vasculature Development Cell-matrix Adhesion Platelet Degranulation Locomotion Wound Healing Chemotaxis Platelet Activation Regulation Of Cell-substrate Adhesion Regulation Of Cell Adhesion Axon Guidance Blood Vessel Morphogenesis Response To Wounding Anatomical Structure Morphogenesis Movement Of Cell Or Subcellular Component Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Axonogenesis Platelet Aggregation Cardiovascular System Development Tissue Development Retinal Blood Vessel Morphogenesis Endochondral Ossification Axon Development Substrate Adhesion-dependent Cell Spreading Angiogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Receptor Biosynthetic Process Apolipoprotein A-I-mediated Signaling Pathway Response To External Stimulus Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell-substrate Junction Assembly Neuron Projection Morphogenesis Vesicle-mediated Transport Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Anatomical Structure Formation Involved In Morphogenesis Developmental Process Collagen Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Morphogenesis Involved In Differentiation Negative Regulation Of Lipoprotein Metabolic Process Multicellular Organismal Development
Tagcloud ?		accumulating adhesion alpha3beta1 alpha6beta4 anticancer attractive autocrine barrier basement biomarker countries crucial drive egfrs indicates influences inhibiting integrins lamina laminin laminins layers mechanical membranes migration morbidity network transformed tumorigenesis	accordance biogenesis bound brains clip details enriched immunoprecipitation intron linking messenger mirna mirnas neurexin neurodegeneration neurodevelopmental neurological nrxn1 pirnas processed reexamine represses rnas seq srnas systematically tar tardbp tdp
Tagcloud (Difference) ?		accumulating adhesion alpha3beta1 alpha6beta4 anticancer attractive autocrine barrier basement biomarker countries crucial drive egfrs indicates influences inhibiting integrins lamina laminin laminins layers mechanical membranes migration morbidity network transformed tumorigenesis	accordance biogenesis bound brains clip details enriched immunoprecipitation intron linking messenger mirna mirnas neurexin neurodegeneration neurodevelopmental neurological nrxn1 pirnas processed reexamine represses rnas seq srnas systematically tar tardbp tdp
Tagcloud (Intersection) ?