LAMC2 and LAMB3

Number of citations of the paper that reports this interaction (PMID 10964684)
1

Data Source:
HPRD (in vivo)

		LAMC2	LAMB3
Gene Name		laminin, gamma 2	laminin, beta 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Laminin-2 Complex Laminin-5 Complex Extracellular Space Cell Cortex Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Laminin-5 Complex
	Molecular Function	Heparin Binding	Structural Molecule Activity Protein Binding Protein Complex Binding
	Biological Process	Cell Adhesion Epidermis Development Extracellular Matrix Disassembly Extracellular Matrix Organization Hemidesmosome Assembly Cell Junction Assembly	Cell Adhesion Epidermis Development Extracellular Matrix Disassembly Extracellular Matrix Organization Hemidesmosome Assembly Cell Junction Assembly Endodermal Cell Differentiation Brown Fat Cell Differentiation
Pathways		Cell junction organization Type I hemidesmosome assembly Collagen formation Laminin interactions Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	Cell junction organization Type I hemidesmosome assembly Collagen formation Laminin interactions Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS		Coronary heart disease ( 21347282) Systemic lupus erythematosus ( 21408207)
Protein-Protein Interactions		6 interactors: BMP1 COL7A1 FBLN2 LAMB3 NID1 SLA2	5 interactors: BMP1 COL7A1 LAMA3 LAMC2 THBS1
Entrez ID		3918	3914
HPRD ID		01031	01032
Ensembl ID		ENSG00000058085	ENSG00000196878
Uniprot IDs		Q13753	Q13751
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Endodermal Cell Differentiation Endoderm Formation Cell Adhesion Endoderm Development Positive Regulation Of Cell-substrate Adhesion Formation Of Primary Germ Layer Gastrulation Regulation Of Cell-substrate Adhesion Epidermis Development Negative Regulation Of Calcium-mediated Signaling Hemidesmosome Assembly Positive Regulation Of Cell Adhesion Glomerular Basement Membrane Development Basement Membrane Organization Cartilage Condensation Tissue Development	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Tissue Development Hemidesmosome Assembly Epidermis Development Endodermal Cell Differentiation Cell Adhesion Cell-substrate Junction Assembly Endoderm Formation Endoderm Development Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Formation Of Primary Germ Layer Anatomical Structure Development Anatomical Structure Morphogenesis Engulfment Of Apoptotic Cell Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Gastrulation Cartilage Development Developmental Process Cell Junction Assembly Negative Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Anatomical Structure Formation Involved In Morphogenesis Epithelium Development Negative Regulation Of Antigen Processing And Presentation Connective Tissue Development Regulation Of CGMP-mediated Signaling Negative Regulation Of Endopeptidase Activity Skeletal System Morphogenesis Negative Regulation Of Peptidase Activity Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Plasminogen Activation Positive Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Fibrinolysis Negative Regulation Of Proteolysis Positive Regulation Of Fibroblast Migration Protein O-linked Fucosylation Positive Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Protein Processing Positive Regulation Of Macrophage Activation Regulation Of Endopeptidase Activity Cellular Response To Nitric Oxide Negative Regulation Of Hydrolase Activity Chronic Inflammatory Response Phagocytosis, Engulfment Regulation Of Fibrinolysis Regulation Of Protein Processing
Tagcloud ?		accumulating adhesion alpha3beta1 alpha6beta4 anticancer attractive autocrine barrier basement biomarker countries crucial drive egfrs indicates influences inhibiting integrins lamina laminin laminins layers mechanical membranes migration morbidity network transformed tumorigenesis	besides built c13orf18 ccl3 cish clustering comprising cytoreductive discriminators et fosb gadd45b granulocytes hrh4 id2 jak jak2v617f klf5 maff mutational pim1 signature socs2 socs3 stat supervised tagap thrombocythemia trib1
Tagcloud (Difference) ?		accumulating adhesion alpha3beta1 alpha6beta4 anticancer attractive autocrine barrier basement biomarker countries crucial drive egfrs indicates influences inhibiting integrins lamina laminin laminins layers mechanical membranes migration morbidity network transformed tumorigenesis	besides built c13orf18 ccl3 cish clustering comprising cytoreductive discriminators et fosb gadd45b granulocytes hrh4 id2 jak jak2v617f klf5 maff mutational pim1 signature socs2 socs3 stat supervised tagap thrombocythemia trib1
Tagcloud (Intersection) ?