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KRTAP10-3 and SPRY2
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
KRTAP10-3
SPRY2
Gene Name
keratin associated protein 10-3
sprouty homolog 2 (Drosophila)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Keratin Filament
Cytosol
Microtubule
Plasma Membrane
Microtubule Cytoskeleton
Ruffle Membrane
Molecular Function
Protein Binding
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Protein Serine/threonine Kinase Activator Activity
Biological Process
Establishment Of Mitotic Spindle Orientation
Epidermal Growth Factor Receptor Signaling Pathway
Sensory Perception Of Sound
Negative Regulation Of Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Negative Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Ras GTPase Activity
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Inner Ear Morphogenesis
Negative Regulation Of Apoptotic Process
Negative Regulation Of MAP Kinase Activity
Cell Fate Commitment
Negative Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Lung Growth
Bud Elongation Involved In Lung Branching
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways
Signaling by EGFR
EGFR downregulation
Signaling by FGFR in disease
Signaling by EGFR in Cancer
Signaling by Ligand-Responsive EGFR Variants in Cancer
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by EGFRvIII in Cancer
Spry regulation of FGF signaling
Signaling by FGFR
Negative regulation of FGFR signaling
Drugs
Diseases
GWAS
Adiposity (
21706003
)
Fasting insulin-related traits (interaction with BMI) (
22581228
)
Orofacial clefts (
20023658
22863734
)
Type 2 diabetes (
20862305
)
Protein-Protein Interactions
288 interactors:
ACY3
ADAMTSL3
ADAMTSL4
ADAMTSL5
AEN
AES
ALDH3B1
ALPI
ALPP
AP1M1
AQP1
AREG
AVPI1
B4GALT7
BAHD1
BCL6B
BMP7
BMS1P5
BUD31
BYSL
C10orf62
C16orf59
C19orf57
C19orf66
C22orf39
C9orf9
CARD9
CARHSP1
CARKD
CATIP
CATSPER1
CBX2
CCDC26
CCER1
CD164
CD300A
CD300LG
CDK5R1
CERK
CHIC2
CHRD
CHRNG
CLDN2
CLK3
CLK4
COL8A1
CREB5
CST2
CST9L
CTNNBIP1
CTRC
CXCL16
DAAM2
DDX43
DDX6
DERL2
DHRS1
DHX57
DMRT3
DNAL4
DOCK2
EFNA3
EGFL8
FAM124B
FAM161A
FAM27E3
FAM71E2
FAM74A4
FAM76B
FARS2
FBXL18
FBXW5
FOXB1
FZD9
GABARAPL1
GATA2
GEM
GFOD1
GIP
GLIDR
GLIPR2
GLP1R
GLRX3
GNE
GNMT
GOLGA8EP
GPRIN2
GSTP1
GTF3C5
HBG1
HBZ
HHEX
HIST3H2A
HOXA1
HPCAL1
HSBP1
HSD3B7
HSPD1
HYAL2
IGSF8
IL2RG
INPP5D
IQUB
IWS1
JOSD1
KAT5
KCNK1
KIAA0040
KIF9
KLHL38
KLK15
KLK8
KRT83
KRTAP10-1
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-1
KRTAP13-1
KRTAP26-1
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-7
KRTAP5-6
KRTAP5-9
KRTAP9-2
LCE1B
LCE2A
LCE3C
LCE3E
LIMS2
LINC00636
LINC01588
LMF2
LMNA
LUZP4
LYVE1
MAPKBP1
MEOX2
MOBP
MPP3
MRPL40
MXI1
NAA10
NAB2
NDUFAF3
NID2
NLK
NOTCH2NL
NPBWR2
NPDC1
NPPB
NUBP2
NUDCD3
NUFIP2
OLFM2
OPCML
OTX1
P2RY6
PCED1A
PCSK5
PDE9A
PDIA5
PGAP2
PGLS
PIGS
PIN1
PKD2
PLSCR1
POLL
PPARD
PRKAA2
PRKAB2
PRKAG1
PRPF31
PTGDS
PTGER3
PTPMT1
PTPRH
PVR
PVRL2
PVRL3
QPRT
R3HDM2
RAB7A
RAMP3
RHNO1
RNF175
RPS19BP1
RPS28
RPUSD3
RTN4RL1
SCNM1
SDC3
SDCBP
SELM
SERF2
SLC15A3
SLC23A1
SLC25A10
SLC25A48
SLC35A2
SLC43A2
SLC6A20
SMCO4
SMCP
SMOC1
SNAI1
SNHG11
SPATA3
SPATA8
SPG7
SPINK2
SPRY1
SPRY2
STK16
TBC1D23
TCEB3
THAP10
THAP7
TINAGL1
TMEM106C
TMEM8A
TNFRSF6B
TNIP3
TNK2
TNP2
TNS2
TRIM42
TRPV6
TTC23
TXNDC5
TYMSOS
TYRO3
UCP2
UNC45A
UTP23
VPS11
WFDC10B
WIF1
WT1
XCL1
YIPF3
ZBTB24
ZBTB9
ZFYVE21
ZFYVE26
ZMYND10
ZNF101
ZNF124
ZNF136
ZNF138
ZNF155
ZNF165
ZNF20
ZNF202
ZNF23
ZNF250
ZNF26
ZNF264
ZNF266
ZNF32
ZNF417
ZNF433
ZNF439
ZNF446
ZNF461
ZNF490
ZNF559
ZNF564
ZNF572
ZNF578
ZNF581
ZNF587
ZNF625
ZNF670
ZNF679
ZNF697
ZNF699
ZNF763
ZNF786
ZNF79
ZNF792
ZNRF2P1
ZSCAN21
ZSCAN26
90 interactors:
ADAMTSL4
AQP1
ATRIP
C19orf66
CATSPER1
CBL
CBLB
CBLC
CHRD
CREB5
CRIP2
CRMP1
CSTB
CTSB
DGCR6
DNM2
EIF4E2
FAIM
FAM219A
FBN1
FRS3
GNE
GP9
GPRIN2
GRAP2
GRB2
HEXIM2
HSD3B7
ITSN1
KDM1A
KIF1A
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP4-11
KRTAP4-12
KRTAP4-7
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-4
LASP1
LCE1B
LCE2D
LCE3C
LCE3E
LCE4A
LONRF1
MAPKBP1
MDFI
MEOX2
MID2
MKNK1
MLLT6
NCK2
NEDD4
NR1H2
NUBP1
OTX1
PACSIN3
PLSCR1
PRKAB2
PTGER3
PTPN11
RAF1
RTFDC1
RUNX1T1
SDHB
SEMA5B
SH3KBP1
SIAH2
SPRY1
STK16
TCAF1
TRAF2
TRIM51
TXNDC5
UBASH3A
UBASH3B
UBR1
USP20
VPS25
VPS36
ZBTB16
ZNF266
ZNF417
ZNF587
Entrez ID
386682
10253
HPRD ID
11189
03916
Ensembl ID
ENSG00000136158
Uniprot IDs
P60369
O43597
PDB IDs
3BUM
3OB1
Enriched GO Terms of Interacting Partners
?
Transcription, DNA-templated
RNA Biosynthetic Process
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Gene Expression
Cellular Nitrogen Compound Metabolic Process
Macromolecule Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Cellular Process
Cellular Process
Cellular Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Immune Response To Tumor Cell
Developmental Process
Susceptibility To T Cell Mediated Cytotoxicity
Negative Regulation Of MAP Kinase Activity
Pattern Specification Process
Transepithelial Transport
Negative Regulation Of Cell Proliferation
Fertilization
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Protein Serine/threonine Kinase Activity
Negative Regulation Of Glomerular Mesangial Cell Proliferation
Fusion Of Virus Membrane With Host Plasma Membrane
Negative Regulation Of Glomerulus Development
Positive Regulation Of Urine Volume
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Serine Phosphorylation Of STAT3 Protein
Negative Regulation Of Signal Transduction
Organ Development
Multicellular Organismal Development
Negative Regulation Of Transcription, DNA-templated
Branching Morphogenesis Of An Epithelial Tube
Negative Regulation Of MAPK Cascade
Metanephric Mesenchyme Development
Negative Regulation Of Signaling
Urogenital System Development
Keratinization
Regulation Of Cell Motility
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Signaling
Regulation Of Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of ERBB Signaling Pathway
Keratinization
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Regulation Of Signaling
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Protein Metabolic Process
Regulation Of Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Protein Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cellular Process
Keratinocyte Differentiation
Regulation Of Cell Activation
Negative Regulation Of Protein Metabolic Process
Fibroblast Growth Factor Receptor Signaling Pathway
Cell Death
System Development
Death
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Cell-cell Adhesion
Developmental Process
Multicellular Organismal Development
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Regulation Of T Cell Activation
Cellular Response To Organic Substance
Cell Differentiation
Anatomical Structure Development
Organ Development
Positive Regulation Of T Cell Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Protein Ubiquitination
Cellular Response To Growth Factor Stimulus
Regulation Of Protein Kinase Activity
Epidermal Cell Differentiation
Response To Growth Factor
Protein Modification By Small Protein Conjugation
Epithelium Development
Regulation Of Apoptotic Process
Regulation Of Cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of Kinase Activity
Regulation Of Immune System Process
Negative Regulation Of Cellular Metabolic Process
Tagcloud
?
beyond
carcinogenesis
carcinogenic
cdh1
chfr
continue
detailed
endometrial
explained
familial
generations
germ
grow
hmlh1
hypermethylation
imbalance
inherited
involve
micrornas
mir
mismatch
mmr
oncogenes
pten
rassf1a
rsk4
unopposed
worldwide
younger
Tagcloud (Difference)
?
beyond
carcinogenesis
carcinogenic
cdh1
chfr
continue
detailed
endometrial
explained
familial
generations
germ
grow
hmlh1
hypermethylation
imbalance
inherited
involve
micrornas
mir
mismatch
mmr
oncogenes
pten
rassf1a
rsk4
unopposed
worldwide
younger
Tagcloud (Intersection)
?