KRTAP10-3 and UCP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KRTAP10-3	UCP2
Description		keratin associated protein 10-3	uncoupling protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane
	Molecular Function		Protein Binding Secondary Active Sulfate Transmembrane Transporter Activity Proton Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Oxaloacetate Transmembrane Transporter Activity Malate Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity Antiporter Activity Oxidative Phosphorylation Uncoupler Activity GDP Binding Protein Homodimerization Activity Phosphate Ion Uniporter Activity
	Biological Process		Mitochondrial Fission Response To Superoxide Response To Hypoxia Glycolytic Process Glutamine Metabolic Process Mitochondrial Transport Response To Cold Response To Glucose Inorganic Anion Transport C4-dicarboxylate Transport Long-chain Fatty Acid Transport Macrophage Differentiation Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Cellular Response To Amino Acid Starvation Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Potential Transmembrane Transport Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Fatty Acid L-aspartate Transmembrane Transport Cellular Response To Lead Ion Cellular Response To Glucose Stimulus Malate Transmembrane Transport Response To Dexamethasone Reactive Oxygen Species Metabolic Process Liver Regeneration Negative Regulation Of Calcium Import Into The Mitochondrion Positive Regulation Of Cold-induced Thermogenesis Oxaloacetate(2-) Transmembrane Transport Sulfate Transmembrane Transport Chloride Transmembrane Transport Proton Transmembrane Transport Mitochondrial Transmembrane Transport Adaptive Thermogenesis
Pathways		Keratinization	The fatty acid cycling model
Drugs
Diseases
GWAS			Mean platelet volume ( 32888494)
Interacting Genes		293 interacting genes: ACY3 ADAMTSL3 ADAMTSL4 ADAMTSL5 AEN ALDH3B1 ALPI ALPP AMMECR1 AP1M1 AQP1 AREG AVPI1 AXIN1 B4GALT7 BAHD1 BCL6B BMP7 BMS1P1 BRME1 BUD31 BYSL C10orf62 C22orf39 CARD9 CARHSP1 CATIP CATSPER1 CBX2 CCDC26 CCER1 CD164 CD300A CD300LG CDK5R1 CERK CHIC2 CHRD CHRNG CLDN2 CLK3 CLK4 COL8A1 CREB5 CST2 CST9L CTNNBIP1 CTRC CXCL16 DAAM2 DDX43 DDX6 DERL2 DHRS1 DHX57 DMRT3 DNAL4 DOCK2 EFNA3 EGFL8 ELOA FAM124B FAM161A FAM27E3 FAM74A4 FAM76B FARS2 FBXL18 FBXW5 FOXB1 FZD9 GABARAPL1 GARIN5B GATA2 GEM GFOD1 GIP GLIDR GLIPR2 GLP1R GLRX3 GNE GNMT GOLGA8EP GPRIN2 GSTP1 GTF3C5 H2AC25 HBG1 HBZ HHEX HNRNPLL HOXA1 HPCAL1 HSBP1 HSD3B7 HSPD1 HYAL2 IGSF8 IL2RG INPP5D IQUB IWS1 JOSD1 KAT5 KCNK1 KIAA0040 KIF9 KLHL38 KLK15 KLK8 KRT83 KRTAP10-1 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP13-1 KRTAP26-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 LCE1B LCE2A LCE3C LCE3E LIMS2 LINC00636 LINC01588 LMF2 LMNA LUZP4 LYVE1 MAPKBP1 MEOX2 MOBP MPP3 MRPL40 MXI1 NAA10 NAB2 NAXD NDUFAF3 NECTIN2 NECTIN3 NID2 NLK NOTCH2NLA NPBWR2 NPDC1 NPPB NUBP2 NUDCD3 NUFIP2 OLFM2 OPCML OTX1 P2RY6 PCED1A PCSK5 PDE9A PDIA5 PGAP2 PGAP6 PGLS PIGS PIN1 PKD2 PLSCR1 POLL PPARD PRKAA2 PRKAB2 PRKAG1 PRPF31 PTGDS PTGER3 PTPMT1 PTPRH PVR QPRT R3HDM2 RAB7A RAMP3 RHNO1 RNF175 RPS19BP1 RPS28 RPUSD3 RTN4RL1 SCNM1 SDC3 SDCBP SELENOM SERF2 SHFL SLC15A3 SLC23A1 SLC25A10 SLC25A48 SLC35A2 SLC43A2 SLC6A20 SMCO4 SMCP SMOC1 SNAI1 SNHG11 SPACA9 SPATA3 SPATA8 SPG7 SPINK2 SPRY1 SPRY2 STK16 TBC1D23 TEAD4 TEDC2 THAP10 THAP7 TINAGL1 TLE5 TMEM106C TNFRSF6B TNIP3 TNK2 TNP2 TNS2 TRIM42 TRPV6 TTC23 TXNDC5 TYMSOS TYRO3 UCP2 UNC45A UTP23 VPS11 WFDC10B WIF1 WT1 XCL1 YIPF3 ZBTB24 ZBTB9 ZFYVE21 ZFYVE26 ZMYND10 ZNF101 ZNF124 ZNF136 ZNF138 ZNF155 ZNF165 ZNF20 ZNF202 ZNF23 ZNF250 ZNF26 ZNF264 ZNF266 ZNF32 ZNF417 ZNF433 ZNF439 ZNF446 ZNF461 ZNF490 ZNF559 ZNF564 ZNF572 ZNF578 ZNF581 ZNF587 ZNF625 ZNF670 ZNF679 ZNF688 ZNF697 ZNF699 ZNF763 ZNF786 ZNF79 ZNF792 ZNRF2P1 ZSCAN21 ZSCAN26	6 interacting genes: KRTAP10-3 KRTAP10-7 YWHAB YWHAG YWHAQ YWHAZ
Entrez ID		386682	7351
HPRD ID		11189	03410
Ensembl ID		ENSG00000212935	ENSG00000175567
Uniprot IDs		P60369	P55851
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Keratin Filament Intermediate Filament RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Zinc Ion Binding Regulation Of Transcription By RNA Polymerase II DNA Binding Hair Cycle AMP-activated Protein Kinase Activity	Protein Domain Specific Binding Protein Targeting Protein Sequestering Activity Phosphoserine Residue Binding Identical Protein Binding Focal Adhesion Negative Regulation Of Protein Localization To Nucleus Cellular Response To Glucose Starvation Negative Regulation Of TORC1 Signaling TORC1 Signaling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Melanosome Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling TOR Signaling Keratin Filament Synaptic Target Recognition Establishment Of Protein Localization Vascular Endothelial Growth Factor Receptor 1 Binding Negative Regulation Of Macromolecule Metabolic Process Protein Kinase C Inhibitor Activity Transmembrane Transporter Binding Vascular Endothelial Growth Factor Receptor Binding Negative Regulation Of Metabolic Process Regulation Of Protein Localization To Nucleus Regulation Of TOR Signaling Intermediate Filament Golgi Reassembly Vesicle Positive Regulation Of Vascular Wound Healing Positive Regulation Of Mast Cell Chemotaxis Cellular Response To Starvation Regulation Of Mast Cell Chemotaxis Intracellular Protein Localization Negative Regulation Of Protein Localization Negative Regulation Of Immune Response Response To Starvation Establishment Of Golgi Localization Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Phosphorylation-dependent Protein Binding Regulation Of Protein Localization Cellular Response To Nutrient Levels Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Cytosol Regulation Of ERK1 And ERK2 Cascade Regulation Of Vascular Wound Healing Extracellular Exosome Vacuolar Membrane Negative Regulation Of Immune Response To Tumor Cell
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