RECQL and KPNA4

Number of citations of the paper that reports this interaction (PubMedID 9168958)
0

Data Source:
BioGRID (pull down)
HPRD (two hybrid, in vitro)

		RECQL	KPNA4
Description		RecQ like helicase	karyopherin subunit alpha 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Membrane	Male Germ Cell Nucleus Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Nuclear Membrane NLS-dependent Protein Nuclear Import Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Double-stranded DNA Helicase Activity 3'-5' DNA Helicase Activity Metal Ion Binding DNA/DNA Annealing Activity	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair DNA Recombination Replication Fork Processing	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Gene Expression Dopamine Secretion Protein Transport Positive Regulation Of Hippo Signaling Response To Hydrogen Peroxide
Pathways			ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 32279069) Bipolar disorder ( 31043756) Malaria ( 31844061) Myeloproliferative neoplasms ( 33057200) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)
Interacting Genes		8 interacting genes: CEBPA E2F4 KPNA2 KPNA4 LINC00632 NEIL3 RPA1 UBC	49 interacting genes: ADNP AFF2 APP CDKN1B CFAP298 CSE1L CSNK2A1 CTDSPL2 CUL4B DMTF1 DYRK1A EXO1 FAM50B GTF2IRD1 HIF1A HJURP HNRNPC HSD3B7 KAT5 KDR MAT2B MEF2C MORC3 MRTFB MTA1 NCBP3 NCOR2 NFE2L2 NKX2-5 NRIP1 NTRK3 OGT PLAA PLEKHG4B RAC1 RANBP3 RECQL RNF38 RYBP SCAND3 SPRTN SQSTM1 TGM2 TPX2 WT1 ZFTRAF1 ZMIZ2 ZNF532 ZRANB3
Entrez ID		5965	3840
HPRD ID		02762	04275
Ensembl ID		ENSG00000004700	ENSG00000186432
Uniprot IDs		P46063	O00629
PDB IDs		2V1X 2WWY 4U7D 6JTZ 8YRS	4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB 6WX8 7JJL 7LF4 7LFC 7RFY 7RG5 8FUB 8FZM 8HKW
Enriched GO Terms of Interacting Partners?		NLS-dependent Protein Nuclear Import Complex Nucleoplasm NLS-bearing Protein Import Into Nucleus Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity Base-excision Repair RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Hippo Signaling Male Germ Cell Nucleus Ventral Spinal Cord Interneuron Fate Determination Type B Pancreatic Cell Fate Commitment MCM Complex Binding Damaged DNA Binding Response To Vitamin B2 C/EBP Complex Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Cell Development Chromatin Binding CHOP-C/EBP Complex Histone Deacetylase Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific White Fat Cell Proliferation RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Epithelial Cell Development Import Into Nucleus Protein Import Into Nucleus Viral Penetration Into Host Nucleus Spinal Cord Oligodendrocyte Cell Differentiation Oligodendrocyte Cell Fate Specification Spinal Cord Oligodendrocyte Cell Fate Specification Single-stranded Telomeric DNA Binding Single-stranded DNA Binding Depurination	Nucleus Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Rhythmic Process Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Positive Regulation Of Developmental Process Chromatin Organization Regulation Of Developmental Growth Apoptotic Process Regulation Of MiRNA Metabolic Process Regulation Of Cellular Component Organization Regulation Of Growth Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Chromatin Regulation Of Synapse Assembly Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Programmed Cell Death Cell Death Regulation Of Cell Junction Assembly DNA Binding DNA Repair Epithelial Tube Morphogenesis Regulation Of Synapse Organization Positive Regulation Of Catabolic Process
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