KPNA2 and CSE1L

Number of citations of the paper that reports this interaction (PMID 9323134)
153

Data Source:
BioGRID (pull down)

		KPNA2	CSE1L
Gene Name		karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	CSE1 chromosome segregation 1-like (yeast)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane	Nucleus Nucleoplasm Cytoplasm Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Protein Transporter Activity Histone Deacetylase Binding Poly(A) RNA Binding	Protein Binding Importin-alpha Export Receptor Activity Ran GTPase Binding
	Biological Process	Regulation Of DNA Recombination DNA Metabolic Process NLS-bearing Protein Import Into Nucleus Viral Process Cytokine-mediated Signaling Pathway	Protein Export From Nucleus Apoptotic Process Cell Proliferation
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS
Protein-Protein Interactions		104 interactors: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A BRCA1 BTBD2 CASP2 CCDC107 CDA CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSE1L CSNK1A1 CUL4B DCTN2 DDIT3 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 H1F0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MVP MYC NECAB2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RAN RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SART3 SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131	15 interactors: CDH1 HNRNPL KPNA1 KPNA2 KPNA4 KPNA6 KPNB1 MAPK6 PPP5C RAN RPL22 STAT1 TMEM62 YWHAG YWHAQ
Entrez ID		3838	1434
HPRD ID		02818	03217
Ensembl ID		ENSG00000182481	ENSG00000124207
Uniprot IDs		P52292 Q7Z726	P55060
PDB IDs		1EFX 1QGK 1QGR 3FEX 3FEY 4E4V
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Cellular Process RNA Biosynthetic Process Gene Expression Response To Stimulus Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Cell Death Death Apoptotic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Programmed Cell Death Viral Process Organelle Organization Regulation Of Nucleic Acid-templated Transcription Signal Transduction Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Developmental Process Regulation Of Transcription, DNA-templated Signaling Positive Regulation Of Transcription, DNA-templated Protein Localization To Nucleus Macromolecule Biosynthetic Process Cellular Localization Cell Cycle Negative Regulation Of Biosynthetic Process Cell Communication Negative Regulation Of Nucleic Acid-templated Transcription Cellular Process Negative Regulation Of RNA Biosynthetic Process Cell Cycle Process Response To Stress Positive Regulation Of Gene Expression Nucleocytoplasmic Transport Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Nuclear Transport Positive Regulation Of Macromolecule Biosynthetic Process Multicellular Organismal Development	Protein Targeting NLS-bearing Protein Import Into Nucleus Protein Import Into Nucleus Nuclear Import Protein Import Protein Localization To Nucleus Intracellular Protein Transport Cellular Protein Localization Establishment Of Protein Localization To Organelle Establishment Of Protein Localization Nucleocytoplasmic Transport Nuclear Transport Protein Localization To Organelle Protein Localization Protein Transport Intracellular Transport Cytoplasmic Transport Cellular Localization Establishment Of Localization In Cell Viral Process Intracellular Transport Of Virus Viral Life Cycle Cytokine-mediated Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Intracellular Transport Apoptotic Process Execution Phase Of Apoptosis Programmed Cell Death Cellular Response To Cytokine Stimulus Cell Death Death DNA Metabolic Process Response To Organic Substance Response To Cytokine Cellular Response To Organic Substance Apoptotic DNA Fragmentation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Intracellular Transport Signal Transduction Cellular Response To Stimulus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Nuclear Changes Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Signaling Cell Communication Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Establishment Of Protein Localization Transport
Tagcloud ?		aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus	accord activators aspartyl biomolecular cathepsin cd138 curve cyclooxygenase distinctly done egr1 erbb2 h1 immunohistochemical lin28 met minus nasopharyngeal nm23 p63 prognostic segregation separated stainings stat5 stratify syndecan transducers usual
Tagcloud (Difference) ?		aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus	accord activators aspartyl biomolecular cathepsin cd138 curve cyclooxygenase distinctly done egr1 erbb2 h1 immunohistochemical lin28 met minus nasopharyngeal nm23 p63 prognostic segregation separated stainings stat5 stratify syndecan transducers usual
Tagcloud (Intersection) ?