NUP50 and RAN

Number of citations of the paper that reports this interaction (PubMedID 12176322)
0

Data Source:
HPRD (in vivo, in vitro)

		NUP50	RAN
Description		nucleoporin 50	RAN, member RAS oncogene family
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Membrane Nuclear Membrane	Chromatin Male Germ Cell Nucleus Manchette Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Nucleolus Cytoplasm Centriole Cytosol Membrane Midbody Protein-containing Complex Sperm Flagellum Melanosome RNA Nuclear Export Complex Recycling Endosome Extracellular Exosome Flemming Body
	Molecular Function	Protein Binding	Nucleotide Binding Magnesium Ion Binding Chromatin Binding RNA Binding GTPase Activity G Protein Activity Nuclear Export Signal Receptor Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Protein-containing Complex Binding Cadherin Binding Dynein Intermediate Chain Binding Metal Ion Binding Protein Heterodimerization Activity Importin-alpha Family Protein Binding Pre-miRNA Binding
	Biological Process	Neural Tube Formation Protein Import Into Nucleus Nucleocytoplasmic Transport Protein Transport MRNA Transport	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Glycolytic Process DNA Metabolic Process Protein Import Into Nucleus Protein Export From Nucleus Nucleocytoplasmic Transport Mitotic Spindle Organization Spermatid Development Intracellular Protein Localization Protein Transport Viral Process Hippocampus Development Actin Cytoskeleton Organization Protein-containing Complex Localization Pre-miRNA Export From Nucleus Positive Regulation Of Protein Import Into Nucleus GTP Metabolic Process Cell Division SnRNA Import Into Nucleus Cellular Response To Mineralocorticoid Stimulus Protein Localization To Nucleolus
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses	Rev-mediated nuclear export of HIV RNA Regulation of cholesterol biosynthesis by SREBP (SREBF) NEP/NS2 Interacts with the Cellular Export Machinery Nuclear import of Rev protein MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs tRNA processing in the nucleus Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation
Drugs			Guanosine-5'-Diphosphate
Diseases
GWAS		Mean corpuscular volume ( 32888494)
Interacting Genes		12 interacting genes: APP CDKN1B CEBPA CEBPB IPO13 KEAP1 KPNA2 KPNB1 OGT RAN SRPK2 XPO1	62 interacting genes: ABL1 ADRB2 AR ASAP2 BCAR1 BIRC5 BMPR1B CEP126 CSE1L DUX4 EP300 FNDC3B FOXP1 GADD45G GIT1 IPO11 IPO13 IPO4 IPO5 IPO7 IPO8 IPO9 KPNB1 MBP MSL1 NEK9 NR3C1 NSMF NUP153 NUP50 NUTF2 NXF1 NXT1 PAK4 PARP10 PTMA RANBP1 RANBP10 RANBP2 RANBP3 RANBP9 RANGAP1 RANGRF RCC1 RGPD5 RPL7 SMAD1 SMAD2 SMARCB1 SMURF2 SPAG8 SSRP1 SUMO2 TGFBR1 TNPO1 VRK2 VRK3 XPO1 XPO4 XPO5 XPO7 XPOT
Entrez ID		10762	5901
HPRD ID		05226	03109
Ensembl ID		ENSG00000093000	ENSG00000132341
Uniprot IDs		B4E2D3 Q9UKX7	B4DV51 P62826
PDB IDs		2EC1 3TJ3 7MO0	1I2M 1IBR 1K5D 1K5G 1QBK 1RRP 2MMC 2MMG 2N1B 3CH5 3EA5 3GJ0 3GJ3 3GJ4 3GJ5 3GJ6 3GJ7 3GJ8 3GJX 3NBY 3NBZ 3NC0 3NC1 3ZJY 4C0Q 4GMX 4GPT 4HAT 4HAU 4HAV 4HAW 4HAX 4HAY 4HAZ 4HB0 4HB2 4HB3 4HB4 4OL0 4WVF 5CIQ 5CIT 5CIW 5CJ2 5CLL 5CLQ 5DH9 5DHA 5DHF 5DI9 5DIF 5DIS 5DLQ 5FYQ 5JLJ 5UWH 5UWI 5UWJ 5UWO 5UWP 5UWQ 5UWR 5UWS 5UWT 5UWU 5UWW 5YRO 5YST 5YSU 5YTB 5ZPU 6A38 6A3A 6A3B 6A3C 6A3E 6CIT 6KFT 6LQ9 6M60 6M6X 6Q82 6Q84 6TVO 6X2M 6X2O 6X2P 6X2R 6X2S 6X2U 6X2V 6X2W 6X2X 6X2Y 6XJP 6XJR 6XJS 6XJT 6XJU 7B51 7CND 7DBG 7L5E 7MNP 7MNQ 7MNR 7MNS 7MNT 7MNU 7MNV 7MNW 7MNX 7MNY 7MNZ 7MO0 7MO1 7MO2 7MO3 7MO4 7MO5 7YPZ 8HQ3 8HQ4 8HQ5 8HQ6 8HUF 8HUG 8ITV 8UX1 9B62
Enriched GO Terms of Interacting Partners?		Nuclear Transport Nucleocytoplasmic Transport Regulation Of Protein Catabolic Process Protein Localization To Nucleus Protein-containing Complex C/EBP Complex CHOP-C/EBP Complex Import Into Nucleus Protein Import Into Nucleus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Organelle RNA Import Into Nucleus Regulation Of Proteolysis Regulation Of RNA Metabolic Process Intracellular Transport Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleus Ribosomal Large Subunit Export From Nucleus Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Ribosomal Small Subunit Export From Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of RNA Metabolic Process Protein Domain Specific Binding Nucleoplasm Importin-alpha Family Protein Binding NLS-dependent Protein Nuclear Import Complex Intracellular Protein Transport Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Localization Establishment Of Localization In Cell Ribosomal Subunit Export From Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin DNA Binding Nuclear Export Signal Receptor Activity Cellular Response To Lithium Ion Notch Signaling Pathway Positive Regulation Of Metabolic Process Intracellular Signal Transduction Response To Lithium Ion Establishment Of Protein Localization To Organelle Protein Heterodimerization Activity Memory Positive Regulation Of Gene Expression	Small GTPase Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Pore Protein Import Into Nucleus Import Into Nucleus Intracellular Protein Transport Protein Localization To Nucleus Nucleus Nuclear Export Nuclear Envelope Establishment Of Localization In Cell Intracellular Transport Protein Transport Nucleoplasm Cellular Localization Protein Export From Nucleus Nuclear Import Signal Receptor Activity Protein Localization To Organelle Establishment Of Protein Localization To Organelle Establishment Of Protein Localization Intracellular Protein Localization RNA Transport Cytoplasm Nuclear Export Signal Receptor Activity Nuclear Membrane Nucleobase-containing Compound Transport Nuclear Localization Sequence Binding Cytosol Ribosomal Protein Import Into Nucleus Regulation Of Nucleocytoplasmic Transport MRNA Transport RNA Export From Nucleus Protein-containing Complex SMAD Binding NLS-bearing Protein Import Into Nucleus Protein Binding Nuclear Inclusion Body Homomeric SMAD Protein Complex Cytoplasmic Periphery Of The Nuclear Pore Complex Response To Growth Factor Mitotic Spindle Organization I-SMAD Binding Regulation Of Intracellular Transport Cellular Response To Growth Factor Stimulus Negative Regulation Of RNA Export From Nucleus SUMO Ligase Complex Nuclear Pore Cytoplasmic Filaments Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Cell Cycle
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