AP3S2 and AP3D1

Number of citations: 0 (PubMedID 15469849)
Data Source: BioGRID (two hybrid, pull down, affinity chromatography technology), HPRD (two hybrid)

		AP3S2	AP3D1
Name		adaptor related protein complex 3 subunit sigma 2	adaptor related protein complex 3 subunit delta 1
Structure		No pdb structure
GO Annotations	Cellular Component	Early Endosome Golgi Apparatus Synaptic Vesicle Membrane Membrane Coat AP-3 Adaptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Axon Cytoplasm	Golgi Membrane Cytoplasm Lysosomal Membrane Early Endosome Golgi Apparatus Endosome Membrane Membrane Membrane Coat AP-3 Adaptor Complex Axon Terminal Bouton Presynapse Postsynapse Presynaptic Endosome Glutamatergic Synapse Axon Cytoplasm
	Molecular Function	None	Protein Binding
	Biological Process	Intracellular Protein Transport Golgi To Vacuole Transport Anterograde Axonal Transport Protein Transport Synaptic Vesicle Coating Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Synaptic Vesicle Recycling Anterograde Synaptic Vesicle Transport Platelet Dense Granule Organization Melanosome Assembly	Protein Targeting Protein Targeting To Vacuole Intracellular Protein Transport Golgi To Vacuole Transport Lysosomal Transport Anterograde Axonal Transport Protein Transport Vesicle Organization Synaptic Vesicle Budding From Endosome Synaptic Vesicle Coating Vesicle-mediated Transport Antigen Processing And Presentation Melanosome Organization Protein Localization To Organelle Endosome To Melanosome Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Synaptic Vesicle Recycling Positive Regulation Of Transcription By RNA Polymerase II Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Anterograde Synaptic Vesicle Transport Synaptic Vesicle Membrane Organization Positive Regulation Of NK T Cell Differentiation Platelet Dense Granule Organization Protein Localization To Membrane Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Vesicle-mediated Transport In Synapse Zinc Ion Import Into Lysosome Melanosome Assembly
GWAS		Type 2 diabetes ( 21874001 23945395 24509480 28869590 29358691 30054458 30297969 30718926 32499647 ) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408 )	Height ( 28552196 31562340 ) Hematocrit ( 27863252 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin concentration ( 27863252 ) Hip circumference adjusted for BMI ( 34021172 ) Monocyte count ( 32888494 ) Myocardial infarction ( 24916648 ) Pulse pressure ( 30578418 ) Red blood cell count ( 27863252 32888494 ) Systolic blood pressure ( 30578418 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		7 interacting genes: AP3B1 AP3D1 AP3S1 ARF1 ARF6 E2F4 SCARB2	13 interacting genes: AP3S1 AP3S2 ARF1 ARF6 CCN2 CDC42 DUX4 FILNC1 GSK3A RUFY1 SLC30A3 VAMP7 VPS41
Entrez ID		10239	8943
HPRD ID		03880	06260
Ensembl ID		ENSG00000157823	ENSG00000065000
Uniprot IDs		P59780	A0A8V8TQW4 O14617
PDB IDs		Not available	4AFI 9C58 9C59 9C5B 9C5C
GO Terms Enriched among Interactors		Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Intracellular Protein Transport AP-3 Adaptor Complex Anterograde Synaptic Vesicle Transport Melanosome Assembly Platelet Dense Granule Organization Membrane Coat Vesicle Cargo Loading Vacuolar Transport Synaptic Vesicle Transport Melanosome Organization Pigment Granule Organization Protein Transport Vesicle-mediated Transport Vesicle Transport Along Microtubule Anterograde Axonal Transport Intracellular Transport Protein Targeting To Vacuole Positive Regulation Of NK T Cell Differentiation Establishment Of Protein Localization Vesicle Cytoskeletal Trafficking Protein Localization To Lysosome Synaptic Vesicle Coating Axon Cytoplasm Establishment Of Protein Localization To Vacuole Axonal Transport Secretory Granule Organization Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Regulation Of NK T Cell Differentiation Cellular Localization Establishment Of Localization In Cell Axo-dendritic Transport Early Endosome Organelle Transport Along Microtubule Protein Localization To Vacuole Intracellular Protein Localization Establishment Of Vesicle Localization Vesicle Localization Lysosomal Transport Synaptic Vesicle Recycling Organelle Localization Golgi To Vacuole Transport Localization Within Membrane Transport Along Microtubule Golgi Apparatus Cytoskeleton-dependent Intracellular Transport Protein Targeting Protein Localization To Organelle Protein Localization To Cell Surface Protein Targeting To Lysosome	Intracellular Transport AP-3 Adaptor Complex Vacuolar Transport Cellular Localization Establishment Of Localization In Cell Vesicle-mediated Transport Golgi Apparatus Golgi Vesicle Transport Vesicle Organization Membrane Organization Protein Transport Membrane Invagination Synaptic Vesicle Coating Intracellular Protein Localization Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Establishment Of Protein Localization Thioesterase Binding Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Organization Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Organelle Transport Along Microtubule Vesicle Fusion Regulation Of Transport Synaptic Vesicle Recycling Organelle Membrane Fusion Endosomal Vesicle Fusion Regulation Of Endocytosis Anterograde Synaptic Vesicle Transport Early Endosome Melanosome Assembly Golgi To Vacuole Transport Neuron Projection Regulation Of Actin Cytoskeleton Organization Lysosomal Transport Organelle Fusion Regulation Of Actin Filament-based Process Organelle Organization Platelet Dense Granule Organization Regulation Of Supramolecular Fiber Organization Intracellular Membrane-bounded Organelle Endosome Late Endosome Membrane Membrane Fusion Establishment Of Epithelial Cell Polarity Membrane Coat Phagocytosis, Engulfment Positive Regulation Of Transport Vesicle Cargo Loading Dendritic Spine Organization